Identity
HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CHD-4,Mi-2b,Mi2-BETA,SIHIWES
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1108
MIM: 603277
HGNC: 1919
Ensembl: ENSG00000111642
Variants:
dbSNP: 1108
ClinVar: 1108
TCGA: ENSG00000111642
COSMIC: CHD4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748224 | vorinostat | Chemical | MultilinkAnnotation | associated | 26296641 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37963210 | 2024 | The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture. | 2 |
| 38268032 | 2024 | Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. | 0 |
| 38281186 | 2024 | Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. | 0 |
| 38619323 | 2024 | CHD4 and SMYD1 repress common transcriptional programs in the developing heart. | 2 |
| 38761648 | 2024 | FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma. | 0 |
| 37963210 | 2024 | The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture. | 2 |
| 38268032 | 2024 | Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. | 0 |
| 38281186 | 2024 | Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. | 0 |
| 38619323 | 2024 | CHD4 and SMYD1 repress common transcriptional programs in the developing heart. | 2 |
| 38761648 | 2024 | FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma. | 0 |
| 36681835 | 2023 | The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer. | 5 |
| 36812914 | 2023 | Epigenetic regulation of plastin 3 expression by the macrosatellite DXZ4 and the transcriptional regulator CHD4. | 0 |
| 36913741 | 2023 | The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo. | 2 |
| 36995066 | 2023 | Dermatomyositis autoantigen CHD4 forms immune stimulatory complexes with endogenous DNA. | 0 |
| 37254794 | 2023 | Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1. | 3 |
Citation
Dessen P
CHD4 (chromodomain helicase DNA binding protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40072/chd4
