CHST2 (carbohydrate sulfotransferase 2)

2007-12-01 Affiliation

Identity

HGNC

CHST2

LOCATION

3q24

LOCUSID

9435

ALIAS

C6ST,GST-2,GST2,Gn6ST-1,HEL-S-75,glcNAc6ST-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9435
MIM: 603798
HGNC: 1970
Ensembl: ENSG00000175040

Variants:

dbSNP: 9435
ClinVar: 9435
TCGA: ENSG00000175040
COSMIC: CHST2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175040	ENST00000309575	Q9Y4C5
ENSG00000175040	ENST00000309575	V9HVX9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	ko00533
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	hsa00533
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854

References

Pubmed ID	Year	Title	Citations
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	48
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	16
12855678	2003	Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.	7
28320965	2017	Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.	5
19571171	2009	Effects of N-glycosylation on the activity and localization of GlcNAc-6-sulfotransferase 1.	4
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	3
24799377	2014	Detecting O-GlcNAc using in vitro sulfation.	3
30093410	2018	Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.	2
16897186	2006	Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas.	0

Citation

Dessen P

CHST2 (carbohydrate sulfotransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49854/chst2