CHRD (chordin)

2007-02-01  

Identity

HGNC
CHRD
LOCATION
3q27.1
LOCUSID
8646
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8646
MIM: 603475
HGNC: 1949
Ensembl: ENSG00000090539

Variants:

dbSNP: 8646
ClinVar: 8646
TCGA: ENSG00000090539
COSMIC: CHRD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090539ENST00000204604Q9H2X0
ENSG00000090539ENST00000348986Q9H2X0
ENSG00000090539ENST00000356534Q9H2X0
ENSG00000090539ENST00000420973Q9H2X0
ENSG00000090539ENST00000448472Q9H2X0
ENSG00000090539ENST00000450923E7ESX1

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
185330302008Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells.27
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
190581742009Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion.19
251571652014Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding.15
164497962006Chordin is underexpressed in ovarian tumors and reduces tumor cell motility.14
190235702009Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
114728372001The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities.8
265178842015The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.5

Citation

Dessen P

CHRD (chordin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43607/chrd