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CHD2 (chromodomain helicase DNA binding protein 2)

Identity

Alias_symbol (synonym)FLJ38614
DKFZp547I1315
DKFZp781D1727
DKFZp686E01200
Other aliasEEOC
HGNC (Hugo) CHD2
LocusID (NCBI) 1106
Atlas_Id 43209
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 92900321 and ends at 92949233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / CHD2 (15q26.1)AKAP13 (15q25.3) / CHD2 (15q26.1)CHD2 (15q26.1) / AGBL1 (15q25.3)
CHD2 (15q26.1) / CHD2 (15q26.1)CHD2 (15q26.1) / HOMER2 (15q25.2)CHD2 (15q26.1) / OTUD5 (Xp11.23)
CHD2 (15q26.1) / POLI (18q21.2)CHD2 (15q26.1) / STARD9 (15q15.2)CHD2 (15q26.1) / TMCO3 (13q34)
CHD2 (15q26.1) / TPI1 (12p13.31)KIF13B (8p12) / CHD2 (15q26.1)LUC7L2 (7q34) / CHD2 (15q26.1)
RNF11 (1p32.3) / CHD2 (15q26.1)AKAP13 15q25.3 / CHD2 15q26.1CHD2 15q26.1 / HOMER2 15q25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHD2   1917
Cards
Entrez_Gene (NCBI)CHD2  1106  chromodomain helicase DNA binding protein 2
AliasesEEOC
GeneCards (Weizmann)CHD2
Ensembl hg19 (Hinxton)ENSG00000173575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173575 [Gene_View]  chr15:92900321-92949233 [Contig_View]  CHD2 [Vega]
ICGC DataPortalENSG00000173575
TCGA cBioPortalCHD2
AceView (NCBI)CHD2
Genatlas (Paris)CHD2
WikiGenes1106
SOURCE (Princeton)CHD2
Genetics Home Reference (NIH)CHD2
Genomic and cartography
GoldenPath hg38 (UCSC)CHD2  -     chr15:92900321-92949233 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHD2  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblCHD2 - 15q26.1 [CytoView hg19]  CHD2 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBICHD2 [Mapview hg19]  CHD2 [Mapview hg38]
OMIM602119   615369   
Gene and transcription
Genbank (Entrez)AA907775 AF006514 AK095933 AK292850 AK295909
RefSeq transcript (Entrez)NM_001042572 NM_001271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHD2
Cluster EST : UnigeneHs.220864 [ NCBI ]
CGAP (NCI)Hs.220864
Alternative Splicing GalleryENSG00000173575
Gene ExpressionCHD2 [ NCBI-GEO ]   CHD2 [ EBI - ARRAY_EXPRESS ]   CHD2 [ SEEK ]   CHD2 [ MEM ]
Gene Expression Viewer (FireBrowse)CHD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1106
GTEX Portal (Tissue expression)CHD2
Human Protein AtlasENSG00000173575-CHD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14647   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14647  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14647
Splice isoforms : SwissVarO14647
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusO14647
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)CHD2    Chromo/chromo_shadow_dom    Chromo_domain    Chromodomain-like    Chromodomain_CS    DUF4208    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    SNF2_N   
Domain families : Pfam (Sanger)Chromo (PF00385)    DUF4208 (PF13907)    Helicase_C (PF00271)    SNF2_N (PF00176)   
Domain families : Pfam (NCBI)pfam00385    pfam13907    pfam00271    pfam00176   
Domain families : Smart (EMBL)CHROMO (SM00298)  DEXDc (SM00487)  DUF4208 (SM01176)  HELICc (SM00490)  
Conserved Domain (NCBI)CHD2
DMDM Disease mutations1106
Blocks (Seattle)CHD2
SuperfamilyO14647
Human Protein Atlas [tissue]ENSG00000173575-CHD2 [tissue]
Peptide AtlasO14647
HPRD03669
IPIIPI00815893   IPI00023109   IPI00942840   IPI01024820   IPI01025343   IPI01012601   
Protein Interaction databases
DIP (DOE-UCLA)O14647
IntAct (EBI)O14647
FunCoupENSG00000173575
BioGRIDCHD2
STRING (EMBL)CHD2
ZODIACCHD2
Ontologies - Pathways
QuickGOO14647
Ontology : AmiGOcore promoter sequence-specific DNA binding  DNA binding  RNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  muscle organ development  covalent chromatin modification  DNA duplex unwinding  histone binding  intracellular membrane-bounded organelle  hematopoietic stem cell differentiation  extracellular exosome  
Ontology : EGO-EBIcore promoter sequence-specific DNA binding  DNA binding  RNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  muscle organ development  covalent chromatin modification  DNA duplex unwinding  histone binding  intracellular membrane-bounded organelle  hematopoietic stem cell differentiation  extracellular exosome  
NDEx NetworkCHD2
Atlas of Cancer Signalling NetworkCHD2
Wikipedia pathwaysCHD2
Orthology - Evolution
OrthoDB1106
GeneTree (enSembl)ENSG00000173575
Phylogenetic Trees/Animal Genes : TreeFamCHD2
HOVERGENO14647
HOGENOMO14647
Homologs : HomoloGeneCHD2
Homology/Alignments : Family Browser (UCSC)CHD2
Gene fusions - Rearrangements
Fusion : MitelmanAKAP13/CHD2 [15q25.3/15q26.1]  [t(15;15)(q25;q26)]  
Fusion : MitelmanCHD2/HOMER2 [15q26.1/15q25.2]  [t(15;15)(q25;q26)]  
Fusion: TCGA_MDACCAKAP13 15q25.3 CHD2 15q26.1 LUSC
Fusion: TCGA_MDACCCHD2 15q26.1 HOMER2 15q25.2 BRCA
Tumor Fusion PortalCHD2
Fusion Cancer (Beijing)AD_1 [CHD2]  -  15q26.1 [FUSC002703]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHD2
dbVarCHD2
ClinVarCHD2
1000_GenomesCHD2 
Exome Variant ServerCHD2
ExAC (Exome Aggregation Consortium)ENSG00000173575
GNOMAD BrowserENSG00000173575
Genetic variants : HAPMAP1106
Genomic Variants (DGV)CHD2 [DGVbeta]
DECIPHERCHD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHD2 
Mutations
ICGC Data PortalCHD2 
TCGA Data PortalCHD2 
Broad Tumor PortalCHD2
OASIS PortalCHD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHD2
DgiDB (Drug Gene Interaction Database)CHD2
DoCM (Curated mutations)CHD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHD2 (select a term)
intoGenCHD2
Cancer3DCHD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602119    615369   
Orphanet885    891   
DisGeNETCHD2
MedgenCHD2
Genetic Testing Registry CHD2
NextProtO14647 [Medical]
TSGene1106
GENETestsCHD2
Target ValidationCHD2
Huge Navigator CHD2 [HugePedia]
snp3D : Map Gene to Disease1106
BioCentury BCIQCHD2
ClinGenCHD2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1106
Chemical/Pharm GKB GenePA26453
Clinical trialCHD2
Miscellaneous
canSAR (ICR)CHD2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHD2
EVEXCHD2
GoPubMedCHD2
iHOPCHD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:07:35 CET 2017

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