Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

Identity

Alias_namesnicotinic
alpha 7 (neuronal)
Other aliasCHRNA7-2
NACHRA7
HGNC (Hugo) CHRNA7
LocusID (NCBI) 1139
Atlas_Id 45735
Location 15q13.3  [Link to chromosome band 15q13]
Location_base_pair Starts at 32030483 and ends at 32170183 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHRNA7 (15q13.3) / DKFZP434L187 (15q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNA7   1960
Cards
Entrez_Gene (NCBI)CHRNA7  1139  cholinergic receptor nicotinic alpha 7 subunit
AliasesCHRNA7-2; NACHRA7
GeneCards (Weizmann)CHRNA7
Ensembl hg19 (Hinxton)ENSG00000175344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175344 [Gene_View]  chr15:32030483-32170183 [Contig_View]  CHRNA7 [Vega]
ICGC DataPortalENSG00000175344
TCGA cBioPortalCHRNA7
AceView (NCBI)CHRNA7
Genatlas (Paris)CHRNA7
WikiGenes1139
SOURCE (Princeton)CHRNA7
Genetics Home Reference (NIH)CHRNA7
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNA7  -     chr15:32030483-32170183 +  15q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNA7  -     15q13.3   [Description]    (hg19-Feb_2009)
EnsemblCHRNA7 - 15q13.3 [CytoView hg19]  CHRNA7 - 15q13.3 [CytoView hg38]
Mapping of homologs : NCBICHRNA7 [Mapview hg19]  CHRNA7 [Mapview hg38]
OMIM118511   612001   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_000746 NM_001190455
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_009216 NT_187660 NW_011332701 NW_012132920
Consensus coding sequences : CCDS (NCBI)CHRNA7
Cluster EST : UnigeneHs.713151 [ NCBI ]
CGAP (NCI)Hs.713151
Alternative Splicing GalleryENSG00000175344
Gene ExpressionCHRNA7 [ NCBI-GEO ]   CHRNA7 [ EBI - ARRAY_EXPRESS ]   CHRNA7 [ SEEK ]   CHRNA7 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNA7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1139
GTEX Portal (Tissue expression)CHRNA7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36544   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36544  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36544
Splice isoforms : SwissVarP36544
PhosPhoSitePlusP36544
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNA7
DMDM Disease mutations1139
Blocks (Seattle)CHRNA7
PDB (SRS)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
PDB (PDBSum)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
PDB (IMB)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
PDB (RSDB)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
Structural Biology KnowledgeBase2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
SCOP (Structural Classification of Proteins)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
CATH (Classification of proteins structures)2MAW    5AFH    5AFJ    5AFK    5AFL    5AFM    5AFN   
SuperfamilyP36544
Human Protein AtlasENSG00000175344
Peptide AtlasP36544
HPRD00339
IPIIPI00942337   IPI00890702   IPI00890784   IPI00890806   IPI00003858   
Protein Interaction databases
DIP (DOE-UCLA)P36544
IntAct (EBI)P36544
FunCoupENSG00000175344
BioGRIDCHRNA7
STRING (EMBL)CHRNA7
ZODIACCHRNA7
Ontologies - Pathways
QuickGOP36544
Ontology : AmiGOactivation of MAPK activity  beta-amyloid binding  response to hypoxia  positive regulation of protein phosphorylation  ion channel activity  calcium channel activity  protein binding  plasma membrane  plasma membrane  acetylcholine-gated channel complex  ion transport  calcium ion transport  calcium ion transport  cellular calcium ion homeostasis  signal transduction  learning or memory  memory  memory  short-term memory  positive regulation of cell proliferation  ligand-gated ion channel activity  ligand-gated ion channel activity  acetylcholine receptor activity  acetylcholine receptor activity  toxic substance binding  integral component of membrane  chloride channel regulator activity  acetylcholine-gated cation-selective channel activity  cell junction  negative regulation of tumor necrosis factor production  negative regulation of tumor necrosis factor production  ion transmembrane transport  response to nicotine  response to nicotine  acetylcholine binding  protein homodimerization activity  postsynaptic membrane  positive regulation of angiogenesis  dendrite morphogenesis  synapse organization  cognition  cognition  sensory processing  positive regulation of protein metabolic process  excitatory postsynaptic potential  long-term synaptic potentiation  positive regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  acetylcholine receptor signaling pathway  dendritic spine organization  postsynapse  regulation of neuron death  positive regulation of beta-amyloid formation  negative regulation of beta-amyloid formation  regulation of amyloid precursor protein catabolic process  response to beta-amyloid  response to acetylcholine  response to acetylcholine  regulation of amyloid fibril formation  positive regulation of CoA-transferase activity  positive regulation of excitatory postsynaptic potential  
Ontology : EGO-EBIactivation of MAPK activity  beta-amyloid binding  response to hypoxia  positive regulation of protein phosphorylation  ion channel activity  calcium channel activity  protein binding  plasma membrane  plasma membrane  acetylcholine-gated channel complex  ion transport  calcium ion transport  calcium ion transport  cellular calcium ion homeostasis  signal transduction  learning or memory  memory  memory  short-term memory  positive regulation of cell proliferation  ligand-gated ion channel activity  ligand-gated ion channel activity  acetylcholine receptor activity  acetylcholine receptor activity  toxic substance binding  integral component of membrane  chloride channel regulator activity  acetylcholine-gated cation-selective channel activity  cell junction  negative regulation of tumor necrosis factor production  negative regulation of tumor necrosis factor production  ion transmembrane transport  response to nicotine  response to nicotine  acetylcholine binding  protein homodimerization activity  postsynaptic membrane  positive regulation of angiogenesis  dendrite morphogenesis  synapse organization  cognition  cognition  sensory processing  positive regulation of protein metabolic process  excitatory postsynaptic potential  long-term synaptic potentiation  positive regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  acetylcholine receptor signaling pathway  dendritic spine organization  postsynapse  regulation of neuron death  positive regulation of beta-amyloid formation  negative regulation of beta-amyloid formation  regulation of amyloid precursor protein catabolic process  response to beta-amyloid  response to acetylcholine  response to acetylcholine  regulation of amyloid fibril formation  positive regulation of CoA-transferase activity  positive regulation of excitatory postsynaptic potential  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Cholinergic synapse    Nicotine addiction    Chemical carcinogenesis   
NDEx NetworkCHRNA7
Atlas of Cancer Signalling NetworkCHRNA7
Wikipedia pathwaysCHRNA7
Orthology - Evolution
OrthoDB1139
GeneTree (enSembl)ENSG00000175344
Phylogenetic Trees/Animal Genes : TreeFamCHRNA7
HOVERGENP36544
HOGENOMP36544
Homologs : HomoloGeneCHRNA7
Homology/Alignments : Family Browser (UCSC)CHRNA7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNA7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNA7
dbVarCHRNA7
ClinVarCHRNA7
1000_GenomesCHRNA7 
Exome Variant ServerCHRNA7
ExAC (Exome Aggregation Consortium)CHRNA7 (select the gene name)
Genetic variants : HAPMAP1139
Genomic Variants (DGV)CHRNA7 [DGVbeta]
DECIPHERCHRNA7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNA7 
Mutations
ICGC Data PortalCHRNA7 
TCGA Data PortalCHRNA7 
Broad Tumor PortalCHRNA7
OASIS PortalCHRNA7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNA7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNA7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNA7
DgiDB (Drug Gene Interaction Database)CHRNA7
DoCM (Curated mutations)CHRNA7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNA7 (select a term)
intoGenCHRNA7
Cancer3DCHRNA7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118511    612001   
Orphanet18399   
MedgenCHRNA7
Genetic Testing Registry CHRNA7
NextProtP36544 [Medical]
TSGene1139
GENETestsCHRNA7
Target ValidationCHRNA7
Huge Navigator CHRNA7 [HugePedia]
snp3D : Map Gene to Disease1139
BioCentury BCIQCHRNA7
ClinGenCHRNA7 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1139
Chemical/Pharm GKB GenePA114
Clinical trialCHRNA7
Miscellaneous
canSAR (ICR)CHRNA7 (select the gene name)
Probes
Litterature
PubMed246 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNA7
EVEXCHRNA7
GoPubMedCHRNA7
iHOPCHRNA7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:24 CEST 2017

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