CHMP7 (charged multivesicular body protein 7)

2014-11-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 91782
MIM: 611130
HGNC: 28439
Ensembl: ENSG00000147457

Variants:

dbSNP: 91782
ClinVar: 91782
TCGA: ENSG00000147457
COSMIC: CHMP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147457ENST00000313219Q8WUX9
ENSG00000147457ENST00000397677Q8WUX9
ENSG00000147457ENST00000517325E5RFR8
ENSG00000147457ENST00000519414E5RJI3
ENSG00000147457ENST00000519503Q8WUX9
ENSG00000147457ENST00000519984E5RIU9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-III complexKEGGhsa_M00412
ESCRT-III complexKEGGM00412
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177118582007The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.63
282426922017LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.30
276182632016Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.24
168568782006CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway.21
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6

Citation

Dessen P

CHMP7 (charged multivesicular body protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61808/chmp7