Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)

Identity

Alias_namesnicotinic
alpha 6 (neuronal)
Other aliasCHNRA6
HGNC (Hugo) CHRNA6
LocusID (NCBI) 8973
Atlas_Id 52436
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 42752636 and ends at 42768786 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNA6   15963
Cards
Entrez_Gene (NCBI)CHRNA6  8973  cholinergic receptor nicotinic alpha 6 subunit
AliasesCHNRA6
GeneCards (Weizmann)CHRNA6
Ensembl hg19 (Hinxton)ENSG00000147434 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147434 [Gene_View]  chr8:42752636-42768786 [Contig_View]  CHRNA6 [Vega]
ICGC DataPortalENSG00000147434
TCGA cBioPortalCHRNA6
AceView (NCBI)CHRNA6
Genatlas (Paris)CHRNA6
WikiGenes8973
SOURCE (Princeton)CHRNA6
Genetics Home Reference (NIH)CHRNA6
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNA6  -     chr8:42752636-42768786 -  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNA6  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblCHRNA6 - 8p11.21 [CytoView hg19]  CHRNA6 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBICHRNA6 [Mapview hg19]  CHRNA6 [Mapview hg38]
OMIM606888   
Gene and transcription
Genbank (Entrez)AK298798 AK313521 BC014456 DC307404 HQ448331
RefSeq transcript (Entrez)NM_001199279 NM_004198
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRNA6
Cluster EST : UnigeneHs.103128 [ NCBI ]
CGAP (NCI)Hs.103128
Alternative Splicing GalleryENSG00000147434
Gene ExpressionCHRNA6 [ NCBI-GEO ]   CHRNA6 [ EBI - ARRAY_EXPRESS ]   CHRNA6 [ SEEK ]   CHRNA6 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8973
GTEX Portal (Tissue expression)CHRNA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15825   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15825  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15825
Splice isoforms : SwissVarQ15825
PhosPhoSitePlusQ15825
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA6
DMDM Disease mutations8973
Blocks (Seattle)CHRNA6
SuperfamilyQ15825
Human Protein AtlasENSG00000147434
Peptide AtlasQ15825
HPRD06056
IPIIPI00019948   IPI00981699   IPI00981021   
Protein Interaction databases
DIP (DOE-UCLA)Q15825
IntAct (EBI)Q15825
FunCoupENSG00000147434
BioGRIDCHRNA6
STRING (EMBL)CHRNA6
ZODIACCHRNA6
Ontologies - Pathways
QuickGOQ15825
Ontology : AmiGOprotein binding  plasma membrane  acetylcholine-gated channel complex  transport  signal transduction  chemical synaptic transmission  synaptic transmission, cholinergic  neuromuscular synaptic transmission  regulation of dopamine secretion  ligand-gated ion channel activity  acetylcholine receptor activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  acetylcholine binding  postsynaptic membrane  membrane depolarization  excitatory postsynaptic potential  cation transmembrane transport  
Ontology : EGO-EBIprotein binding  plasma membrane  acetylcholine-gated channel complex  transport  signal transduction  chemical synaptic transmission  synaptic transmission, cholinergic  neuromuscular synaptic transmission  regulation of dopamine secretion  ligand-gated ion channel activity  acetylcholine receptor activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  acetylcholine binding  postsynaptic membrane  membrane depolarization  excitatory postsynaptic potential  cation transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Cholinergic synapse    Nicotine addiction   
NDEx NetworkCHRNA6
Atlas of Cancer Signalling NetworkCHRNA6
Wikipedia pathwaysCHRNA6
Orthology - Evolution
OrthoDB8973
GeneTree (enSembl)ENSG00000147434
Phylogenetic Trees/Animal Genes : TreeFamCHRNA6
HOVERGENQ15825
HOGENOMQ15825
Homologs : HomoloGeneCHRNA6
Homology/Alignments : Family Browser (UCSC)CHRNA6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA6
dbVarCHRNA6
ClinVarCHRNA6
1000_GenomesCHRNA6 
Exome Variant ServerCHRNA6
ExAC (Exome Aggregation Consortium)CHRNA6 (select the gene name)
Genetic variants : HAPMAP8973
Genomic Variants (DGV)CHRNA6 [DGVbeta]
DECIPHERCHRNA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNA6 
Mutations
ICGC Data PortalCHRNA6 
TCGA Data PortalCHRNA6 
Broad Tumor PortalCHRNA6
OASIS PortalCHRNA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA6
DgiDB (Drug Gene Interaction Database)CHRNA6
DoCM (Curated mutations)CHRNA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA6 (select a term)
intoGenCHRNA6
Cancer3DCHRNA6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606888   
Orphanet
MedgenCHRNA6
Genetic Testing Registry CHRNA6
NextProtQ15825 [Medical]
TSGene8973
GENETestsCHRNA6
Target ValidationCHRNA6
Huge Navigator CHRNA6 [HugePedia]
snp3D : Map Gene to Disease8973
BioCentury BCIQCHRNA6
ClinGenCHRNA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8973
Chemical/Pharm GKB GenePA26492
Clinical trialCHRNA6
Miscellaneous
canSAR (ICR)CHRNA6 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA6
EVEXCHRNA6
GoPubMedCHRNA6
iHOPCHRNA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:24 CEST 2017

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