CHIA (chitinase acidic)

2014-11-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
AMCASE,CHIT2,TSA1902
FUSION GENES

Other Information

Locus ID:

NCBI: 27159
MIM: 606080
HGNC: 17432
Ensembl: ENSG00000134216

Variants:

dbSNP: 27159
ClinVar: 27159
TCGA: ENSG00000134216
COSMIC: CHIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134216ENST00000343320Q9BZP6
ENSG00000134216ENST00000352594H7BXH6
ENSG00000134216ENST00000353665Q9BZP6
ENSG00000134216ENST00000369740Q9BZP6
ENSG00000134216ENST00000422815Q5VUV5
ENSG00000134216ENST00000430615Q9BZP6
ENSG00000134216ENST00000451398Q9BZP6
ENSG00000134216ENST00000483391Q9BZP6
ENSG00000134216ENST00000489524E9PLJ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285571aspirin-induced asthmaDiseaseClinicalAnnotationassociatedPD
PA448497aspirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
151922322004Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.254
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
196443632009The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.42
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
186025732008Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.28
186025732008Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.28
194358882009Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.27
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
211597212011Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.21
193426902009Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.20

Citation

Dessen P

CHIA (chitinase acidic)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61796/chia