CHMP4B (charged multivesicular body protein 4B)

2014-11-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf178,CHMP4A,CTPP3,CTRCT31,SNF7,SNF7-2,Shax1,VPS32B,Vps32-2,dJ553F4.4
FUSION GENES

Other Information

Locus ID:

NCBI: 128866
MIM: 610897
HGNC: 16171
Ensembl: ENSG00000101421

Variants:

dbSNP: 128866
ClinVar: 128866
TCGA: ENSG00000101421
COSMIC: CHMP4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101421ENST00000217402Q9H444

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-III complexKEGGhsa_M00412
ESCRT-III complexKEGGM00412
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182091002008Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.204
185115622008ALIX-CHMP4 interactions in the human ESCRT pathway.91
174288612007Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.87
128609942003The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.80
177019052007CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q.55
269294492016ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission.33
224066772012CC2D1A is a regulator of ESCRT-III CHMP4B.24
181905282008Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4).16
190166542009The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix.14
222582542012Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A.14

Citation

Dessen P

CHMP4B (charged multivesicular body protein 4B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61806/chmp4b