CHRNA7 (cholinergic receptor, nicotinic, alpha 7)

Identity

Other names	CHRNA7-2
	NACHRA7
HGNC	CHRNA7
Location	15q13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CHRNA7   1960
Entrez_Gene	CHRNA7  1139  cholinergic receptor, nicotinic, alpha 7
	Cards
GeneCards	CHRNA7
Ensembl	CHRNA7 [Search_View]   ENSG00000175344 [Gene_View]
Genatlas	CHRNA7
GeneLynx	CHRNA7
eGenome	CHRNA7
euGene	1139
	Genomic and cartography
GoldenPath	CHRNA7  -  15q13.3   chr15:30110018-30248527 +  15q13.3   [Description]    (hg18-March_2006)
Ensembl	CHRNA7 - 15q13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CHRNA7
	Gene and transcription
Genbank	AF385585 [ ENTREZ ]
Genbank	AJ586911 [ ENTREZ ]
Genbank	AK292069 [ ENTREZ ]
Genbank	AK294229 [ ENTREZ ]
Genbank	AK309709 [ ENTREZ ]
RefSeq	NM_000746 [ SRS ]    NM_000746 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	AC_000147 [ SRS ]    AC_000147 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_001838206 [ SRS ]    NW_001838206 [ ENTREZ ]
RefSeq	NW_925818 [ SRS ]    NW_925818 [ ENTREZ ]
AceView	CHRNA7 AceView - NCBI
Unigene	Hs.511772 [ SRS ]    Hs.511772 [ NCBI ]     HS511772 [ spliceNest ]
Fast-db	1126 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P36544 [ SRS]    P36544 [ EXPASY ]     P36544 [ INTERPRO ]     P36544 [ UNIPROT ]
Prosite	PS00236 NEUROTR_ION_CHANNEL [ SRS ]    PS00236 NEUROTR_ION_CHANNEL [ Expasy ]
Interpro	IPR006029 Neu_channel_TM [ SRS ]    IPR006029 Neu_channel_TM [ EBI ]
Interpro	IPR006202 Neur_chan_lig_bd [ SRS ]    IPR006202 Neur_chan_lig_bd [ EBI ]
Interpro	IPR006201 Neur_channel [ SRS ]    IPR006201 Neur_channel [ EBI ]
Interpro	IPR002394 Nicotinic_acetylcholine_rcpt_N [ SRS ]    IPR002394 Nicotinic_acetylcholine_rcpt_N [ EBI ]
CluSTr	P36544
Pfam	PF02931 Neur_chan_LBD [ SRS ]    PF02931 Neur_chan_LBD [ Sanger ]    pfam02931 [ NCBI-CDD ]
Pfam	PF02932 Neur_chan_memb [ SRS ]    PF02932 Neur_chan_memb [ Sanger ]    pfam02932 [ NCBI-CDD ]
Blocks	P36544
HPRD	00339
	Protein Interaction databases
DIP	P36544
IntAct	P36544
	Polymorphism : SNP, mutations, diseases
OMIM	118511    [ map ]
GENECLINICS	118511
SNP	CHRNA7 [dbSNP-NCBI]
SNP	NM_000746 [SNP-NCI]
SNP	CHRNA7 [GeneSNPs - Utah]  CHRNA7] [HGBASE - SRS]
HAPMAP	CHRNA7 [HAPMAP]
HGMD	CHRNA7
	General knowledge
Family Browser	CHRNA7 [UCSC Family Browser]
SOURCE	NM_000746
SMD	Hs.511772
SAGE	Hs.511772
GO	activation of MAPK activity [Amigo]  activation of MAPK activity
GO	beta-amyloid binding [Amigo]  beta-amyloid binding
GO	response to hypoxia [Amigo]  response to hypoxia
GO	positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure [Amigo]  positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure
GO	nicotinic acetylcholine-activated cation-selective channel activity [Amigo]  nicotinic acetylcholine-activated cation-selective channel activity
GO	ion channel activity [Amigo]  ion channel activity
GO	extracellular ligand-gated ion channel activity [Amigo]  extracellular ligand-gated ion channel activity
GO	membrane fraction [Amigo]  membrane fraction
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	nicotinic acetylcholine-gated receptor-channel complex [Amigo]  nicotinic acetylcholine-gated receptor-channel complex
GO	ion transport [Amigo]  ion transport
GO	ion transport [Amigo]  ion transport
GO	calcium ion transport [Amigo]  calcium ion transport
GO	calcium ion transport [Amigo]  calcium ion transport
GO	cellular calcium ion homeostasis [Amigo]  cellular calcium ion homeostasis
GO	signal transduction [Amigo]  signal transduction
GO	synaptic transmission, cholinergic [Amigo]  synaptic transmission, cholinergic
GO	memory [Amigo]  memory
GO	drug binding [Amigo]  drug binding
GO	adenylate cyclase binding [Amigo]  adenylate cyclase binding
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	associative learning [Amigo]  associative learning
GO	external side of plasma membrane [Amigo]  external side of plasma membrane
GO	regulation of norepinephrine secretion [Amigo]  regulation of norepinephrine secretion
GO	postsynaptic density [Amigo]  postsynaptic density
GO	acetylcholine receptor activity [Amigo]  acetylcholine receptor activity
GO	toxin binding [Amigo]  toxin binding
GO	integral to membrane [Amigo]  integral to membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	apical plasma membrane [Amigo]  apical plasma membrane
GO	chloride channel regulator activity [Amigo]  chloride channel regulator activity
GO	regulation of action potential in neuron [Amigo]  regulation of action potential in neuron
GO	cell junction [Amigo]  cell junction
GO	sperm motility [Amigo]  sperm motility
GO	axon [Amigo]  axon
GO	growth cone [Amigo]  growth cone
GO	neurotransmitter receptor activity [Amigo]  neurotransmitter receptor activity
GO	response to food [Amigo]  response to food
GO	regulation of synaptic transmission, dopaminergic [Amigo]  regulation of synaptic transmission, dopaminergic
GO	asymmetric synapse [Amigo]  asymmetric synapse
GO	negative regulation of interleukin-1 beta production [Amigo]  negative regulation of interleukin-1 beta production
GO	negative regulation of interleukin-6 production [Amigo]  negative regulation of interleukin-6 production
GO	negative regulation of tumor necrosis factor production [Amigo]  negative regulation of tumor necrosis factor production
GO	response to nicotine [Amigo]  response to nicotine
GO	T cell activation [Amigo]  T cell activation
GO	B cell activation [Amigo]  B cell activation
GO	regulation of membrane potential [Amigo]  regulation of membrane potential
GO	dopamine biosynthetic process [Amigo]  dopamine biosynthetic process
GO	ovulation cycle [Amigo]  ovulation cycle
GO	presynaptic membrane [Amigo]  presynaptic membrane
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	cell soma [Amigo]  cell soma
GO	dendritic spine [Amigo]  dendritic spine
GO	dendritic shaft [Amigo]  dendritic shaft
GO	membrane raft [Amigo]  membrane raft
GO	postsynaptic membrane [Amigo]  postsynaptic membrane
GO	positive regulation of angiogenesis [Amigo]  positive regulation of angiogenesis
GO	behavioral response to ethanol [Amigo]  behavioral response to ethanol
GO	negative regulation of inflammatory response [Amigo]  negative regulation of inflammatory response
GO	cognition [Amigo]  cognition
GO	cognition [Amigo]  cognition
GO	generation of ovulation cycle rhythm [Amigo]  generation of ovulation cycle rhythm
KEGG	Calcium signaling pathway
PubGene	CHRNA7
TreeFam	CHRNA7
CTD	1139 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CHRNA7 Related clones (RZPD - Berlin)
	PubMed
PubMed	104 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:05:04 2008