Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CHGA (chromogranin A)

Identity

Other aliasCGA
HGNC (Hugo) CHGA
LocusID (NCBI) 1113
Atlas_Id 40074
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 92923100 and ends at 92935296 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHGA (14q32.12) / CHGA (14q32.12)CHGA (14q32.12) / HGSNAT (8p11.21)CHGA (14q32.12) / RBM14 (11q13.2)
USP14 (18p11.32) / CHGA (14q32.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHGA   1929
Cards
Entrez_Gene (NCBI)CHGA  1113  chromogranin A
AliasesCGA
GeneCards (Weizmann)CHGA
Ensembl hg19 (Hinxton)ENSG00000100604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100604 [Gene_View]  ENSG00000100604 [Sequence]  chr14:92923100-92935296 [Contig_View]  CHGA [Vega]
ICGC DataPortalENSG00000100604
TCGA cBioPortalCHGA
AceView (NCBI)CHGA
Genatlas (Paris)CHGA
WikiGenes1113
SOURCE (Princeton)CHGA
Genetics Home Reference (NIH)CHGA
Genomic and cartography
GoldenPath hg38 (UCSC)CHGA  -     chr14:92923100-92935296 +  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHGA  -     14q32.12   [Description]    (hg19-Feb_2009)
EnsemblCHGA - 14q32.12 [CytoView hg19]  CHGA - 14q32.12 [CytoView hg38]
Mapping of homologs : NCBICHGA [Mapview hg19]  CHGA [Mapview hg38]
OMIM118910   
Gene and transcription
Genbank (Entrez)AK223381 AK313757 BC001059 BC006459 BC009384
RefSeq transcript (Entrez)NM_001275 NM_001301690
RefSeq genomic (Entrez)NC_000014 NT_187601
Consensus coding sequences : CCDS (NCBI)CHGA
Cluster EST : UnigeneHs.150793 [ NCBI ]
CGAP (NCI)Hs.150793
Alternative Splicing GalleryENSG00000100604
Gene ExpressionCHGA [ NCBI-GEO ]   CHGA [ EBI - ARRAY_EXPRESS ]   CHGA [ SEEK ]   CHGA [ MEM ]
Gene Expression Viewer (FireBrowse)CHGA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1113
GTEX Portal (Tissue expression)CHGA
Human Protein AtlasENSG00000100604-CHGA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10645   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10645  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10645
Splice isoforms : SwissVarP10645
PhosPhoSitePlusP10645
Domaine pattern : Prosite (Expaxy)GRANINS_1 (PS00422)    GRANINS_2 (PS00423)   
Domains : Interpro (EBI)Chromogranin_AB    Chromogranin_CS    Granin   
Domain families : Pfam (Sanger)Granin (PF01271)   
Domain families : Pfam (NCBI)pfam01271   
Conserved Domain (NCBI)CHGA
DMDM Disease mutations1113
Blocks (Seattle)CHGA
PDB (SRS)1LV4   
PDB (PDBSum)1LV4   
PDB (IMB)1LV4   
PDB (RSDB)1LV4   
Structural Biology KnowledgeBase1LV4   
SCOP (Structural Classification of Proteins)1LV4   
CATH (Classification of proteins structures)1LV4   
SuperfamilyP10645
Human Protein Atlas [tissue]ENSG00000100604-CHGA [tissue]
Peptide AtlasP10645
HPRD07170
IPIIPI00290315   IPI00383975   IPI01024944   IPI01026468   
Protein Interaction databases
DIP (DOE-UCLA)P10645
IntAct (EBI)P10645
FunCoupENSG00000100604
BioGRIDCHGA
STRING (EMBL)CHGA
ZODIACCHGA
Ontologies - Pathways
QuickGOP10645
Ontology : AmiGOregulation of the force of heart contraction  mast cell chemotaxis  extracellular region  extracellular space  extracellular space  organelle organization  regulation of blood pressure  antimicrobial humoral response  secretory granule  secretory granule  transport vesicle membrane  killing of cells of other organism  mast cell cytokine production  negative regulation of catecholamine secretion  negative regulation of catecholamine secretion  chromaffin granule  chromaffin granule  mast cell granule  mast cell degranulation  innate immune response  mast cell activation  negative regulation of insulin secretion  negative regulation of hormone secretion  perinuclear region of cytoplasm  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  defense response to fungus  positive regulation of cardiac muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation  adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation  negative regulation of blood vessel diameter  positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  negative regulation of neuron death  positive regulation of relaxation of cardiac muscle  positive regulation of dense core granule biogenesis  
Ontology : EGO-EBIregulation of the force of heart contraction  mast cell chemotaxis  extracellular region  extracellular space  extracellular space  organelle organization  regulation of blood pressure  antimicrobial humoral response  secretory granule  secretory granule  transport vesicle membrane  killing of cells of other organism  mast cell cytokine production  negative regulation of catecholamine secretion  negative regulation of catecholamine secretion  chromaffin granule  chromaffin granule  mast cell granule  mast cell degranulation  innate immune response  mast cell activation  negative regulation of insulin secretion  negative regulation of hormone secretion  perinuclear region of cytoplasm  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  defense response to fungus  positive regulation of cardiac muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation  adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation  negative regulation of blood vessel diameter  positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  negative regulation of neuron death  positive regulation of relaxation of cardiac muscle  positive regulation of dense core granule biogenesis  
NDEx NetworkCHGA
Atlas of Cancer Signalling NetworkCHGA
Wikipedia pathwaysCHGA
Orthology - Evolution
OrthoDB1113
GeneTree (enSembl)ENSG00000100604
Phylogenetic Trees/Animal Genes : TreeFamCHGA
HOVERGENP10645
HOGENOMP10645
Homologs : HomoloGeneCHGA
Homology/Alignments : Family Browser (UCSC)CHGA
Gene fusions - Rearrangements
Fusion : QuiverCHGA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHGA
dbVarCHGA
ClinVarCHGA
1000_GenomesCHGA 
Exome Variant ServerCHGA
ExAC (Exome Aggregation Consortium)ENSG00000100604
GNOMAD BrowserENSG00000100604
Varsome BrowserCHGA
Genetic variants : HAPMAP1113
Genomic Variants (DGV)CHGA [DGVbeta]
DECIPHERCHGA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHGA 
Mutations
ICGC Data PortalCHGA 
TCGA Data PortalCHGA 
Broad Tumor PortalCHGA
OASIS PortalCHGA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHGA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHGA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHGA
DgiDB (Drug Gene Interaction Database)CHGA
DoCM (Curated mutations)CHGA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHGA (select a term)
intoGenCHGA
Cancer3DCHGA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118910   
Orphanet
DisGeNETCHGA
MedgenCHGA
Genetic Testing Registry CHGA
NextProtP10645 [Medical]
TSGene1113
GENETestsCHGA
Target ValidationCHGA
Huge Navigator CHGA [HugePedia]
snp3D : Map Gene to Disease1113
BioCentury BCIQCHGA
ClinGenCHGA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1113
Chemical/Pharm GKB GenePA26461
Clinical trialCHGA
Miscellaneous
canSAR (ICR)CHGA (select the gene name)
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHGA
EVEXCHGA
GoPubMedCHGA
iHOPCHGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:58:06 CET 2018

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