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CHEK1 (checkpoint kinase 1)

Identity

Alias_namesCHK1 (checkpoint, S.pombe) homolog
CHK1 checkpoint homolog (S. pombe)
Alias_symbol (synonym)CHK1
Other alias
HGNC (Hugo) CHEK1
LocusID (NCBI) 1111
Atlas_Id 210
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 125495031 and ends at 125546150 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHEK1 (11q24.2) / DCAF8 (1q23.2)CHEK1 (11q24.2) / EXOC6 (10q23.33)TMEM135 (11q14.2) / CHEK1 (11q24.2)
CHEK1 11q24.2 / EXOC6 10q23.33TMEM135 11q14.2 / CHEK1 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHEK1   1925
Cards
Entrez_Gene (NCBI)CHEK1  1111  checkpoint kinase 1
AliasesCHK1
GeneCards (Weizmann)CHEK1
Ensembl hg19 (Hinxton)ENSG00000149554 [Gene_View]  chr11:125495031-125546150 [Contig_View]  CHEK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000149554 [Gene_View]  chr11:125495031-125546150 [Contig_View]  CHEK1 [Vega]
ICGC DataPortalENSG00000149554
TCGA cBioPortalCHEK1
AceView (NCBI)CHEK1
Genatlas (Paris)CHEK1
WikiGenes1111
SOURCE (Princeton)CHEK1
Genetics Home Reference (NIH)CHEK1
Genomic and cartography
GoldenPath hg19 (UCSC)CHEK1  -     chr11:125495031-125546150 +  11q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CHEK1  -     11q24.2   [Description]    (hg38-Dec_2013)
EnsemblCHEK1 - 11q24.2 [CytoView hg19]  CHEK1 - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBICHEK1 [Mapview hg19]  CHEK1 [Mapview hg38]
OMIM603078   
Gene and transcription
Genbank (Entrez)AA224205 AB451222 AB451345 AF016582 AF032874
RefSeq transcript (Entrez)NM_001114121 NM_001114122 NM_001244846 NM_001274
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_030049 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CHEK1
Cluster EST : UnigeneHs.595920 [ NCBI ]
CGAP (NCI)Hs.595920
Alternative Splicing GalleryENSG00000149554
Gene ExpressionCHEK1 [ NCBI-GEO ]   CHEK1 [ EBI - ARRAY_EXPRESS ]   CHEK1 [ SEEK ]   CHEK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CHEK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1111
GTEX Portal (Tissue expression)CHEK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14757   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14757  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14757
Splice isoforms : SwissVarO14757
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO14757
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CHEK1
DMDM Disease mutations1111
Blocks (Seattle)CHEK1
PDB (SRS)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
PDB (PDBSum)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
PDB (IMB)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
PDB (RSDB)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
Structural Biology KnowledgeBase1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
SCOP (Structural Classification of Proteins)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
CATH (Classification of proteins structures)1IA8    1NVQ    1NVR    1NVS    1ZLT    1ZYS    2AYP    2BR1    2BRB    2BRG    2BRH    2BRM    2BRN    2BRO    2C3J    2C3K    2C3L    2CGU    2CGV    2CGW    2CGX    2E9N    2E9O    2E9P    2E9U    2E9V    2GDO    2GHG    2HOG    2HXL    2HXQ    2HY0    2QHM    2QHN    2R0U    2WMQ    2WMR    2WMS    2WMT    2WMU    2WMV    2WMW    2WMX    2X8D    2X8E    2X8I    2XEY    2XEZ    2XF0    2YDI    2YDJ    2YDK    2YER    2YEX    2YM3    2YM4    2YM5    2YM6    2YM7    2YM8    2YWP    3F9N    3JVR    3JVS    3NLB    3OT3    3OT8    3PA3    3PA4    3PA5    3TKH    3TKI    3U9N    4FSM    4FSN    4FSQ    4FSR    4FST    4FSU    4FSW    4FSY    4FSZ    4FT0    4FT3    4FT5    4FT7    4FT9    4FTA    4FTC    4FTI    4FTJ    4FTK    4FTL    4FTM    4FTN    4FTO    4FTQ    4FTR    4FTT    4FTU    4GH2    4HYH    4HYI    4JIK    4QYE    4QYF    4QYG    4QYH    4RVK    4RVL    4RVM    5DLS   
SuperfamilyO14757
Human Protein AtlasENSG00000149554
Peptide AtlasO14757
HPRD04356
IPIIPI00023664   IPI00973081   IPI01008883   IPI00909845   IPI00978454   IPI00981751   IPI00984333   IPI00983124   IPI00974222   
Protein Interaction databases
DIP (DOE-UCLA)O14757
IntAct (EBI)O14757
FunCoupENSG00000149554
BioGRIDCHEK1
STRING (EMBL)CHEK1
ZODIACCHEK1
Ontologies - Pathways
QuickGOO14757
Ontology : AmiGODNA damage checkpoint  DNA damage checkpoint  G2/M transition of mitotic cell cycle  chromosome, telomeric region  chromatin  condensed nuclear chromosome  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  extracellular space  nucleus  nucleoplasm  nucleoplasm  replication fork  centrosome  cytosol  DNA replication  DNA repair  cellular response to DNA damage stimulus  DNA damage induced protein phosphorylation  regulation of double-strand break repair via homologous recombination  regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  kinase activity  peptidyl-threonine phosphorylation  G2 DNA damage checkpoint  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  histone H3-T11 phosphorylation  regulation of cell proliferation  intracellular membrane-bounded organelle  negative regulation of mitotic nuclear division  regulation of mitotic centrosome separation  chromatin-mediated maintenance of transcription  cellular response to mechanical stimulus  replicative senescence  regulation of signal transduction by p53 class mediator  regulation of histone H3-K9 acetylation  
Ontology : EGO-EBIDNA damage checkpoint  DNA damage checkpoint  G2/M transition of mitotic cell cycle  chromosome, telomeric region  chromatin  condensed nuclear chromosome  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  extracellular space  nucleus  nucleoplasm  nucleoplasm  replication fork  centrosome  cytosol  DNA replication  DNA repair  cellular response to DNA damage stimulus  DNA damage induced protein phosphorylation  regulation of double-strand break repair via homologous recombination  regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  kinase activity  peptidyl-threonine phosphorylation  G2 DNA damage checkpoint  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  histone H3-T11 phosphorylation  regulation of cell proliferation  intracellular membrane-bounded organelle  negative regulation of mitotic nuclear division  regulation of mitotic centrosome separation  chromatin-mediated maintenance of transcription  cellular response to mechanical stimulus  replicative senescence  regulation of signal transduction by p53 class mediator  regulation of histone H3-K9 acetylation  
Pathways : BIOCARTAcdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes]    RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]    Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    Regulation of cell cycle progression by Plk3 [Genes]    ATM Signaling Pathway [Genes]   
Pathways : KEGGCell cycle    p53 signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkCHEK1
Atlas of Cancer Signalling NetworkCHEK1
Wikipedia pathwaysCHEK1
Orthology - Evolution
OrthoDB1111
GeneTree (enSembl)ENSG00000149554
Phylogenetic Trees/Animal Genes : TreeFamCHEK1
HOVERGENO14757
HOGENOMO14757
Homologs : HomoloGeneCHEK1
Homology/Alignments : Family Browser (UCSC)CHEK1
Gene fusions - Rearrangements
Fusion : MitelmanCHEK1/EXOC6 [11q24.2/10q23.33]  
Fusion : MitelmanTMEM135/CHEK1 [11q14.2/11q24.2]  [t(11;11)(q14;q24)]  
Fusion: TCGACHEK1 11q24.2 EXOC6 10q23.33 OV
Fusion: TCGATMEM135 11q14.2 CHEK1 11q24.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHEK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHEK1
dbVarCHEK1
ClinVarCHEK1
1000_GenomesCHEK1 
Exome Variant ServerCHEK1
ExAC (Exome Aggregation Consortium)CHEK1 (select the gene name)
Genetic variants : HAPMAP1111
Genomic Variants (DGV)CHEK1 [DGVbeta]
DECIPHER (Syndromes)11:125495031-125546150  ENSG00000149554
CONAN: Copy Number AnalysisCHEK1 
Mutations
ICGC Data PortalCHEK1 
TCGA Data PortalCHEK1 
Broad Tumor PortalCHEK1
OASIS PortalCHEK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHEK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHEK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHEK1
DgiDB (Drug Gene Interaction Database)CHEK1
DoCM (Curated mutations)CHEK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHEK1 (select a term)
intoGenCHEK1
Cancer3DCHEK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603078   
Orphanet
MedgenCHEK1
Genetic Testing Registry CHEK1
NextProtO14757 [Medical]
TSGene1111
GENETestsCHEK1
Huge Navigator CHEK1 [HugePedia]
snp3D : Map Gene to Disease1111
BioCentury BCIQCHEK1
ClinGenCHEK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1111
Chemical/Pharm GKB GenePA110
Clinical trialCHEK1
Miscellaneous
canSAR (ICR)CHEK1 (select the gene name)
Probes
Litterature
PubMed395 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHEK1
EVEXCHEK1
GoPubMedCHEK1
iHOPCHEK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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