Identity
HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
BAIPRCK,LNCR2,NACHRA3,PAOD2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1136
MIM: 118503
HGNC: 1957
Ensembl: ENSG00000080644
Variants:
dbSNP: 1136
ClinVar: 1136
TCGA: ENSG00000080644
COSMIC: CHRNA3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000080644 | ENST00000326828 | P32297 |
| ENSG00000080644 | ENST00000348639 | P32297 |
| ENSG00000080644 | ENST00000559080 | H0YNF9 |
| ENSG00000080644 | ENST00000559658 | P32297 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712720 | Drugs used in nicotine dependence | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164712950 | Opium alkaloids and derivatives | Chemical | ClinicalAnnotation | associated | PD | 20725741 | |
| PA166048714 | Pregnancy | Disease | ClinicalAnnotation | associated | |||
| PA166114414 | cotinine | Chemical | ClinicalAnnotation | associated | PK | ||
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | ||
| PA445208 | Pain | Disease | ClinicalAnnotation | associated | PD | 20725741 | |
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PK | PD | 20886544 |
| PA446878 | Cocaine-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 32152934 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449072 | cocaine | Chemical | ClinicalAnnotation | associated | PD | 32152934 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PK | PD | 20886544, 24535486, 31402126 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36078193 | 2022 | Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine. | 3 |
| 36078193 | 2022 | Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine. | 3 |
| 33578531 | 2021 | The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review. | 3 |
| 33583893 | 2021 | Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies. | 1 |
| 33947782 | 2021 | Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. | 4 |
| 33578531 | 2021 | The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review. | 3 |
| 33583893 | 2021 | Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies. | 1 |
| 33947782 | 2021 | Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. | 4 |
| 31402126 | 2020 | Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer. | 4 |
| 32980672 | 2020 | Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis. | 7 |
| 31402126 | 2020 | Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer. | 4 |
| 32980672 | 2020 | Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis. | 7 |
| 31362771 | 2019 | CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study. | 4 |
| 31588985 | 2019 | [Analysis of polymorphism rs1051730 of CHRNA3 in patients with dual pathology in a Mexican population]. | 0 |
| 31599127 | 2019 | Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population. | 5 |
Citation
Dessen P
CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/50155/chrna3
