CHRM3 (cholinergic receptor muscarinic 3)

2008-12-01  

Identity

HGNC
LOCATION
1q43
LOCUSID
ALIAS
EGBRS,HM3,PBS
FUSION GENES

Other Information

Locus ID:

NCBI: 1131
MIM: 118494
HGNC: 1952
Ensembl: ENSG00000133019

Variants:

dbSNP: 1131
ClinVar: 1131
TCGA: ENSG00000133019
COSMIC: CHRM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133019ENST00000255380P20309
ENSG00000133019ENST00000255380A0A024R3S2
ENSG00000133019ENST00000448020B1AN12
ENSG00000133019ENST00000615928P20309
ENSG00000133019ENST00000615928A0A024R3S2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Regulation of actin cytoskeletonKEGGhsa04810
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Cholinergic synapseKEGGhsa04725
Insulin secretionKEGGhsa04911
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Muscarinic acetylcholine receptorsREACTOMER-HSA-390648
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Acetylcholine regulates insulin secretionREACTOMER-HSA-399997

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
182723922008Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells.74
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.48
195750102009The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.47
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
218739962011Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers.46
229495132012Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.42
163686942006Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization.39
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39

Citation

Dessen P

CHRM3 (cholinergic receptor muscarinic 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50505/chrm3