CHN2 (chimerin 2)

2006-10-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
ARHGAP3,BCH,CHN2-3,RHOGAP3
FUSION GENES

Other Information

Locus ID:

NCBI: 1124
MIM: 602857
HGNC: 1944
Ensembl: ENSG00000285162

Variants:

dbSNP: 1124
ClinVar: 1124
TCGA: ENSG00000285162
COSMIC: CHN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000285162ENST00000423511J3KSU2
ENSG00000285162ENST00000644824A0A2R8YEI5

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalMultilinkAnnotationassociated24444404

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158635132005Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.35
204604252010Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.22
163526602006Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells.15
197207902009Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.15
219117492011CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.15
182490952008Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.14
281605562017Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer.14
203351732010A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.13

Citation

Dessen P

CHN2 (chimerin 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43212/chn2