Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CHN2 (chimerin 2)

Identity

Alias_nameschimerin (chimaerin) 2
Alias_symbol (synonym)ARHGAP3
RhoGAP3
Other aliasBCH
CHN2-3
RHOGAP3
HGNC (Hugo) CHN2
LocusID (NCBI) 1124
Atlas_Id 43212
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 29519328 and ends at 29553951 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANK3 (10q21.2) / CHN2 (7p14.3)CHN2 (7p14.3) / INSR (19p13.2)CPSF7 (11q12.2) / CHN2 (7p14.3)
WHSC1 (4p16.3) / CHN2 (7p14.3)ANK3 10q21.2 / CHN2 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  i(7)(q10)


External links

Nomenclature
HGNC (Hugo)CHN2   1944
Cards
Entrez_Gene (NCBI)CHN2  1124  chimerin 2
AliasesARHGAP3; BCH; CHN2-3; RHOGAP3
GeneCards (Weizmann)CHN2
Ensembl hg19 (Hinxton)ENSG00000106069 [Gene_View]  chr7:29519328-29553951 [Contig_View]  CHN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106069 [Gene_View]  chr7:29519328-29553951 [Contig_View]  CHN2 [Vega]
ICGC DataPortalENSG00000106069
TCGA cBioPortalCHN2
AceView (NCBI)CHN2
Genatlas (Paris)CHN2
WikiGenes1124
SOURCE (Princeton)CHN2
Genetics Home Reference (NIH)CHN2
Genomic and cartography
GoldenPath hg19 (UCSC)CHN2  -     chr7:29519328-29553951 +  7p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CHN2  -     7p14.3   [Description]    (hg38-Dec_2013)
EnsemblCHN2 - 7p14.3 [CytoView hg19]  CHN2 - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBICHN2 [Mapview hg19]  CHN2 [Mapview hg38]
OMIM602857   
Gene and transcription
Genbank (Entrez)AA521339 AK026415 AK124021 AK126784 AK293959
RefSeq transcript (Entrez)NM_001039936 NM_001293069 NM_001293070 NM_001293071 NM_001293072 NM_001293073 NM_001293075 NM_001293076 NM_001293077 NM_001293078 NM_001293079 NM_001293080 NM_001293081 NM_004067
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029365 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)CHN2
Cluster EST : UnigeneHs.734596 [ NCBI ]
CGAP (NCI)Hs.734596
Alternative Splicing GalleryENSG00000106069
Gene ExpressionCHN2 [ NCBI-GEO ]   CHN2 [ EBI - ARRAY_EXPRESS ]   CHN2 [ SEEK ]   CHN2 [ MEM ]
Gene Expression Viewer (FireBrowse)CHN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1124
GTEX Portal (Tissue expression)CHN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52757   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52757  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52757
Splice isoforms : SwissVarP52757
PhosPhoSitePlusP52757
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)    SH2 (PS50001)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)CHN1/CHN2    DAG/PE-bd    PE/DAG-bd    Rho_GTPase_activation_prot    RhoGAP_dom    SH2   
Domain families : Pfam (Sanger)C1_1 (PF00130)    RhoGAP (PF00620)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00130    pfam00620    pfam00017   
Domain families : Smart (EMBL)C1 (SM00109)  RhoGAP (SM00324)  SH2 (SM00252)  
Conserved Domain (NCBI)CHN2
DMDM Disease mutations1124
Blocks (Seattle)CHN2
PDB (SRS)1XA6   
PDB (PDBSum)1XA6   
PDB (IMB)1XA6   
PDB (RSDB)1XA6   
Structural Biology KnowledgeBase1XA6   
SCOP (Structural Classification of Proteins)1XA6   
CATH (Classification of proteins structures)1XA6   
SuperfamilyP52757
Human Protein AtlasENSG00000106069
Peptide AtlasP52757
HPRD04173
IPIIPI01012038   IPI00903080   IPI00903036   IPI00902497   IPI00902851   IPI01010073   IPI01008895   IPI00903347   IPI01014494   IPI01016015   IPI00917968   IPI00902934   IPI00745327   IPI00747750   IPI00915934   IPI00915784   
Protein Interaction databases
DIP (DOE-UCLA)P52757
IntAct (EBI)P52757
FunCoupENSG00000106069
BioGRIDCHN2
STRING (EMBL)CHN2
ZODIACCHN2
Ontologies - Pathways
QuickGOP52757
Ontology : AmiGOSH3/SH2 adaptor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  positive regulation of signal transduction  membrane  intracellular signal transduction  positive regulation of GTPase activity  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBISH3/SH2 adaptor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  positive regulation of signal transduction  membrane  intracellular signal transduction  positive regulation of GTPase activity  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
NDEx NetworkCHN2
Atlas of Cancer Signalling NetworkCHN2
Wikipedia pathwaysCHN2
Orthology - Evolution
OrthoDB1124
GeneTree (enSembl)ENSG00000106069
Phylogenetic Trees/Animal Genes : TreeFamCHN2
HOVERGENP52757
HOGENOMP52757
Homologs : HomoloGeneCHN2
Homology/Alignments : Family Browser (UCSC)CHN2
Gene fusions - Rearrangements
Fusion : MitelmanANK3/CHN2 [10q21.2/7p14.3]  [t(7;10)(p14;q21)]  
Fusion: TCGAANK3 10q21.2 CHN2 7p14.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHN2
dbVarCHN2
ClinVarCHN2
1000_GenomesCHN2 
Exome Variant ServerCHN2
ExAC (Exome Aggregation Consortium)CHN2 (select the gene name)
Genetic variants : HAPMAP1124
Genomic Variants (DGV)CHN2 [DGVbeta]
DECIPHER (Syndromes)7:29519328-29553951  ENSG00000106069
CONAN: Copy Number AnalysisCHN2 
Mutations
ICGC Data PortalCHN2 
TCGA Data PortalCHN2 
Broad Tumor PortalCHN2
OASIS PortalCHN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHN2
DgiDB (Drug Gene Interaction Database)CHN2
DoCM (Curated mutations)CHN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHN2 (select a term)
intoGenCHN2
Cancer3DCHN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602857   
Orphanet
MedgenCHN2
Genetic Testing Registry CHN2
NextProtP52757 [Medical]
TSGene1124
GENETestsCHN2
Huge Navigator CHN2 [HugePedia]
snp3D : Map Gene to Disease1124
BioCentury BCIQCHN2
ClinGenCHN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1124
Chemical/Pharm GKB GenePA26474
Clinical trialCHN2
Miscellaneous
canSAR (ICR)CHN2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHN2
EVEXCHN2
GoPubMedCHN2
iHOPCHN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:56:29 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.