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CHKB (choline kinase beta)

Identity

Other namesCHETK
CHKL
CK
CKB
CKEKB
EK
EKB
MDCMC
HGNC (Hugo) CHKB
LocusID (NCBI) 1120
Atlas_Id 51457
Location 22q13.33
Location_base_pair Starts at 51017387 and ends at 51021428 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CHKB   1938
Cards
Entrez_Gene (NCBI)CHKB  1120  choline kinase beta
GeneCards (Weizmann)CHKB
Ensembl hg19 (Hinxton)ENSG00000100288 [Gene_View]  chr22:51017387-51021428 [Contig_View]  CHKB [Vega]
Ensembl hg38 (Hinxton)ENSG00000100288 [Gene_View]  chr22:51017387-51021428 [Contig_View]  CHKB [Vega]
ICGC DataPortalENSG00000100288
TCGA cBioPortalCHKB
AceView (NCBI)CHKB
Genatlas (Paris)CHKB
WikiGenes1120
SOURCE (Princeton)CHKB
Genomic and cartography
GoldenPath hg19 (UCSC)CHKB  -     chr22:51017387-51021428 -  22q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CHKB  -     22q13.33   [Description]    (hg38-Dec_2013)
EnsemblCHKB - 22q13.33 [CytoView hg19]  CHKB - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBICHKB [Mapview hg19]  CHKB [Mapview hg38]
OMIM602541   612395   
Gene and transcription
Genbank (Entrez)AB029886 AK097775 AK314324 AL096780 AL096781
RefSeq transcript (Entrez)NM_005198 NM_152253
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_012643 NG_029213 NT_011526 NW_004929431
Consensus coding sequences : CCDS (NCBI)CHKB
Cluster EST : UnigeneHs.654827 [ NCBI ]
CGAP (NCI)Hs.654827
Alternative Splicing : Fast-db (Paris)GSHG0020525
Alternative Splicing GalleryENSG00000100288
Gene ExpressionCHKB [ NCBI-GEO ]     CHKB [ SEEK ]   CHKB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y259 (Uniprot)
NextProtQ9Y259  [Medical]
With graphics : InterProQ9Y259
Splice isoforms : SwissVarQ9Y259 (Swissvar)
Catalytic activity : Enzyme2.7.1.32 [ Enzyme-Expasy ]   2.7.1.322.7.1.32 [ IntEnz-EBI ]   2.7.1.32 [ BRENDA ]   2.7.1.32 [ KEGG ]   
Domains : Interpro (EBI)Kinase-like_dom   
Related proteins : CluSTrQ9Y259
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations1120
Blocks (Seattle)Q9Y259
PDB (SRS)2IG7    3FEG    3LQ3   
PDB (PDBSum)2IG7    3FEG    3LQ3   
PDB (IMB)2IG7    3FEG    3LQ3   
PDB (RSDB)2IG7    3FEG    3LQ3   
Human Protein AtlasENSG00000100288
Peptide AtlasQ9Y259
HPRD07631
IPIIPI00031758   IPI00376947   IPI00815846   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y259
IntAct (EBI)Q9Y259
FunCoupENSG00000100288
BioGRIDCHKB
IntegromeDBCHKB
STRING (EMBL)CHKB
Ontologies - Pathways
QuickGOQ9Y259
Ontology : AmiGOcholine kinase activity  ethanolamine kinase activity  ATP binding  cytosol  phospholipid metabolic process  phosphatidylethanolamine biosynthetic process  phosphatidylethanolamine biosynthetic process  phosphatidylethanolamine biosynthetic process  phosphatidylcholine biosynthetic process  CDP-choline pathway  CDP-choline pathway  phosphorylation  small molecule metabolic process  glycerophospholipid biosynthetic process  
Ontology : EGO-EBIcholine kinase activity  ethanolamine kinase activity  ATP binding  cytosol  phospholipid metabolic process  phosphatidylethanolamine biosynthetic process  phosphatidylethanolamine biosynthetic process  phosphatidylethanolamine biosynthetic process  phosphatidylcholine biosynthetic process  CDP-choline pathway  CDP-choline pathway  phosphorylation  small molecule metabolic process  glycerophospholipid biosynthetic process  
Pathways : KEGGGlycerophospholipid metabolism   
Protein Interaction DatabaseCHKB
DoCM (Curated mutations)CHKB
Wikipedia pathwaysCHKB
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerCHKB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHKB
dbVarCHKB
ClinVarCHKB
1000_GenomesCHKB 
Exome Variant ServerCHKB
SNP (GeneSNP Utah)CHKB
SNP : HGBaseCHKB
Genetic variants : HAPMAPCHKB
Genomic Variants (DGV)CHKB [DGVbeta]
Mutations
ICGC Data PortalCHKB 
TCGA Data PortalCHKB 
Tumor PortalCHKB
Somatic Mutations in Cancer : COSMICCHKB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:51017387-51021428
CONAN: Copy Number AnalysisCHKB 
Mutations and Diseases : HGMDCHKB
OMIM602541    612395   
MedgenCHKB
NextProtQ9Y259 [Medical]
GENETestsCHKB
Disease Genetic AssociationCHKB
Huge Navigator CHKB [HugePedia]  CHKB [HugeCancerGEM]
snp3D : Map Gene to Disease1120
DGIdb (Drug Gene Interaction db)CHKB
General knowledge
Homologs : HomoloGeneCHKB
Homology/Alignments : Family Browser (UCSC)CHKB
Phylogenetic Trees/Animal Genes : TreeFamCHKB
Chemical/Protein Interactions : CTD1120
Chemical/Pharm GKB GenePA26469
Clinical trialCHKB
Cancer Resource (Charite)ENSG00000100288
Other databases
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
CoreMineCHKB
GoPubMedCHKB
iHOPCHKB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:12:41 CEST 2015

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