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CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)

Identity

Alias_namesnicotinic
alpha 4 (neuronal)
Alias_symbol (synonym)BFNC
Other aliasEBN
EBN1
NACHR
NACHRA4
NACRA4
HGNC (Hugo) CHRNA4
LocusID (NCBI) 1137
Atlas_Id 46560
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 61974662 and ends at 61992748 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRKCB (16p12.2) / CHRNA4 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNA4   1958
Cards
Entrez_Gene (NCBI)CHRNA4  1137  cholinergic receptor nicotinic alpha 4 subunit
AliasesBFNC; EBN; EBN1; NACHR; 
NACHRA4; NACRA4
GeneCards (Weizmann)CHRNA4
Ensembl hg19 (Hinxton)ENSG00000101204 [Gene_View]  chr20:61974662-61992748 [Contig_View]  CHRNA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101204 [Gene_View]  chr20:61974662-61992748 [Contig_View]  CHRNA4 [Vega]
ICGC DataPortalENSG00000101204
TCGA cBioPortalCHRNA4
AceView (NCBI)CHRNA4
Genatlas (Paris)CHRNA4
WikiGenes1137
SOURCE (Princeton)CHRNA4
Genetics Home Reference (NIH)CHRNA4
Genomic and cartography
GoldenPath hg19 (UCSC)CHRNA4  -     chr20:61974662-61992748 -  20q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CHRNA4  -     20q13.33   [Description]    (hg38-Dec_2013)
EnsemblCHRNA4 - 20q13.33 [CytoView hg19]  CHRNA4 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBICHRNA4 [Mapview hg19]  CHRNA4 [Mapview hg38]
OMIM118504   188890   600513   
Gene and transcription
Genbank (Entrez)AK296430 AK314907 BC096290 BC096291 BC096292
RefSeq transcript (Entrez)NM_000744 NM_001256573
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_011931 NT_011362 NW_004929419
Consensus coding sequences : CCDS (NCBI)CHRNA4
Cluster EST : UnigeneHs.10734 [ NCBI ]
CGAP (NCI)Hs.10734
Alternative Splicing GalleryENSG00000101204
Gene ExpressionCHRNA4 [ NCBI-GEO ]   CHRNA4 [ EBI - ARRAY_EXPRESS ]   CHRNA4 [ SEEK ]   CHRNA4 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1137
GTEX Portal (Tissue expression)CHRNA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43681   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43681  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43681
Splice isoforms : SwissVarP43681
PhosPhoSitePlusP43681
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA4
DMDM Disease mutations1137
Blocks (Seattle)CHRNA4
PDB (SRS)2GVT    2LLY   
PDB (PDBSum)2GVT    2LLY   
PDB (IMB)2GVT    2LLY   
PDB (RSDB)2GVT    2LLY   
Structural Biology KnowledgeBase2GVT    2LLY   
SCOP (Structural Classification of Proteins)2GVT    2LLY   
CATH (Classification of proteins structures)2GVT    2LLY   
SuperfamilyP43681
Human Protein AtlasENSG00000101204
Peptide AtlasP43681
HPRD00333
IPIIPI00020036   IPI01014697   IPI00607706   IPI00983257   
Protein Interaction databases
DIP (DOE-UCLA)P43681
IntAct (EBI)P43681
FunCoupENSG00000101204
BioGRIDCHRNA4
STRING (EMBL)CHRNA4
ZODIACCHRNA4
Ontologies - Pathways
QuickGOP43681
Ontology : AmiGOaction potential  response to hypoxia  acetylcholine-activated cation-selective channel activity  acetylcholine-activated cation-selective channel activity  plasma membrane  plasma membrane  acetylcholine-gated channel complex  DNA repair  ion transport  calcium ion transport  response to oxidative stress  signal transduction  synaptic transmission  synaptic transmission, cholinergic  synaptic transmission, cholinergic  neuromuscular synaptic transmission  respiratory gaseous exchange  locomotory behavior  external side of plasma membrane  regulation of dopamine secretion  ligand-gated ion channel activity  acetylcholine receptor activity  membrane  integral component of membrane  sensory perception of pain  cell junction  dendrite  ion transmembrane transport  response to nicotine  behavioral response to nicotine  exploration behavior  B cell activation  acetylcholine binding  acetylcholine binding  regulation of membrane potential  neuronal cell body  postsynaptic membrane  neurological system process  cognition  membrane depolarization  inhibitory postsynaptic potential  cation transmembrane transport  cation transmembrane transport  cation transmembrane transport  
Ontology : EGO-EBIaction potential  response to hypoxia  acetylcholine-activated cation-selective channel activity  acetylcholine-activated cation-selective channel activity  plasma membrane  plasma membrane  acetylcholine-gated channel complex  DNA repair  ion transport  calcium ion transport  response to oxidative stress  signal transduction  synaptic transmission  synaptic transmission, cholinergic  synaptic transmission, cholinergic  neuromuscular synaptic transmission  respiratory gaseous exchange  locomotory behavior  external side of plasma membrane  regulation of dopamine secretion  ligand-gated ion channel activity  acetylcholine receptor activity  membrane  integral component of membrane  sensory perception of pain  cell junction  dendrite  ion transmembrane transport  response to nicotine  behavioral response to nicotine  exploration behavior  B cell activation  acetylcholine binding  acetylcholine binding  regulation of membrane potential  neuronal cell body  postsynaptic membrane  neurological system process  cognition  membrane depolarization  inhibitory postsynaptic potential  cation transmembrane transport  cation transmembrane transport  cation transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Cholinergic synapse    Nicotine addiction   
NDEx NetworkCHRNA4
Atlas of Cancer Signalling NetworkCHRNA4
Wikipedia pathwaysCHRNA4
Orthology - Evolution
OrthoDB1137
GeneTree (enSembl)ENSG00000101204
Phylogenetic Trees/Animal Genes : TreeFamCHRNA4
HOVERGENP43681
HOGENOMP43681
Homologs : HomoloGeneCHRNA4
Homology/Alignments : Family Browser (UCSC)CHRNA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA4
dbVarCHRNA4
ClinVarCHRNA4
1000_GenomesCHRNA4 
Exome Variant ServerCHRNA4
ExAC (Exome Aggregation Consortium)CHRNA4 (select the gene name)
Genetic variants : HAPMAP1137
Genomic Variants (DGV)CHRNA4 [DGVbeta]
DECIPHER (Syndromes)20:61974662-61992748  ENSG00000101204
CONAN: Copy Number AnalysisCHRNA4 
Mutations
ICGC Data PortalCHRNA4 
TCGA Data PortalCHRNA4 
Broad Tumor PortalCHRNA4
OASIS PortalCHRNA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA4
DgiDB (Drug Gene Interaction Database)CHRNA4
DoCM (Curated mutations)CHRNA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA4 (select a term)
intoGenCHRNA4
Cancer3DCHRNA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118504    188890    600513   
Orphanet13801   
MedgenCHRNA4
Genetic Testing Registry CHRNA4
NextProtP43681 [Medical]
TSGene1137
GENETestsCHRNA4
Huge Navigator CHRNA4 [HugePedia]
snp3D : Map Gene to Disease1137
BioCentury BCIQCHRNA4
ClinGenCHRNA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1137
Chemical/Pharm GKB GenePA26490
Clinical trialCHRNA4
Miscellaneous
canSAR (ICR)CHRNA4 (select the gene name)
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA4
EVEXCHRNA4
GoPubMedCHRNA4
iHOPCHRNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:00:29 CET 2017

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