CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit)

2016-10-01  

Identity

HGNC
CHRNA10
LOCATION
11p15.4
LOCUSID
57053
ALIAS
-

Other Information

Locus ID:

NCBI: 57053
MIM: 606372
HGNC: 13800
Ensembl: ENSG00000129749

Variants:

dbSNP: 57053
ClinVar: 57053
TCGA: ENSG00000129749
COSMIC: CHRNA10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129749ENST00000250699Q9GZZ6
ENSG00000129749ENST00000526599E9PNT7
ENSG00000129749ENST00000534359E9PNX2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080

References

Pubmed IDYearTitleCitations
192599742009Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.121
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205842122010Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.58
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
227748722012Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.35
197606732010Association of CHRN genes with "dizziness" to tobacco.27
175594192008Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.21
173736922007No evidence for association between 19 cholinergic genes and bipolar disorder.10
202318572011Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.5

Citation

Dessen P

CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55949/chrna10