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CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)

Identity

Alias_namescholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic alpha 2
Other alias-
HGNC (Hugo) CHRNA2
LocusID (NCBI) 1135
Atlas_Id 61815
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 27459761 and ends at 27479296 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHRNA2 (8p21.2) / CAPN3 (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

1135
Nomenclature
HGNC (Hugo)CHRNA2   1956
Cards
Entrez_Gene (NCBI)CHRNA2  1135  cholinergic receptor nicotinic alpha 2 subunit
Aliases
GeneCards (Weizmann)CHRNA2
Ensembl hg19 (Hinxton)ENSG00000120903 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120903 [Gene_View]  chr8:27459761-27479296 [Contig_View]  CHRNA2 [Vega]
ICGC DataPortalENSG00000120903
TCGA cBioPortalCHRNA2
AceView (NCBI)CHRNA2
Genatlas (Paris)CHRNA2
WikiGenes1135
SOURCE (Princeton)CHRNA2
Genetics Home Reference (NIH)CHRNA2
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNA2  -     chr8:27459761-27479296 -  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNA2  -     8p21.2   [Description]    (hg19-Feb_2009)
EnsemblCHRNA2 - 8p21.2 [CytoView hg19]  CHRNA2 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBICHRNA2 [Mapview hg19]  CHRNA2 [Mapview hg38]
OMIM118502   610353   
Gene and transcription
Genbank (Entrez)AK296348 AK308465 AK314787 AW292180 BC153866
RefSeq transcript (Entrez)NM_000742 NM_001282455 NM_001347705 NM_001347706 NM_001347707 NM_001347708
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRNA2
Cluster EST : UnigeneHs.57718 [ NCBI ]
CGAP (NCI)Hs.57718
Alternative Splicing GalleryENSG00000120903
Gene ExpressionCHRNA2 [ NCBI-GEO ]   CHRNA2 [ EBI - ARRAY_EXPRESS ]   CHRNA2 [ SEEK ]   CHRNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)
GTEX Portal (Tissue expression)CHRNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15822   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15822  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15822
Splice isoforms : SwissVarQ15822
PhosPhoSitePlusQ15822
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA2
DMDM Disease mutations1135
Blocks (Seattle)CHRNA2
PDB (SRS)5FJV   
PDB (PDBSum)5FJV   
PDB (IMB)5FJV   
PDB (RSDB)5FJV   
Structural Biology KnowledgeBase5FJV   
SCOP (Structural Classification of Proteins)5FJV   
CATH (Classification of proteins structures)5FJV   
SuperfamilyQ15822
Human Protein AtlasENSG00000120903
Peptide AtlasQ15822
HPRD00332
IPIIPI00019942   IPI00978055   IPI00972998   IPI00982268   IPI00978837   IPI00979303   IPI00984274   
Protein Interaction databases
DIP (DOE-UCLA)Q15822
IntAct (EBI)Q15822
FunCoupENSG00000120903
BioGRIDCHRNA2
STRING (EMBL)CHRNA2
ZODIACCHRNA2
Ontologies - Pathways
QuickGOQ15822
Ontology : AmiGOplasma membrane  acetylcholine-gated channel complex  ion transport  signal transduction  synaptic transmission, cholinergic  neuromuscular synaptic transmission  drug binding  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  acetylcholine binding  postsynaptic membrane  protein heterooligomerization  excitatory postsynaptic potential  cation transmembrane transport  
Ontology : EGO-EBIplasma membrane  acetylcholine-gated channel complex  ion transport  signal transduction  synaptic transmission, cholinergic  neuromuscular synaptic transmission  drug binding  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  acetylcholine binding  postsynaptic membrane  protein heterooligomerization  excitatory postsynaptic potential  cation transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkCHRNA2
Atlas of Cancer Signalling NetworkCHRNA2
Wikipedia pathwaysCHRNA2
Orthology - Evolution
OrthoDB1135
GeneTree (enSembl)ENSG00000120903
Phylogenetic Trees/Animal Genes : TreeFamCHRNA2
HOVERGENQ15822
HOGENOMQ15822
Homologs : HomoloGeneCHRNA2
Homology/Alignments : Family Browser (UCSC)CHRNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA2
dbVarCHRNA2
ClinVarCHRNA2
1000_GenomesCHRNA2 
Exome Variant ServerCHRNA2
ExAC (Exome Aggregation Consortium)CHRNA2 (select the gene name)
Genetic variants : HAPMAP1135
Genomic Variants (DGV)CHRNA2 [DGVbeta]
DECIPHERCHRNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNA2 
Mutations
ICGC Data PortalCHRNA2 
TCGA Data PortalCHRNA2 
Broad Tumor PortalCHRNA2
OASIS PortalCHRNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA2
DgiDB (Drug Gene Interaction Database)CHRNA2
DoCM (Curated mutations)CHRNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA2 (select a term)
intoGenCHRNA2
Cancer3DCHRNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118502    610353   
Orphanet13801   
MedgenCHRNA2
Genetic Testing Registry CHRNA2
NextProtQ15822 [Medical]
TSGene1135
GENETestsCHRNA2
Target ValidationCHRNA2
Huge Navigator CHRNA2 [HugePedia]
snp3D : Map Gene to Disease1135
BioCentury BCIQCHRNA2
ClinGenCHRNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1135
Chemical/Pharm GKB GenePA26489
Clinical trialCHRNA2
Miscellaneous
canSAR (ICR)CHRNA2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA2
EVEXCHRNA2
GoPubMedCHRNA2
iHOPCHRNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:04:48 CEST 2017

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