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CHRM4 (cholinergic receptor muscarinic 4)

Identity

Alias_namesmuscarinic 4
Other aliasHM4
M4R
HGNC (Hugo) CHRM4
LocusID (NCBI) 1132
Atlas_Id 56289
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46384792 and ends at 46386608 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRM4   1953
Cards
Entrez_Gene (NCBI)CHRM4  1132  cholinergic receptor muscarinic 4
AliasesHM4; M4R
GeneCards (Weizmann)CHRM4
Ensembl hg19 (Hinxton)ENSG00000180720 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180720 [Gene_View]  chr11:46384792-46386608 [Contig_View]  CHRM4 [Vega]
ICGC DataPortalENSG00000180720
TCGA cBioPortalCHRM4
AceView (NCBI)CHRM4
Genatlas (Paris)CHRM4
WikiGenes1132
SOURCE (Princeton)CHRM4
Genetics Home Reference (NIH)CHRM4
Genomic and cartography
GoldenPath hg38 (UCSC)CHRM4  -     chr11:46384792-46386608 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRM4  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblCHRM4 - 11p11.2 [CytoView hg19]  CHRM4 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBICHRM4 [Mapview hg19]  CHRM4 [Mapview hg38]
OMIM118495   
Gene and transcription
Genbank (Entrez)AF385590 AF498918 BC095546 BC119775 BC119817
RefSeq transcript (Entrez)NM_000741
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRM4
Cluster EST : UnigeneHs.248100 [ NCBI ]
CGAP (NCI)Hs.248100
Alternative Splicing GalleryENSG00000180720
Gene ExpressionCHRM4 [ NCBI-GEO ]   CHRM4 [ EBI - ARRAY_EXPRESS ]   CHRM4 [ SEEK ]   CHRM4 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1132
GTEX Portal (Tissue expression)CHRM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08173   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08173  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08173
Splice isoforms : SwissVarP08173
PhosPhoSitePlusP08173
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Musac_Ach_M4_rcpt    Musac_Ach_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)CHRM4
DMDM Disease mutations1132
Blocks (Seattle)CHRM4
PDB (SRS)5DSG   
PDB (PDBSum)5DSG   
PDB (IMB)5DSG   
PDB (RSDB)5DSG   
Structural Biology KnowledgeBase5DSG   
SCOP (Structural Classification of Proteins)5DSG   
CATH (Classification of proteins structures)5DSG   
SuperfamilyP08173
Human Protein AtlasENSG00000180720
Peptide AtlasP08173
HPRD00330
IPIIPI00027474   
Protein Interaction databases
DIP (DOE-UCLA)P08173
IntAct (EBI)P08173
FunCoupENSG00000180720
BioGRIDCHRM4
STRING (EMBL)CHRM4
ZODIACCHRM4
Ontologies - Pathways
QuickGOP08173
Ontology : AmiGOplasma membrane  integral component of plasma membrane  signal transduction  cell surface receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway  phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway  G-protein coupled acetylcholine receptor signaling pathway  synaptic transmission, cholinergic  cell proliferation  G-protein coupled acetylcholine receptor activity  cell junction  regulation of locomotion  synapse  postsynaptic membrane  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  signal transduction  cell surface receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway  phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway  G-protein coupled acetylcholine receptor signaling pathway  synaptic transmission, cholinergic  cell proliferation  G-protein coupled acetylcholine receptor activity  cell junction  regulation of locomotion  synapse  postsynaptic membrane  
Pathways : KEGGNeuroactive ligand-receptor interaction    Cholinergic synapse    Regulation of actin cytoskeleton   
NDEx NetworkCHRM4
Atlas of Cancer Signalling NetworkCHRM4
Wikipedia pathwaysCHRM4
Orthology - Evolution
OrthoDB1132
GeneTree (enSembl)ENSG00000180720
Phylogenetic Trees/Animal Genes : TreeFamCHRM4
HOVERGENP08173
HOGENOMP08173
Homologs : HomoloGeneCHRM4
Homology/Alignments : Family Browser (UCSC)CHRM4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRM4
dbVarCHRM4
ClinVarCHRM4
1000_GenomesCHRM4 
Exome Variant ServerCHRM4
ExAC (Exome Aggregation Consortium)CHRM4 (select the gene name)
Genetic variants : HAPMAP1132
Genomic Variants (DGV)CHRM4 [DGVbeta]
DECIPHERCHRM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRM4 
Mutations
ICGC Data PortalCHRM4 
TCGA Data PortalCHRM4 
Broad Tumor PortalCHRM4
OASIS PortalCHRM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRM4
DgiDB (Drug Gene Interaction Database)CHRM4
DoCM (Curated mutations)CHRM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRM4 (select a term)
intoGenCHRM4
Cancer3DCHRM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118495   
Orphanet
MedgenCHRM4
Genetic Testing Registry CHRM4
NextProtP08173 [Medical]
TSGene1132
GENETestsCHRM4
Target ValidationCHRM4
Huge Navigator CHRM4 [HugePedia]
snp3D : Map Gene to Disease1132
BioCentury BCIQCHRM4
ClinGenCHRM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1132
Chemical/Pharm GKB GenePA26485
Clinical trialCHRM4
Miscellaneous
canSAR (ICR)CHRM4 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRM4
EVEXCHRM4
GoPubMedCHRM4
iHOPCHRM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:22 CEST 2017

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