CHRM1 (cholinergic receptor muscarinic 1)

2013-03-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
HM1,M1,M1R
FUSION GENES

Other Information

Locus ID:

NCBI: 1128
MIM: 118510
HGNC: 1950
Ensembl: ENSG00000168539

Variants:

dbSNP: 1128
ClinVar: 1128
TCGA: ENSG00000168539
COSMIC: CHRM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168539ENST00000306960P11229
ENSG00000168539ENST00000306960Q53XZ3
ENSG00000168539ENST00000536524F5GZF8
ENSG00000168539ENST00000543973P11229

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Regulation of actin cytoskeletonKEGGhsa04810
Cholinergic synapseKEGGhsa04725
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Muscarinic acetylcholine receptorsREACTOMER-HSA-390648
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201337362010Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.146
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
182723922008Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells.74
269588382016Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.70
187235152008A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.56
172727262007Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.52
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
124763232002Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia.45
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45

Citation

Dessen P

CHRM1 (cholinergic receptor muscarinic 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53220/chrm1