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CHIT1 (chitinase 1)

Identity

Alias_nameschitinase 1 (chitotriosidase)
Alias_symbol (synonym)CHIT
CHI3
Other aliasCHITD
HGNC (Hugo) CHIT1
LocusID (NCBI) 1118
Atlas_Id 43912
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203216079 and ends at 203229732 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NAA50 (3q13.2) / CHIT1 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHIT1   1936
Cards
Entrez_Gene (NCBI)CHIT1  1118  chitinase 1
AliasesCHI3; CHIT; CHITD
GeneCards (Weizmann)CHIT1
Ensembl hg19 (Hinxton)ENSG00000133063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133063 [Gene_View]  chr1:203216079-203229732 [Contig_View]  CHIT1 [Vega]
ICGC DataPortalENSG00000133063
TCGA cBioPortalCHIT1
AceView (NCBI)CHIT1
Genatlas (Paris)CHIT1
WikiGenes1118
SOURCE (Princeton)CHIT1
Genetics Home Reference (NIH)CHIT1
Genomic and cartography
GoldenPath hg38 (UCSC)CHIT1  -     chr1:203216079-203229732 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHIT1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblCHIT1 - 1q32.1 [CytoView hg19]  CHIT1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBICHIT1 [Mapview hg19]  CHIT1 [Mapview hg38]
OMIM600031   614122   
Gene and transcription
Genbank (Entrez)AI697695 AK055165 AK131093 AK225245 AK309341
RefSeq transcript (Entrez)NM_001256125 NM_001270509 NM_003465
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHIT1
Cluster EST : UnigeneHs.201688 [ NCBI ]
CGAP (NCI)Hs.201688
Alternative Splicing GalleryENSG00000133063
Gene ExpressionCHIT1 [ NCBI-GEO ]   CHIT1 [ EBI - ARRAY_EXPRESS ]   CHIT1 [ SEEK ]   CHIT1 [ MEM ]
Gene Expression Viewer (FireBrowse)CHIT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1118
GTEX Portal (Tissue expression)CHIT1
Human Protein AtlasENSG00000133063-CHIT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13231   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13231  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13231
Splice isoforms : SwissVarQ13231
Catalytic activity : Enzyme3.2.1.14 [ Enzyme-Expasy ]   3.2.1.143.2.1.14 [ IntEnz-EBI ]   3.2.1.14 [ BRENDA ]   3.2.1.14 [ KEGG ]   
PhosPhoSitePlusQ13231
Domaine pattern : Prosite (Expaxy)CHIT_BIND_II (PS50940)    CHITINASE_18 (PS01095)   
Domains : Interpro (EBI)Chitin-bd_dom    Chitinase_II    Chitinase_insertion    Glyco_hydro18_cat    Glyco_hydro_18_chit_AS    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)CBM_14 (PF01607)    Glyco_hydro_18 (PF00704)   
Domain families : Pfam (NCBI)pfam01607    pfam00704   
Domain families : Smart (EMBL)ChtBD2 (SM00494)  Glyco_18 (SM00636)  
Conserved Domain (NCBI)CHIT1
DMDM Disease mutations1118
Blocks (Seattle)CHIT1
PDB (SRS)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
PDB (PDBSum)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
PDB (IMB)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
PDB (RSDB)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
Structural Biology KnowledgeBase1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
SCOP (Structural Classification of Proteins)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
CATH (Classification of proteins structures)1GUV    1HKI    1HKJ    1HKK    1HKM    1LG1    1LG2    1LQ0    1WAW    1WB0    4WJX    4WK9    4WKA    4WKF    4WKH    5HBF   
SuperfamilyQ13231
Human Protein Atlas [tissue]ENSG00000133063-CHIT1 [tissue]
Peptide AtlasQ13231
HPRD02494
IPIIPI00478217   IPI00852865   IPI00375364   IPI00966316   IPI00442348   IPI00966620   
Protein Interaction databases
DIP (DOE-UCLA)Q13231
IntAct (EBI)Q13231
FunCoupENSG00000133063
BioGRIDCHIT1
STRING (EMBL)CHIT1
ZODIACCHIT1
Ontologies - Pathways
QuickGOQ13231
Ontology : AmiGOpolysaccharide catabolic process  hydrolase activity, hydrolyzing O-glycosyl compounds  chitinase activity  extracellular region  extracellular space  extracellular space  lysosome  carbohydrate metabolic process  chitin catabolic process  chitin catabolic process  immune response  chitin binding  endochitinase activity  response to bacterium  specific granule lumen  neutrophil degranulation  tertiary granule lumen  
Ontology : EGO-EBIpolysaccharide catabolic process  hydrolase activity, hydrolyzing O-glycosyl compounds  chitinase activity  extracellular region  extracellular space  extracellular space  lysosome  carbohydrate metabolic process  chitin catabolic process  chitin catabolic process  immune response  chitin binding  endochitinase activity  response to bacterium  specific granule lumen  neutrophil degranulation  tertiary granule lumen  
Pathways : KEGGAmino sugar and nucleotide sugar metabolism   
NDEx NetworkCHIT1
Atlas of Cancer Signalling NetworkCHIT1
Wikipedia pathwaysCHIT1
Orthology - Evolution
OrthoDB1118
GeneTree (enSembl)ENSG00000133063
Phylogenetic Trees/Animal Genes : TreeFamCHIT1
HOVERGENQ13231
HOGENOMQ13231
Homologs : HomoloGeneCHIT1
Homology/Alignments : Family Browser (UCSC)CHIT1
Gene fusions - Rearrangements
Tumor Fusion PortalCHIT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHIT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHIT1
dbVarCHIT1
ClinVarCHIT1
1000_GenomesCHIT1 
Exome Variant ServerCHIT1
ExAC (Exome Aggregation Consortium)ENSG00000133063
GNOMAD BrowserENSG00000133063
Genetic variants : HAPMAP1118
Genomic Variants (DGV)CHIT1 [DGVbeta]
DECIPHERCHIT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHIT1 
Mutations
ICGC Data PortalCHIT1 
TCGA Data PortalCHIT1 
Broad Tumor PortalCHIT1
OASIS PortalCHIT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHIT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHIT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch CHIT1
DgiDB (Drug Gene Interaction Database)CHIT1
DoCM (Curated mutations)CHIT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHIT1 (select a term)
intoGenCHIT1
Cancer3DCHIT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600031    614122   
Orphanet
DisGeNETCHIT1
MedgenCHIT1
Genetic Testing Registry CHIT1
NextProtQ13231 [Medical]
TSGene1118
GENETestsCHIT1
Target ValidationCHIT1
Huge Navigator CHIT1 [HugePedia]
snp3D : Map Gene to Disease1118
BioCentury BCIQCHIT1
ClinGenCHIT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1118
Chemical/Pharm GKB GenePA26467
Clinical trialCHIT1
Miscellaneous
canSAR (ICR)CHIT1 (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHIT1
EVEXCHIT1
GoPubMedCHIT1
iHOPCHIT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:07:39 CET 2017

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