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CHMP4B (charged multivesicular body protein 4B)

Identity

Alias_namesC20orf178
chromosome 20 open reading frame 178
chromatin modifying protein 4B
Alias_symbol (synonym)dJ553F4.4
Shax1
SNF7-2
VPS32B
Other aliasCHMP4A
CTPP3
CTRCT31
SNF7
Vps32-2
HGNC (Hugo) CHMP4B
LocusID (NCBI) 128866
Atlas_Id 61806
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 33811304 and ends at 33854367 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHMP4B (20q11.22) / CBFA2T2 (20q11.21)CHMP4B (20q11.22) / FBXO34 (14q22.3)CHMP4B (20q11.22) / NCOA6 (20q11.22)
CHMP4B (20q11.22) / PIGU (20q11.22)CHMP4B (20q11.22) / RBPMS2 (15q22.31)CTSD (11p15.5) / CHMP4B (20q11.22)
KRT7 (12q13.13) / CHMP4B (20q11.22)TOB1 (17q21.33) / CHMP4B (20q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHMP4B   16171
Cards
Entrez_Gene (NCBI)CHMP4B  128866  charged multivesicular body protein 4B
AliasesC20orf178; CHMP4A; CTPP3; CTRCT31; 
SNF7; SNF7-2; Shax1; VPS32B; Vps32-2; dJ553F4.4
GeneCards (Weizmann)CHMP4B
Ensembl hg19 (Hinxton)ENSG00000101421 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101421 [Gene_View]  chr20:33811304-33854367 [Contig_View]  CHMP4B [Vega]
ICGC DataPortalENSG00000101421
TCGA cBioPortalCHMP4B
AceView (NCBI)CHMP4B
Genatlas (Paris)CHMP4B
WikiGenes128866
SOURCE (Princeton)CHMP4B
Genetics Home Reference (NIH)CHMP4B
Genomic and cartography
GoldenPath hg38 (UCSC)CHMP4B  -     chr20:33811304-33854367 +  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHMP4B  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblCHMP4B - 20q11.22 [CytoView hg19]  CHMP4B - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBICHMP4B [Mapview hg19]  CHMP4B [Mapview hg38]
OMIM605387   610897   
Gene and transcription
Genbank (Entrez)AB100261 AY329085 AY726594 BC033859 BQ926070
RefSeq transcript (Entrez)NM_176812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHMP4B
Cluster EST : UnigeneHs.472471 [ NCBI ]
CGAP (NCI)Hs.472471
Alternative Splicing GalleryENSG00000101421
Gene ExpressionCHMP4B [ NCBI-GEO ]   CHMP4B [ EBI - ARRAY_EXPRESS ]   CHMP4B [ SEEK ]   CHMP4B [ MEM ]
Gene Expression Viewer (FireBrowse)CHMP4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128866
GTEX Portal (Tissue expression)CHMP4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H444   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H444  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H444
Splice isoforms : SwissVarQ9H444
PhosPhoSitePlusQ9H444
Domains : Interpro (EBI)Snf7_fam   
Domain families : Pfam (Sanger)Snf7 (PF03357)   
Domain families : Pfam (NCBI)pfam03357   
Conserved Domain (NCBI)CHMP4B
DMDM Disease mutations128866
Blocks (Seattle)CHMP4B
PDB (SRS)3C3Q    3UM3    4ABM   
PDB (PDBSum)3C3Q    3UM3    4ABM   
PDB (IMB)3C3Q    3UM3    4ABM   
PDB (RSDB)3C3Q    3UM3    4ABM   
Structural Biology KnowledgeBase3C3Q    3UM3    4ABM   
SCOP (Structural Classification of Proteins)3C3Q    3UM3    4ABM   
CATH (Classification of proteins structures)3C3Q    3UM3    4ABM   
SuperfamilyQ9H444
Human Protein AtlasENSG00000101421
Peptide AtlasQ9H444
HPRD16642
IPIIPI00025974   
Protein Interaction databases
DIP (DOE-UCLA)Q9H444
IntAct (EBI)Q9H444
FunCoupENSG00000101421
BioGRIDCHMP4B
STRING (EMBL)CHMP4B
ZODIACCHMP4B
Ontologies - Pathways
QuickGOQ9H444
Ontology : AmiGOmitotic cytokinesis  ESCRT III complex  ESCRT III complex  cell separation after cytokinesis  protein binding  nucleus  nuclear envelope  cytoplasm  endosome  cytosol  posttranslational protein targeting to endoplasmic reticulum membrane  autophagy  autophagy  nucleus organization  vacuolar transport  mitotic metaphase plate congression  cytoplasmic side of plasma membrane  exit from mitosis  regulation of centrosome duplication  endosomal transport  macroautophagy  viral life cycle  membrane coat  midbody  nuclear envelope reassembly  late endosome membrane  vesicle  multivesicular body assembly  maintenance of lens transparency  viral budding via host ESCRT complex  viral budding via host ESCRT complex  viral budding via host ESCRT complex  identical protein binding  identical protein binding  protein homodimerization activity  cadherin binding  viral budding  regulation of viral process  protein homooligomerization  negative regulation of cell death  extracellular exosome  membrane fission  ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway  negative regulation of neuron death  regulation of mitotic spindle assembly  positive regulation of viral release from host cell  negative regulation of autophagosome assembly  
Ontology : EGO-EBImitotic cytokinesis  ESCRT III complex  ESCRT III complex  cell separation after cytokinesis  protein binding  nucleus  nuclear envelope  cytoplasm  endosome  cytosol  posttranslational protein targeting to endoplasmic reticulum membrane  autophagy  autophagy  nucleus organization  vacuolar transport  mitotic metaphase plate congression  cytoplasmic side of plasma membrane  exit from mitosis  regulation of centrosome duplication  endosomal transport  macroautophagy  viral life cycle  membrane coat  midbody  nuclear envelope reassembly  late endosome membrane  vesicle  multivesicular body assembly  maintenance of lens transparency  viral budding via host ESCRT complex  viral budding via host ESCRT complex  viral budding via host ESCRT complex  identical protein binding  identical protein binding  protein homodimerization activity  cadherin binding  viral budding  regulation of viral process  protein homooligomerization  negative regulation of cell death  extracellular exosome  membrane fission  ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway  negative regulation of neuron death  regulation of mitotic spindle assembly  positive regulation of viral release from host cell  negative regulation of autophagosome assembly  
Pathways : KEGGEndocytosis   
NDEx NetworkCHMP4B
Atlas of Cancer Signalling NetworkCHMP4B
Wikipedia pathwaysCHMP4B
Orthology - Evolution
OrthoDB128866
GeneTree (enSembl)ENSG00000101421
Phylogenetic Trees/Animal Genes : TreeFamCHMP4B
HOVERGENQ9H444
HOGENOMQ9H444
Homologs : HomoloGeneCHMP4B
Homology/Alignments : Family Browser (UCSC)CHMP4B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHMP4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHMP4B
dbVarCHMP4B
ClinVarCHMP4B
1000_GenomesCHMP4B 
Exome Variant ServerCHMP4B
ExAC (Exome Aggregation Consortium)CHMP4B (select the gene name)
Genetic variants : HAPMAP128866
Genomic Variants (DGV)CHMP4B [DGVbeta]
DECIPHERCHMP4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHMP4B 
Mutations
ICGC Data PortalCHMP4B 
TCGA Data PortalCHMP4B 
Broad Tumor PortalCHMP4B
OASIS PortalCHMP4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHMP4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHMP4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch CHMP4B
DgiDB (Drug Gene Interaction Database)CHMP4B
DoCM (Curated mutations)CHMP4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHMP4B (select a term)
intoGenCHMP4B
Cancer3DCHMP4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605387    610897   
Orphanet23422    14010   
MedgenCHMP4B
Genetic Testing Registry CHMP4B
NextProtQ9H444 [Medical]
TSGene128866
GENETestsCHMP4B
Target ValidationCHMP4B
Huge Navigator CHMP4B [HugePedia]
snp3D : Map Gene to Disease128866
BioCentury BCIQCHMP4B
ClinGenCHMP4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD128866
Chemical/Pharm GKB GenePA25721
Clinical trialCHMP4B
Miscellaneous
canSAR (ICR)CHMP4B (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHMP4B
EVEXCHMP4B
GoPubMedCHMP4B
iHOPCHMP4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:12:18 CEST 2017

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