CHMP6 (charged multivesicular body protein 6)

2014-11-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
VPS20

Other Information

Locus ID:

NCBI: 79643
MIM: 610901
HGNC: 25675
Ensembl: ENSG00000176108

Variants:

dbSNP: 79643
ClinVar: 79643
TCGA: ENSG00000176108
COSMIC: CHMP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176108ENST00000325167Q96FZ7
ENSG00000176108ENST00000571457I3L4G8
ENSG00000176108ENST00000572525I3L3E4
ENSG00000176108ENST00000572778I3L4A1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-III complexKEGGhsa_M00412
ESCRT-III complexKEGGM00412
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196866842009Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.54
252320112014Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death.14
222314492012CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling.13
255886142015The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation.12
192703652009Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells.3

Citation

Dessen P

CHMP6 (charged multivesicular body protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61807/chmp6