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CHI3L2 (chitinase 3 like 2)

Identity

Alias (NCBI)CHIL2
YKL-39
YKL39
HGNC (Hugo) CHI3L2
HGNC Alias symbYKL-39
YKL39
HGNC Previous namechitinase 3-like 2
LocusID (NCBI) 1117
Atlas_Id 52915
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 111227713 and ends at 111243440 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AQP1 (7p14.3) / CHI3L2 (1p13.3)MUCL1 (12q13.2) / CHI3L2 (1p13.3)AQP1 7p14.3 / CHI3L2 1p13.3
MUCL1 12q13.2 / CHI3L2 1p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;7)(p13;p14) AQP1/CHI3L2
t(1;12)(p13;q13) MUCL1/CHI3L2

External links

Nomenclature
HGNC (Hugo)CHI3L2   1933
Cards
Entrez_Gene (NCBI)CHI3L2    chitinase 3 like 2
AliasesCHIL2; YKL-39; YKL39
GeneCards (Weizmann)CHI3L2
Ensembl hg19 (Hinxton)ENSG00000064886 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000064886 [Gene_View]  ENSG00000064886 [Sequence]  chr1:111227713-111243440 [Contig_View]  CHI3L2 [Vega]
ICGC DataPortalENSG00000064886
TCGA cBioPortalCHI3L2
AceView (NCBI)CHI3L2
Genatlas (Paris)CHI3L2
SOURCE (Princeton)CHI3L2
Genetics Home Reference (NIH)CHI3L2
Genomic and cartography
GoldenPath hg38 (UCSC)CHI3L2  -     chr1:111227713-111243440 +  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHI3L2  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathCHI3L2 - 1p13.2 [CytoView hg19]  CHI3L2 - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000064886
genome Data Viewer NCBICHI3L2 [Mapview hg19]  
OMIM601526   
Gene and transcription
Genbank (Entrez)AK223316 AK298466 BC011460 BG698401 BM787868
RefSeq transcript (Entrez)NM_001025197 NM_001025199 NM_004000
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHI3L2
Alternative Splicing GalleryENSG00000064886
Gene ExpressionCHI3L2 [ NCBI-GEO ]   CHI3L2 [ EBI - ARRAY_EXPRESS ]   CHI3L2 [ SEEK ]   CHI3L2 [ MEM ]
Gene Expression Viewer (FireBrowse)CHI3L2 [ Firebrowse - Broad ]
GenevisibleExpression of CHI3L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1117
GTEX Portal (Tissue expression)CHI3L2
Human Protein AtlasENSG00000064886-CHI3L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15782   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15782  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15782
Splice isoforms : SwissVarQ15782
PhosPhoSitePlusQ15782
Domaine pattern : Prosite (Expaxy)GH18_2 (PS51910)   
Domains : Interpro (EBI)CHI3L2    Chitinase_II    Chitinase_insertion_sf    Glyco_hydro18_cat    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_18 (PF00704)   
Domain families : Pfam (NCBI)pfam00704   
Domain families : Smart (EMBL)Glyco_18 (SM00636)  
Conserved Domain (NCBI)CHI3L2
Blocks (Seattle)CHI3L2
PDB (RSDB)4AY1    4P8U    4P8V    4P8W    4P8X   
PDB Europe4AY1    4P8U    4P8V    4P8W    4P8X   
PDB (PDBSum)4AY1    4P8U    4P8V    4P8W    4P8X   
PDB (IMB)4AY1    4P8U    4P8V    4P8W    4P8X   
Structural Biology KnowledgeBase4AY1    4P8U    4P8V    4P8W    4P8X   
SCOP (Structural Classification of Proteins)4AY1    4P8U    4P8V    4P8W    4P8X   
CATH (Classification of proteins structures)4AY1    4P8U    4P8V    4P8W    4P8X   
SuperfamilyQ15782
Human Protein Atlas [tissue]ENSG00000064886-CHI3L2 [tissue]
Peptide AtlasQ15782
HPRD03315
IPIIPI00019533   IPI00977027   IPI00978295   IPI00607646   IPI00979578   IPI00607669   IPI00984297   IPI00983614   IPI00977688   IPI00984767   IPI00980694   IPI00975844   
Protein Interaction databases
DIP (DOE-UCLA)Q15782
IntAct (EBI)Q15782
BioGRIDCHI3L2
STRING (EMBL)CHI3L2
ZODIACCHI3L2
Ontologies - Pathways
QuickGOQ15782
Ontology : AmiGOchitinase activity  chitinase activity  extracellular region  extracellular space  carbohydrate metabolic process  chitin catabolic process  chitin binding  chitin binding  carbohydrate binding  
Ontology : EGO-EBIchitinase activity  chitinase activity  extracellular region  extracellular space  carbohydrate metabolic process  chitin catabolic process  chitin binding  chitin binding  carbohydrate binding  
NDEx NetworkCHI3L2
Atlas of Cancer Signalling NetworkCHI3L2
Wikipedia pathwaysCHI3L2
Orthology - Evolution
OrthoDB1117
GeneTree (enSembl)ENSG00000064886
Phylogenetic Trees/Animal Genes : TreeFamCHI3L2
HOGENOMQ15782
Homologs : HomoloGeneCHI3L2
Homology/Alignments : Family Browser (UCSC)CHI3L2
Gene fusions - Rearrangements
Fusion : MitelmanAQP1/CHI3L2 [7p14.3/1p13.3]  
Fusion : MitelmanMUCL1/CHI3L2 [12q13.2/1p13.3]  
Fusion PortalAQP1 7p14.3 CHI3L2 1p13.3 LGG
Fusion PortalMUCL1 12q13.2 CHI3L2 1p13.3 BRCA
Fusion : QuiverCHI3L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHI3L2 [hg38]
dbVarCHI3L2
ClinVarCHI3L2
MonarchCHI3L2
1000_GenomesCHI3L2 
Exome Variant ServerCHI3L2
GNOMAD BrowserENSG00000064886
Varsome BrowserCHI3L2
Genomic Variants (DGV)CHI3L2 [DGVbeta]
DECIPHERCHI3L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHI3L2 
Mutations
ICGC Data PortalCHI3L2 
TCGA Data PortalCHI3L2 
Broad Tumor PortalCHI3L2
OASIS PortalCHI3L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHI3L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCHI3L2
Mutations and Diseases : HGMDCHI3L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHI3L2
DgiDB (Drug Gene Interaction Database)CHI3L2
DoCM (Curated mutations)CHI3L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHI3L2 (select a term)
intoGenCHI3L2
Cancer3DCHI3L2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601526   
Orphanet
DisGeNETCHI3L2
MedgenCHI3L2
Genetic Testing Registry CHI3L2
NextProtQ15782 [Medical]
GENETestsCHI3L2
Target ValidationCHI3L2
Huge Navigator CHI3L2 [HugePedia]
ClinGenCHI3L2
Clinical trials, drugs, therapy
MyCancerGenomeCHI3L2
Protein Interactions : CTD
Pharm GKB GenePA26464
PharosQ15782
Clinical trialCHI3L2
Miscellaneous
canSAR (ICR)CHI3L2 (select the gene name)
HarmonizomeCHI3L2
DataMed IndexCHI3L2
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCHI3L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:09:58 CET 2021
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