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CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit)

Identity

Alias_namesnicotinic
alpha 10 (neuronal)
Other alias-
HGNC (Hugo) CHRNA10
LocusID (NCBI) 57053
Atlas_Id 55949
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 3665587 and ends at 3671384 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNA10   13800
Cards
Entrez_Gene (NCBI)CHRNA10  57053  cholinergic receptor nicotinic alpha 10 subunit
Aliases
GeneCards (Weizmann)CHRNA10
Ensembl hg19 (Hinxton)ENSG00000129749 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129749 [Gene_View]  ENSG00000129749 [Sequence]  chr11:3665587-3671384 [Contig_View]  CHRNA10 [Vega]
ICGC DataPortalENSG00000129749
TCGA cBioPortalCHRNA10
AceView (NCBI)CHRNA10
Genatlas (Paris)CHRNA10
WikiGenes57053
SOURCE (Princeton)CHRNA10
Genetics Home Reference (NIH)CHRNA10
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNA10  -     chr11:3665587-3671384 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNA10  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathCHRNA10 - 11p15.4 [CytoView hg19]  CHRNA10 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000129749
Mapping of homologs : NCBICHRNA10 [Mapview hg19]  CHRNA10 [Mapview hg38]
OMIM606372   
Gene and transcription
Genbank (Entrez)AF199235 AJ278118 AJ295237 BC136250 BC143303
RefSeq transcript (Entrez)NM_001303034 NM_001303035 NM_020402
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRNA10
Cluster EST : UnigeneHs.732806 [ NCBI ]
CGAP (NCI)Hs.732806
Alternative Splicing GalleryENSG00000129749
Gene ExpressionCHRNA10 [ NCBI-GEO ]   CHRNA10 [ EBI - ARRAY_EXPRESS ]   CHRNA10 [ SEEK ]   CHRNA10 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57053
GTEX Portal (Tissue expression)CHRNA10
Human Protein AtlasENSG00000129749-CHRNA10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZZ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZZ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZZ6
Splice isoforms : SwissVarQ9GZZ6
PhosPhoSitePlusQ9GZZ6
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Neur_chan_lig-bd    Neur_chan_lig-bd_sf    Neur_channel    Neuro-gated_channel_TM_sf    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA10
DMDM Disease mutations57053
Blocks (Seattle)CHRNA10
SuperfamilyQ9GZZ6
Human Protein Atlas [tissue]ENSG00000129749-CHRNA10 [tissue]
Peptide AtlasQ9GZZ6
HPRD09395
IPIIPI00026461   IPI00984153   IPI00985054   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZZ6
IntAct (EBI)Q9GZZ6
FunCoupENSG00000129749
BioGRIDCHRNA10
STRING (EMBL)CHRNA10
ZODIACCHRNA10
Ontologies - Pathways
QuickGOQ9GZZ6
Ontology : AmiGOtransmembrane signaling receptor activity  signaling receptor binding  extracellular ligand-gated ion channel activity  calcium channel activity  integral component of plasma membrane  signal transduction  positive regulation of cytosolic calcium ion concentration  chemical synaptic transmission  synaptic transmission, cholinergic  membrane  acetylcholine-gated cation-selective channel activity  cell junction  axon  ion transmembrane transport  regulation of cell proliferation  regulation of membrane potential  inner ear morphogenesis  neuron projection  perikaryon  synapse  nervous system process  detection of mechanical stimulus involved in sensory perception of sound  excitatory postsynaptic potential  negative regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  cholinergic synapse  integral component of postsynaptic specialization membrane  
Ontology : EGO-EBItransmembrane signaling receptor activity  signaling receptor binding  extracellular ligand-gated ion channel activity  calcium channel activity  integral component of plasma membrane  signal transduction  positive regulation of cytosolic calcium ion concentration  chemical synaptic transmission  synaptic transmission, cholinergic  membrane  acetylcholine-gated cation-selective channel activity  cell junction  axon  ion transmembrane transport  regulation of cell proliferation  regulation of membrane potential  inner ear morphogenesis  neuron projection  perikaryon  synapse  nervous system process  detection of mechanical stimulus involved in sensory perception of sound  excitatory postsynaptic potential  negative regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  cholinergic synapse  integral component of postsynaptic specialization membrane  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkCHRNA10
Atlas of Cancer Signalling NetworkCHRNA10
Wikipedia pathwaysCHRNA10
Orthology - Evolution
OrthoDB57053
GeneTree (enSembl)ENSG00000129749
Phylogenetic Trees/Animal Genes : TreeFamCHRNA10
HOGENOMQ9GZZ6
Homologs : HomoloGeneCHRNA10
Homology/Alignments : Family Browser (UCSC)CHRNA10
Gene fusions - Rearrangements
Fusion : QuiverCHRNA10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA10
dbVarCHRNA10
ClinVarCHRNA10
1000_GenomesCHRNA10 
Exome Variant ServerCHRNA10
ExAC (Exome Aggregation Consortium)ENSG00000129749
GNOMAD BrowserENSG00000129749
Varsome BrowserCHRNA10
Genetic variants : HAPMAP57053
Genomic Variants (DGV)CHRNA10 [DGVbeta]
DECIPHERCHRNA10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNA10 
Mutations
ICGC Data PortalCHRNA10 
TCGA Data PortalCHRNA10 
Broad Tumor PortalCHRNA10
OASIS PortalCHRNA10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA10
DgiDB (Drug Gene Interaction Database)CHRNA10
DoCM (Curated mutations)CHRNA10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA10 (select a term)
intoGenCHRNA10
Cancer3DCHRNA10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606372   
Orphanet
DisGeNETCHRNA10
MedgenCHRNA10
Genetic Testing Registry CHRNA10
NextProtQ9GZZ6 [Medical]
TSGene57053
GENETestsCHRNA10
Target ValidationCHRNA10
Huge Navigator CHRNA10 [HugePedia]
snp3D : Map Gene to Disease57053
BioCentury BCIQCHRNA10
ClinGenCHRNA10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57053
Chemical/Pharm GKB GenePA26488
Clinical trialCHRNA10
Miscellaneous
canSAR (ICR)CHRNA10 (select the gene name)
DataMed IndexCHRNA10
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA10
EVEXCHRNA10
GoPubMedCHRNA10
iHOPCHRNA10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 8 11:14:59 CEST 2019

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