Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CHN1 (chimerin 1)

Identity

Other namesARHGAP2
CHN
DURS2
NC
RHOGAP2
HGNC (Hugo) CHN1
LocusID (NCBI) 1123
Location 2q31.1
Location_base_pair Starts at 175664042 and ends at 175870107 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CHN1   1943
Cards
Entrez_Gene (NCBI)CHN1  1123  chimerin 1
GeneCards (Weizmann)CHN1
Ensembl (Hinxton)ENSG00000128656 [Gene_View]  chr2:175664042-175870107 [Contig_View]  CHN1 [Vega]
ICGC DataPortalENSG00000128656
cBioPortalCHN1
AceView (NCBI)CHN1
Genatlas (Paris)CHN1
WikiGenes1123
SOURCE (Princeton)NM_001025201 NM_001206602 NM_001822
Genomic and cartography
GoldenPath (UCSC)CHN1  -  2q31.1   chr2:175664042-175870107 -  2q31.1   [Description]    (hg19-Feb_2009)
EnsemblCHN1 - 2q31.1 [CytoView]
Mapping of homologs : NCBICHN1 [Mapview]
OMIM118423   604356   
Gene and transcription
Genbank (Entrez)AB209788 AK055060 AK289941 AK300890 BC011393
RefSeq transcript (Entrez)NM_001025201 NM_001206602 NM_001822
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012642 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)CHN1
Cluster EST : UnigeneHs.380138 [ NCBI ]
CGAP (NCI)Hs.380138
Alternative Splicing : Fast-db (Paris)GSHG0018167
Alternative Splicing GalleryENSG00000128656
Gene ExpressionCHN1 [ NCBI-GEO ]     CHN1 [ SEEK ]   CHN1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15882 (Uniprot)
NextProtP15882  [Medical]
With graphics : InterProP15882
Splice isoforms : SwissVarP15882 (Swissvar)
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)    SH2 (PS50001)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd [organisation]   N-chimaerin [organisation]   Prot_Kinase_C-like_PE/DAG-bd [organisation]   Rho_GTPase_activation_prot [organisation]   RhoGAP_dom [organisation]   SH2 [organisation]  
Related proteins : CluSTrP15882
Domain families : Pfam (Sanger)C1_1 (PF00130)    RhoGAP (PF00620)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00130    pfam00620    pfam00017   
Domain families : Smart (EMBL)C1 (SM00109)  RhoGAP (SM00324)  SH2 (SM00252)  
DMDM Disease mutations1123
Blocks (Seattle)P15882
PDB (SRS)2OSA    3CXL   
PDB (PDBSum)2OSA    3CXL   
PDB (IMB)2OSA    3CXL   
PDB (RSDB)2OSA    3CXL   
Human Protein AtlasENSG00000128656 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP15882
HPRD00319
IPIIPI00013488   IPI00221041   IPI00910824   IPI00917235   IPI00917357   IPI00916361   IPI00916715   IPI00916084   IPI00916484   IPI00917444   IPI00917288   
Protein Interaction databases
DIP (DOE-UCLA)P15882
IntAct (EBI)P15882
FunCoupENSG00000128656
BioGRIDCHN1
InParanoidP15882
Interologous Interaction database P15882
IntegromeDBCHN1
STRING (EMBL)CHN1
Ontologies - Pathways
Ontology : AmiGOSH3/SH2 adaptor activity  GTPase activator activity  cytosol  small GTPase mediated signal transduction  motor neuron axon guidance  positive regulation of signal transduction  regulation of Rac GTPase activity  positive regulation of GTPase activity  metal ion binding  ephrin receptor binding  ephrin receptor signaling pathway  regulation of axonogenesis  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBISH3/SH2 adaptor activity  GTPase activator activity  cytosol  small GTPase mediated signal transduction  motor neuron axon guidance  positive regulation of signal transduction  regulation of Rac GTPase activity  positive regulation of GTPase activity  metal ion binding  ephrin receptor binding  ephrin receptor signaling pathway  regulation of axonogenesis  regulation of small GTPase mediated signal transduction  
Pathways : BIOCARTARac 1 cell motility signaling pathway [Genes]   
Protein Interaction DatabaseCHN1
Wikipedia pathwaysCHN1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CHN1
snp3D : Map Gene to Disease1123
SNP (GeneSNP Utah)CHN1
SNP : HGBaseCHN1
Genetic variants : HAPMAPCHN1
Exome VariantCHN1
1000_GenomesCHN1 
ICGC programENSG00000128656 
Cancer Gene: CensusCHN1 
Somatic Mutations in Cancer : COSMICCHN1 
CONAN: Copy Number AnalysisCHN1 
Mutations and Diseases : HGMDCHN1
Mutations and Diseases : intOGenCHN1
Genomic VariantsCHN1  CHN1 [DGVbeta]
dbVarCHN1
ClinVarCHN1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM118423    604356   
MedgenCHN1
GENETestsCHN1
Disease Genetic AssociationCHN1
Huge Navigator CHN1 [HugePedia]  CHN1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCHN1
Homology/Alignments : Family Browser (UCSC)CHN1
Phylogenetic Trees/Animal Genes : TreeFamCHN1
Chemical/Protein Interactions : CTD1123
Chemical/Pharm GKB GenePA26473
Clinical trialCHN1
Cancer Resource (Charite)ENSG00000128656
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineCHN1
iHOPCHN1
OncoSearchCHN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:42:11 CEST 2014

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