CHEK1 (checkpoint kinase 1)

2003-02-01  

Identity

HGNC
LOCATION
11q24.2
LOCUSID
ALIAS
CHK1
FUSION GENES

Other Information

Locus ID:

NCBI: 1111
MIM: 603078
HGNC: 1925
Ensembl: ENSG00000149554

Variants:

dbSNP: 1111
ClinVar: 1111
TCGA: ENSG00000149554
COSMIC: CHEK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149554ENST00000278916O14757
ENSG00000149554ENST00000278916J3KN87
ENSG00000149554ENST00000427383E7EPP6
ENSG00000149554ENST00000428830O14757
ENSG00000149554ENST00000438015O14757
ENSG00000149554ENST00000524737O14757
ENSG00000149554ENST00000525396E9PRU7
ENSG00000149554ENST00000526937E9PJI4
ENSG00000149554ENST00000527013E9PKQ3
ENSG00000149554ENST00000531607A0A087WT52
ENSG00000149554ENST00000532449O14757
ENSG00000149554ENST00000532669E9PPA5
ENSG00000149554ENST00000534070O14757
ENSG00000149554ENST00000534685E9PQW7
ENSG00000149554ENST00000544373O14757

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
DNA damage-induced cell cycle checkpointsKEGGM00691
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Independent G1/S DNA damage checkpointREACTOMER-HSA-69613
p53-Independent DNA Damage ResponseREACTOMER-HSA-69610
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AREACTOMER-HSA-69601
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Activation of ATR in response to replication stressREACTOMER-HSA-176187
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA61ATMGenePathwayassociated
PA74ATRGenePathwayassociated
PA95CCNB1GenePathwayassociated

References

Pubmed IDYearTitleCitations
210349662010The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.381
92785111997Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.349
158314612005Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.226
126765832003Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.176
200680822010New insights into checkpoint kinase 1 in the DNA damage response signaling network.155
123995442002Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.140
157103312005Lack of PTEN sequesters CHK1 and initiates genetic instability.126
250867462014ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.116
157439072005ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.114
153112852004Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.113

Citation

Dessen P

CHEK1 (checkpoint kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/210/chek1