Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)

Identity

Alias_namesnicotinic
beta 4 (neuronal)
Other alias-
HGNC (Hugo) CHRNB4
LocusID (NCBI) 1143
Atlas_Id 52258
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78624294 and ends at 78641245 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHRNB4   1964
Cards
Entrez_Gene (NCBI)CHRNB4  1143  cholinergic receptor nicotinic beta 4 subunit
Aliases
GeneCards (Weizmann)CHRNB4
Ensembl hg19 (Hinxton)ENSG00000117971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117971 [Gene_View]  chr15:78624294-78641245 [Contig_View]  CHRNB4 [Vega]
ICGC DataPortalENSG00000117971
TCGA cBioPortalCHRNB4
AceView (NCBI)CHRNB4
Genatlas (Paris)CHRNB4
WikiGenes1143
SOURCE (Princeton)CHRNB4
Genetics Home Reference (NIH)CHRNB4
Genomic and cartography
GoldenPath hg38 (UCSC)CHRNB4  -     chr15:78624294-78641245 -  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHRNB4  -     15q25.1   [Description]    (hg19-Feb_2009)
EnsemblCHRNB4 - 15q25.1 [CytoView hg19]  CHRNB4 - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBICHRNB4 [Mapview hg19]  CHRNB4 [Mapview hg38]
OMIM118509   
Gene and transcription
Genbank (Entrez)AK310443 BC096080 BC096081 BC096082 BC096083
RefSeq transcript (Entrez)NM_000750 NM_001256567
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHRNB4
Cluster EST : UnigeneHs.624178 [ NCBI ]
CGAP (NCI)Hs.624178
Alternative Splicing GalleryENSG00000117971
Gene ExpressionCHRNB4 [ NCBI-GEO ]   CHRNB4 [ EBI - ARRAY_EXPRESS ]   CHRNB4 [ SEEK ]   CHRNB4 [ MEM ]
Gene Expression Viewer (FireBrowse)CHRNB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1143
GTEX Portal (Tissue expression)CHRNB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30926   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30926  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30926
Splice isoforms : SwissVarP30926
PhosPhoSitePlusP30926
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS    Nicotinic_acetylcholine_rcpt   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)CHRNB4
DMDM Disease mutations1143
Blocks (Seattle)CHRNB4
PDB (SRS)2ASG   
PDB (PDBSum)2ASG   
PDB (IMB)2ASG   
PDB (RSDB)2ASG   
Structural Biology KnowledgeBase2ASG   
SCOP (Structural Classification of Proteins)2ASG   
CATH (Classification of proteins structures)2ASG   
SuperfamilyP30926
Human Protein AtlasENSG00000117971
Peptide AtlasP30926
HPRD00337
IPIIPI00028080   IPI00843891   
Protein Interaction databases
DIP (DOE-UCLA)P30926
IntAct (EBI)P30926
FunCoupENSG00000117971
BioGRIDCHRNB4
STRING (EMBL)CHRNB4
ZODIACCHRNB4
Ontologies - Pathways
QuickGOP30926
Ontology : AmiGOaction potential  protein binding  plasma membrane  integral component of plasma membrane  acetylcholine-gated channel complex  acetylcholine-gated channel complex  ion transport  smooth muscle contraction  regulation of smooth muscle contraction  signal transduction  synaptic transmission, cholinergic  locomotory behavior  drug binding  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  behavioral response to nicotine  specific granule membrane  acetylcholine binding  neuron projection  neutrophil degranulation  postsynaptic membrane  regulation of neurotransmitter secretion  protein heterodimerization activity  protein heterooligomerization  positive regulation of transmission of nerve impulse  excitatory postsynaptic potential  synaptic transmission involved in micturition  tertiary granule membrane  cation transmembrane transport  
Ontology : EGO-EBIaction potential  protein binding  plasma membrane  integral component of plasma membrane  acetylcholine-gated channel complex  acetylcholine-gated channel complex  ion transport  smooth muscle contraction  regulation of smooth muscle contraction  signal transduction  synaptic transmission, cholinergic  locomotory behavior  drug binding  ligand-gated ion channel activity  acetylcholine receptor activity  integral component of membrane  acetylcholine-gated cation-selective channel activity  acetylcholine-gated cation-selective channel activity  cell junction  response to nicotine  behavioral response to nicotine  specific granule membrane  acetylcholine binding  neuron projection  neutrophil degranulation  postsynaptic membrane  regulation of neurotransmitter secretion  protein heterodimerization activity  protein heterooligomerization  positive regulation of transmission of nerve impulse  excitatory postsynaptic potential  synaptic transmission involved in micturition  tertiary granule membrane  cation transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Cholinergic synapse   
NDEx NetworkCHRNB4
Atlas of Cancer Signalling NetworkCHRNB4
Wikipedia pathwaysCHRNB4
Orthology - Evolution
OrthoDB1143
GeneTree (enSembl)ENSG00000117971
Phylogenetic Trees/Animal Genes : TreeFamCHRNB4
HOVERGENP30926
HOGENOMP30926
Homologs : HomoloGeneCHRNB4
Homology/Alignments : Family Browser (UCSC)CHRNB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHRNB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHRNB4
dbVarCHRNB4
ClinVarCHRNB4
1000_GenomesCHRNB4 
Exome Variant ServerCHRNB4
ExAC (Exome Aggregation Consortium)CHRNB4 (select the gene name)
Genetic variants : HAPMAP1143
Genomic Variants (DGV)CHRNB4 [DGVbeta]
DECIPHERCHRNB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHRNB4 
Mutations
ICGC Data PortalCHRNB4 
TCGA Data PortalCHRNB4 
Broad Tumor PortalCHRNB4
OASIS PortalCHRNB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHRNB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHRNB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHRNB4
DgiDB (Drug Gene Interaction Database)CHRNB4
DoCM (Curated mutations)CHRNB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHRNB4 (select a term)
intoGenCHRNB4
Cancer3DCHRNB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118509   
Orphanet
MedgenCHRNB4
Genetic Testing Registry CHRNB4
NextProtP30926 [Medical]
TSGene1143
GENETestsCHRNB4
Target ValidationCHRNB4
Huge Navigator CHRNB4 [HugePedia]
snp3D : Map Gene to Disease1143
BioCentury BCIQCHRNB4
ClinGenCHRNB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1143
Chemical/Pharm GKB GenePA26496
Clinical trialCHRNB4
Miscellaneous
canSAR (ICR)CHRNB4 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHRNB4
EVEXCHRNB4
GoPubMedCHRNB4
iHOPCHRNB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:28:25 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.