Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CHRM2 (cholinergic receptor muscarinic 2)

Identity

Alias_namesmuscarinic 2
Other aliasHM2
HGNC (Hugo) CHRM2
LocusID (NCBI) 1129
Atlas_Id 53984
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 136869085 and ends at 137017024 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHRM2 (7q33) / SLC20A2 (8p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRM2   1951
LRG (Locus Reference Genomic)LRG_405
Cards
Entrez_Gene (NCBI)CHRM2  1129  cholinergic receptor muscarinic 2
AliasesHM2
GeneCards (Weizmann)CHRM2
Ensembl hg19 (Hinxton)ENSG00000181072 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181072 [Gene_View]  ENSG00000181072 [Sequence]  chr7:136869085-137017024 [Contig_View]  CHRM2 [Vega]
ICGC DataPortalENSG00000181072
TCGA cBioPortalCHRM2
AceView (NCBI)CHRM2
Genatlas (Paris)CHRM2
WikiGenes1129
SOURCE (Princeton)CHRM2
Genetics Home Reference (NIH)CHRM2
Genomic and cartography
GoldenPath hg38 (UCSC)CHRM2  -     chr7:136869085-137017024 +  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRM2  -     7q33   [Description]    (hg19-Feb_2009)
EnsemblCHRM2 - 7q33 [CytoView hg19]  CHRM2 - 7q33 [CytoView hg38]
Mapping of homologs : NCBICHRM2 [Mapview hg19]  CHRM2 [Mapview hg38]
OMIM118493   
Gene and transcription
Genbank (Entrez)AF385588 AF498916 AK125233 AK290236 AL832585
RefSeq transcript (Entrez)NM_000739 NM_001006626 NM_001006627 NM_001006628 NM_001006629 NM_001006630 NM_001006631 NM_001006632 NM_001006633
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRM2
Cluster EST : UnigeneHs.535891 [ NCBI ]
CGAP (NCI)Hs.535891
Alternative Splicing GalleryENSG00000181072
Gene ExpressionCHRM2 [ NCBI-GEO ]   CHRM2 [ EBI - ARRAY_EXPRESS ]   CHRM2 [ SEEK ]   CHRM2 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1129
GTEX Portal (Tissue expression)CHRM2
Human Protein AtlasENSG00000181072-CHRM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08172
Splice isoforms : SwissVarP08172
PhosPhoSitePlusP08172
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Musac_Ach_M2_rcpt    Musac_Ach_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)CHRM2
DMDM Disease mutations1129
Blocks (Seattle)CHRM2
PDB (SRS)1LUB    3UON    4MQS    4MQT   
PDB (PDBSum)1LUB    3UON    4MQS    4MQT   
PDB (IMB)1LUB    3UON    4MQS    4MQT   
PDB (RSDB)1LUB    3UON    4MQS    4MQT   
Structural Biology KnowledgeBase1LUB    3UON    4MQS    4MQT   
SCOP (Structural Classification of Proteins)1LUB    3UON    4MQS    4MQT   
CATH (Classification of proteins structures)1LUB    3UON    4MQS    4MQT   
SuperfamilyP08172
Human Protein Atlas [tissue]ENSG00000181072-CHRM2 [tissue]
Peptide AtlasP08172
HPRD00328
IPIIPI00027473   
Protein Interaction databases
DIP (DOE-UCLA)P08172
IntAct (EBI)P08172
FunCoupENSG00000181072
BioGRIDCHRM2
STRING (EMBL)CHRM2
ZODIACCHRM2
Ontologies - Pathways
QuickGOP08172
Ontology : AmiGOG protein-coupled receptor activity  G protein-coupled serotonin receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  regulation of smooth muscle contraction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  G protein-coupled acetylcholine receptor signaling pathway  chemical synaptic transmission  nervous system development  regulation of heart contraction  drug binding  response to virus  integral component of membrane  G protein-coupled acetylcholine receptor activity  G protein-coupled acetylcholine receptor activity  cell junction  dendrite  neurotransmitter receptor activity  clathrin-coated vesicle membrane  asymmetric synapse  symmetric synapse  neuronal cell body  axon terminus  membrane organization  G protein-coupled serotonin receptor signaling pathway  glutamatergic synapse  cholinergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  arrestin family protein binding  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIG protein-coupled receptor activity  G protein-coupled serotonin receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  regulation of smooth muscle contraction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  G protein-coupled acetylcholine receptor signaling pathway  chemical synaptic transmission  nervous system development  regulation of heart contraction  drug binding  response to virus  integral component of membrane  G protein-coupled acetylcholine receptor activity  G protein-coupled acetylcholine receptor activity  cell junction  dendrite  neurotransmitter receptor activity  clathrin-coated vesicle membrane  asymmetric synapse  symmetric synapse  neuronal cell body  axon terminus  membrane organization  G protein-coupled serotonin receptor signaling pathway  glutamatergic synapse  cholinergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  arrestin family protein binding  regulation of synaptic vesicle exocytosis  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway    Cholinergic synapse    Regulation of actin cytoskeleton   
NDEx NetworkCHRM2
Atlas of Cancer Signalling NetworkCHRM2
Wikipedia pathwaysCHRM2
Orthology - Evolution
OrthoDB1129
GeneTree (enSembl)ENSG00000181072
Phylogenetic Trees/Animal Genes : TreeFamCHRM2
HOVERGENP08172
HOGENOMP08172
Homologs : HomoloGeneCHRM2
Homology/Alignments : Family Browser (UCSC)CHRM2
Gene fusions - Rearrangements
Fusion : QuiverCHRM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRM2
dbVarCHRM2
ClinVarCHRM2
1000_GenomesCHRM2 
Exome Variant ServerCHRM2
ExAC (Exome Aggregation Consortium)ENSG00000181072
GNOMAD BrowserENSG00000181072
Varsome BrowserCHRM2
Genetic variants : HAPMAP1129
Genomic Variants (DGV)CHRM2 [DGVbeta]
DECIPHERCHRM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRM2 
Mutations
ICGC Data PortalCHRM2 
TCGA Data PortalCHRM2 
Broad Tumor PortalCHRM2
OASIS PortalCHRM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRM2
DgiDB (Drug Gene Interaction Database)CHRM2
DoCM (Curated mutations)CHRM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRM2 (select a term)
intoGenCHRM2
Cancer3DCHRM2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118493   
Orphanet
DisGeNETCHRM2
MedgenCHRM2
Genetic Testing Registry CHRM2
NextProtP08172 [Medical]
TSGene1129
GENETestsCHRM2
Target ValidationCHRM2
Huge Navigator CHRM2 [HugePedia]
snp3D : Map Gene to Disease1129
BioCentury BCIQCHRM2
ClinGenCHRM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1129
Chemical/Pharm GKB GenePA111
Clinical trialCHRM2
Miscellaneous
canSAR (ICR)CHRM2 (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRM2
EVEXCHRM2
GoPubMedCHRM2
iHOPCHRM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:58:16 CET 2018

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