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CHEK1 (checkpoint kinase 1)

Identity

Alias (NCBI)CHK1
HGNC (Hugo) CHEK1
HGNC Alias symbCHK1
HGNC Previous nameCHK1 (checkpoint, S.pombe) homolog
 CHK1 checkpoint homolog (S. pombe)
LocusID (NCBI) 1111
Atlas_Id 210
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 125626224 and ends at 125657154 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHEK1 (11q24.2) / DCAF8 (1q23.2)CHEK1 (11q24.2) / EXOC6 (10q23.33)TMEM135 (11q14.2) / CHEK1 (11q24.2)
CHEK1 11q24.2 / EXOC6 10q23.33TMEM135 11q14.2 / CHEK1 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;11)(q23;q24) CHEK1/EXOC6
t(11;11)(q14;q24) TMEM135/CHEK1

External links

Nomenclature
HGNC (Hugo)CHEK1   1925
Cards
Entrez_Gene (NCBI)CHEK1    checkpoint kinase 1
AliasesCHK1
GeneCards (Weizmann)CHEK1
Ensembl hg19 (Hinxton)ENSG00000149554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149554 [Gene_View]  ENSG00000149554 [Sequence]  chr11:125626224-125657154 [Contig_View]  CHEK1 [Vega]
ICGC DataPortalENSG00000149554
TCGA cBioPortalCHEK1
AceView (NCBI)CHEK1
Genatlas (Paris)CHEK1
SOURCE (Princeton)CHEK1
Genetics Home Reference (NIH)CHEK1
Genomic and cartography
GoldenPath hg38 (UCSC)CHEK1  -     chr11:125626224-125657154 +  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHEK1  -     11q24.2   [Description]    (hg19-Feb_2009)
GoldenPathCHEK1 - 11q24.2 [CytoView hg19]  CHEK1 - 11q24.2 [CytoView hg38]
ImmunoBaseENSG00000149554
genome Data Viewer NCBICHEK1 [Mapview hg19]  
OMIM603078   
Gene and transcription
Genbank (Entrez)AA224205 AB451222 AB451345 AF016582 AF032874
RefSeq transcript (Entrez)NM_001114121 NM_001114122 NM_001244846 NM_001274 NM_001330427 NM_001330428
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHEK1
Alternative Splicing GalleryENSG00000149554
Gene ExpressionCHEK1 [ NCBI-GEO ]   CHEK1 [ EBI - ARRAY_EXPRESS ]   CHEK1 [ SEEK ]   CHEK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CHEK1 [ Firebrowse - Broad ]
GenevisibleExpression of CHEK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1111
GTEX Portal (Tissue expression)CHEK1
Human Protein AtlasENSG00000149554-CHEK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14757   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14757  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14757
Splice isoforms : SwissVarO14757
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO14757
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Chk1_catalytic_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CHEK1
Blocks (Seattle)CHEK1
PDB (RSDB)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
PDB Europe1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
PDB (PDBSum)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
PDB (IMB)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
Structural Biology KnowledgeBase1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
SCOP (Structural Classification of Proteins)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
CATH (Classification of proteins structures)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS    5F4N    5OOP    5OOR    5OOT    5OP2    5OP4    5OP5    5OP7    5OPB    5OPR    5OPS    5OPU    5OPV    5OQ5    5OQ6    5OQ7    5OQ8    5WI2    6FC8    6FCF    6FCK   
SuperfamilyO14757
Human Protein Atlas [tissue]ENSG00000149554-CHEK1 [tissue]
Peptide AtlasO14757
HPRD04356
IPIIPI00023664   IPI00973081   IPI01008883   IPI00909845   IPI00978454   IPI00981751   IPI00984333   IPI00983124   IPI00974222   
Protein Interaction databases
DIP (DOE-UCLA)O14757
IntAct (EBI)O14757
BioGRIDCHEK1
STRING (EMBL)CHEK1
ZODIACCHEK1
Ontologies - Pathways
QuickGOO14757
Ontology : AmiGODNA damage checkpoint  DNA damage checkpoint  chromosome, telomeric region  chromatin  condensed nuclear chromosome  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  apoptotic process  cellular response to DNA damage stimulus  DNA damage induced protein phosphorylation  cell cycle  regulation of double-strand break repair via homologous recombination  regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  kinase activity  peptidyl-threonine phosphorylation  protein domain specific binding  protein-containing complex  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  intracellular signal transduction  intracellular membrane-bounded organelle  positive regulation of cell cycle  negative regulation of mitotic nuclear division  regulation of mitotic centrosome separation  chromatin-mediated maintenance of transcription  negative regulation of G0 to G1 transition  cellular response to mechanical stimulus  signal transduction involved in G2 DNA damage checkpoint  replicative senescence  regulation of signal transduction by p53 class mediator  regulation of histone H3-K9 acetylation  
Ontology : EGO-EBIDNA damage checkpoint  DNA damage checkpoint  chromosome, telomeric region  chromatin  condensed nuclear chromosome  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  apoptotic process  cellular response to DNA damage stimulus  DNA damage induced protein phosphorylation  cell cycle  regulation of double-strand break repair via homologous recombination  regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  kinase activity  peptidyl-threonine phosphorylation  protein domain specific binding  protein-containing complex  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  intracellular signal transduction  intracellular membrane-bounded organelle  positive regulation of cell cycle  negative regulation of mitotic nuclear division  regulation of mitotic centrosome separation  chromatin-mediated maintenance of transcription  negative regulation of G0 to G1 transition  cellular response to mechanical stimulus  signal transduction involved in G2 DNA damage checkpoint  replicative senescence  regulation of signal transduction by p53 class mediator  regulation of histone H3-K9 acetylation  
Pathways : KEGGCell cycle    p53 signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkCHEK1
Atlas of Cancer Signalling NetworkCHEK1
Wikipedia pathwaysCHEK1
Orthology - Evolution
OrthoDB1111
GeneTree (enSembl)ENSG00000149554
Phylogenetic Trees/Animal Genes : TreeFamCHEK1
HOGENOMO14757
Homologs : HomoloGeneCHEK1
Homology/Alignments : Family Browser (UCSC)CHEK1
Gene fusions - Rearrangements
Fusion : MitelmanCHEK1/EXOC6 [11q24.2/10q23.33]  
Fusion : MitelmanTMEM135/CHEK1 [11q14.2/11q24.2]  
Fusion PortalCHEK1 11q24.2 EXOC6 10q23.33 OV
Fusion PortalTMEM135 11q14.2 CHEK1 11q24.2 BRCA
Fusion : QuiverCHEK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHEK1 [hg38]
dbVarCHEK1
ClinVarCHEK1
MonarchCHEK1
1000_GenomesCHEK1 
Exome Variant ServerCHEK1
GNOMAD BrowserENSG00000149554
Varsome BrowserCHEK1
Genomic Variants (DGV)CHEK1 [DGVbeta]
DECIPHERCHEK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHEK1 
Mutations
ICGC Data PortalCHEK1 
TCGA Data PortalCHEK1 
Broad Tumor PortalCHEK1
OASIS PortalCHEK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHEK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCHEK1
Mutations and Diseases : HGMDCHEK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHEK1
DgiDB (Drug Gene Interaction Database)CHEK1
DoCM (Curated mutations)CHEK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHEK1 (select a term)
intoGenCHEK1
Cancer3DCHEK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603078   
Orphanet
DisGeNETCHEK1
MedgenCHEK1
Genetic Testing Registry CHEK1
NextProtO14757 [Medical]
GENETestsCHEK1
Target ValidationCHEK1
Huge Navigator CHEK1 [HugePedia]
ClinGenCHEK1
Clinical trials, drugs, therapy
MyCancerGenomeCHEK1
Protein Interactions : CTD
Pharm GKB GenePA110
Pharm GKB PathwaysPA166115250   
PharosO14757
Clinical trialCHEK1
Miscellaneous
canSAR (ICR)CHEK1 (select the gene name)
HarmonizomeCHEK1
DataMed IndexCHEK1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCHEK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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