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CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)

Identity

Alias_namesnicotinic
alpha 3 (neuronal)
Other aliasLNCR2
NACHRA3
PAOD2
HGNC (Hugo) CHRNA3
LocusID (NCBI) 1136
Atlas_Id 50155
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78593053 and ends at 78621295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHRNA3 (15q25.1) / CHRNA3 (15q25.1)TPGS1 (19p13.3) / CHRNA3 (15q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNA3   1957
Cards
Entrez_Gene (NCBI)CHRNA3  1136  cholinergic receptor nicotinic alpha 3 subunit
AliasesLNCR2; NACHRA3; PAOD2
GeneCards (Weizmann)CHRNA3
Ensembl hg19 (Hinxton)ENSG00000080644 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080644 [Gene_View]  ENSG00000080644 [Sequence]  chr15:78593053-78621295 [Contig_View]  CHRNA3 [Vega]
ICGC DataPortalENSG00000080644
TCGA cBioPortalCHRNA3
AceView (NCBI)CHRNA3
Genatlas (Paris)CHRNA3
WikiGenes1136
SOURCE (Princeton)CHRNA3
Genetics Home Reference (NIH)CHRNA3
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNA3  -     chr15:78593053-78621295 -  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNA3  -     15q25.1   [Description]    (hg19-Feb_2009)
EnsemblCHRNA3 - 15q25.1 [CytoView hg19]  CHRNA3 - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBICHRNA3 [Mapview hg19]  CHRNA3 [Mapview hg38]
OMIM118503   612052   
Gene and transcription
Genbank (Entrez)AF385584 AI833126 AJ584707 AJ584708 AJ584709
RefSeq transcript (Entrez)NM_000743 NM_001166694
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRNA3
Cluster EST : UnigeneHs.89605 [ NCBI ]
CGAP (NCI)Hs.89605
Alternative Splicing GalleryENSG00000080644
Gene ExpressionCHRNA3 [ NCBI-GEO ]   CHRNA3 [ EBI - ARRAY_EXPRESS ]   CHRNA3 [ SEEK ]   CHRNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1136
GTEX Portal (Tissue expression)CHRNA3
Human Protein AtlasENSG00000080644-CHRNA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32297   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32297  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32297
Splice isoforms : SwissVarP32297
PhosPhoSitePlusP32297
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA3
DMDM Disease mutations1136
Blocks (Seattle)CHRNA3
PDB (SRS)4ZK4    5SYO    5TVC   
PDB (PDBSum)4ZK4    5SYO    5TVC   
PDB (IMB)4ZK4    5SYO    5TVC   
PDB (RSDB)4ZK4    5SYO    5TVC   
Structural Biology KnowledgeBase4ZK4    5SYO    5TVC   
SCOP (Structural Classification of Proteins)4ZK4    5SYO    5TVC   
CATH (Classification of proteins structures)4ZK4    5SYO    5TVC   
SuperfamilyP32297
Human Protein Atlas [tissue]ENSG00000080644-CHRNA3 [tissue]
Peptide AtlasP32297
HPRD07511
IPIIPI00297165   IPI00852613   IPI00939562   IPI00956093   
Protein Interaction databases
DIP (DOE-UCLA)P32297
IntAct (EBI)P32297
FunCoupENSG00000080644
BioGRIDCHRNA3
STRING (EMBL)CHRNA3
ZODIACCHRNA3
Ontologies - Pathways
QuickGOP32297
Ontology : AmiGOprotein binding  plasma membrane  acetylcholine-gated channel complex  ion transport  regulation of smooth muscle contraction  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  synaptic transmission, cholinergic  nervous system development  locomotory behavior  regulation of acetylcholine secretion, neurotransmission  postsynaptic density  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  serotonin-gated cation-selective channel activity  cell junction  dendrite  behavioral response to nicotine  acetylcholine binding  regulation of membrane potential  neuronal cell body  plasma membrane raft  postsynaptic membrane  regulation of dendrite morphogenesis  excitatory postsynaptic potential  synaptic transmission involved in micturition  acetylcholine receptor signaling pathway  cation transmembrane transport  response to acetylcholine  
Ontology : EGO-EBIprotein binding  plasma membrane  acetylcholine-gated channel complex  ion transport  regulation of smooth muscle contraction  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  synaptic transmission, cholinergic  nervous system development  locomotory behavior  regulation of acetylcholine secretion, neurotransmission  postsynaptic density  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  serotonin-gated cation-selective channel activity  cell junction  dendrite  behavioral response to nicotine  acetylcholine binding  regulation of membrane potential  neuronal cell body  plasma membrane raft  postsynaptic membrane  regulation of dendrite morphogenesis  excitatory postsynaptic potential  synaptic transmission involved in micturition  acetylcholine receptor signaling pathway  cation transmembrane transport  response to acetylcholine  
NDEx NetworkCHRNA3
Atlas of Cancer Signalling NetworkCHRNA3
Wikipedia pathwaysCHRNA3
Orthology - Evolution
OrthoDB1136
GeneTree (enSembl)ENSG00000080644
Phylogenetic Trees/Animal Genes : TreeFamCHRNA3
HOVERGENP32297
HOGENOMP32297
Homologs : HomoloGeneCHRNA3
Homology/Alignments : Family Browser (UCSC)CHRNA3
Gene fusions - Rearrangements
Fusion : QuiverCHRNA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA3
dbVarCHRNA3
ClinVarCHRNA3
1000_GenomesCHRNA3 
Exome Variant ServerCHRNA3
ExAC (Exome Aggregation Consortium)ENSG00000080644
GNOMAD BrowserENSG00000080644
Genetic variants : HAPMAP1136
Genomic Variants (DGV)CHRNA3 [DGVbeta]
DECIPHERCHRNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNA3 
Mutations
ICGC Data PortalCHRNA3 
TCGA Data PortalCHRNA3 
Broad Tumor PortalCHRNA3
OASIS PortalCHRNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA3
DgiDB (Drug Gene Interaction Database)CHRNA3
DoCM (Curated mutations)CHRNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA3 (select a term)
intoGenCHRNA3
Cancer3DCHRNA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118503    612052   
Orphanet
DisGeNETCHRNA3
MedgenCHRNA3
Genetic Testing Registry CHRNA3
NextProtP32297 [Medical]
TSGene1136
GENETestsCHRNA3
Target ValidationCHRNA3
Huge Navigator CHRNA3 [HugePedia]
snp3D : Map Gene to Disease1136
BioCentury BCIQCHRNA3
ClinGenCHRNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1136
Chemical/Pharm GKB GenePA113
Clinical trialCHRNA3
Miscellaneous
canSAR (ICR)CHRNA3 (select the gene name)
Probes
Litterature
PubMed207 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA3
EVEXCHRNA3
GoPubMedCHRNA3
iHOPCHRNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:19:28 CEST 2018

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