Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CHUK (component of inhibitor of nuclear factor kappa B kinase complex)

Identity

Alias_namesTCF16
conserved helix-loop-helix ubiquitous kinase
Alias_symbol (synonym)IKK1
IKK-alpha
IkBKA
NFKBIKA
IKKA
Other aliasIKBKA
HGNC (Hugo) CHUK
LocusID (NCBI) 1147
Atlas_Id 40081
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100188298 and ends at 100229610 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHUK (10q24.31) / CHMP1A (16q24.3)HDAC7 (12q13.11) / CHUK (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CHUK   1974
Cards
Entrez_Gene (NCBI)CHUK  1147  component of inhibitor of nuclear factor kappa B kinase complex
AliasesIKBKA; IKK-alpha; IKK1; IKKA; 
NFKBIKA; TCF16
GeneCards (Weizmann)CHUK
Ensembl hg19 (Hinxton)ENSG00000213341 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213341 [Gene_View]  ENSG00000213341 [Sequence]  chr10:100188298-100229610 [Contig_View]  CHUK [Vega]
ICGC DataPortalENSG00000213341
TCGA cBioPortalCHUK
AceView (NCBI)CHUK
Genatlas (Paris)CHUK
WikiGenes1147
SOURCE (Princeton)CHUK
Genetics Home Reference (NIH)CHUK
Genomic and cartography
GoldenPath hg38 (UCSC)CHUK  -     chr10:100188298-100229610 -  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHUK  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathCHUK - 10q24.31 [CytoView hg19]  CHUK - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000213341
Mapping of homologs : NCBICHUK [Mapview hg19]  CHUK [Mapview hg38]
OMIM600664   613630   
Gene and transcription
Genbank (Entrez)AB209028 AF009225 AF012890 AF080157 AI829429
RefSeq transcript (Entrez)NM_001278 NM_001320928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHUK
Cluster EST : UnigeneHs.198998 [ NCBI ]
CGAP (NCI)Hs.198998
Alternative Splicing GalleryENSG00000213341
Gene ExpressionCHUK [ NCBI-GEO ]   CHUK [ EBI - ARRAY_EXPRESS ]   CHUK [ SEEK ]   CHUK [ MEM ]
Gene Expression Viewer (FireBrowse)CHUK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1147
GTEX Portal (Tissue expression)CHUK
Human Protein AtlasENSG00000213341-CHUK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15111   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15111  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15111
Splice isoforms : SwissVarO15111
Catalytic activity : Enzyme2.7.11.10 [ Enzyme-Expasy ]   2.7.11.102.7.11.10 [ IntEnz-EBI ]   2.7.11.10 [ BRENDA ]   2.7.11.10 [ KEGG ]   
PhosPhoSitePlusO15111
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)IKKbetaNEMObind    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)IKKbetaNEMObind (PF12179)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12179    pfam00069   
Domain families : Smart (EMBL)IKKbetaNEMObind (SM01239)  S_TKc (SM00220)  
Conserved Domain (NCBI)CHUK
DMDM Disease mutations1147
Blocks (Seattle)CHUK
PDB (RSDB)3BRT    5EBZ    5TQW    5TQX    5TQY   
PDB Europe3BRT    5EBZ    5TQW    5TQX    5TQY   
PDB (PDBSum)3BRT    5EBZ    5TQW    5TQX    5TQY   
PDB (IMB)3BRT    5EBZ    5TQW    5TQX    5TQY   
Structural Biology KnowledgeBase3BRT    5EBZ    5TQW    5TQX    5TQY   
SCOP (Structural Classification of Proteins)3BRT    5EBZ    5TQW    5TQX    5TQY   
CATH (Classification of proteins structures)3BRT    5EBZ    5TQW    5TQX    5TQY   
SuperfamilyO15111
Human Protein Atlas [tissue]ENSG00000213341-CHUK [tissue]
Peptide AtlasO15111
HPRD02811
IPIIPI00005104   
Protein Interaction databases
DIP (DOE-UCLA)O15111
IntAct (EBI)O15111
FunCoupENSG00000213341
BioGRIDCHUK
STRING (EMBL)CHUK
ZODIACCHUK
Ontologies - Pathways
QuickGOO15111
Ontology : AmiGOstimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  MyD88-independent toll-like receptor signaling pathway  skeletal muscle contraction  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB kinase/NF-kappaB signaling  I-kappaB phosphorylation  Rho protein signal transduction  IkappaB kinase activity  IkappaB kinase activity  IkappaB kinase complex  IkappaB kinase complex  response to virus  response to toxic substance  anatomical structure morphogenesis  cytoplasmic side of plasma membrane  response to acetate  regulation of tumor necrosis factor-mediated signaling pathway  peptidyl-serine phosphorylation  negative regulation of NF-kappaB transcription factor activity  response to lipopolysaccharide  response to hydroperoxide  tumor necrosis factor-mediated signaling pathway  cellular response to reactive oxygen species  CD40 receptor complex  TRIF-dependent toll-like receptor signaling pathway  NIK/NF-kappaB signaling  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  response to drug  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  intracellular membrane-bounded organelle  innate immune response  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  stress-activated MAPK cascade  response to cholecystokinin  interleukin-1-mediated signaling pathway  cellular response to cadmium ion  cellular response to tumor necrosis factor  scaffold protein binding  cellular response to virus  positive regulation of interferon-alpha secretion  
Ontology : EGO-EBIstimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  MyD88-independent toll-like receptor signaling pathway  skeletal muscle contraction  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB kinase/NF-kappaB signaling  I-kappaB phosphorylation  Rho protein signal transduction  IkappaB kinase activity  IkappaB kinase activity  IkappaB kinase complex  IkappaB kinase complex  response to virus  response to toxic substance  anatomical structure morphogenesis  cytoplasmic side of plasma membrane  response to acetate  regulation of tumor necrosis factor-mediated signaling pathway  peptidyl-serine phosphorylation  negative regulation of NF-kappaB transcription factor activity  response to lipopolysaccharide  response to hydroperoxide  tumor necrosis factor-mediated signaling pathway  cellular response to reactive oxygen species  CD40 receptor complex  TRIF-dependent toll-like receptor signaling pathway  NIK/NF-kappaB signaling  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  response to drug  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  intracellular membrane-bounded organelle  innate immune response  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  stress-activated MAPK cascade  response to cholecystokinin  interleukin-1-mediated signaling pathway  cellular response to cadmium ion  cellular response to tumor necrosis factor  scaffold protein binding  cellular response to virus  positive regulation of interferon-alpha secretion  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Chemokine signaling pathway    NF-kappa B signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Adipocytokine signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Hepatitis C    Hepatitis B    Measles    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Pancreatic cancer    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Small cell lung cancer   
NDEx NetworkCHUK
Atlas of Cancer Signalling NetworkCHUK
Wikipedia pathwaysCHUK
Orthology - Evolution
OrthoDB1147
GeneTree (enSembl)ENSG00000213341
Phylogenetic Trees/Animal Genes : TreeFamCHUK
HOGENOMO15111
Homologs : HomoloGeneCHUK
Homology/Alignments : Family Browser (UCSC)CHUK
Gene fusions - Rearrangements
Fusion : QuiverCHUK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHUK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHUK
dbVarCHUK
ClinVarCHUK
1000_GenomesCHUK 
Exome Variant ServerCHUK
ExAC (Exome Aggregation Consortium)ENSG00000213341
GNOMAD BrowserENSG00000213341
Varsome BrowserCHUK
Genetic variants : HAPMAP1147
Genomic Variants (DGV)CHUK [DGVbeta]
DECIPHERCHUK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHUK 
Mutations
ICGC Data PortalCHUK 
TCGA Data PortalCHUK 
Broad Tumor PortalCHUK
OASIS PortalCHUK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHUK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCHUK
Mutations and Diseases : HGMDCHUK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHUK
DgiDB (Drug Gene Interaction Database)CHUK
DoCM (Curated mutations)CHUK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHUK (select a term)
intoGenCHUK
Cancer3DCHUK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600664    613630   
Orphanet
DisGeNETCHUK
MedgenCHUK
Genetic Testing Registry CHUK
NextProtO15111 [Medical]
TSGene1147
GENETestsCHUK
Target ValidationCHUK
Huge Navigator CHUK [HugePedia]
snp3D : Map Gene to Disease1147
BioCentury BCIQCHUK
ClinGenCHUK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1147
Chemical/Pharm GKB GenePA26510
Clinical trialCHUK
Miscellaneous
canSAR (ICR)CHUK (select the gene name)
DataMed IndexCHUK
Probes
Litterature
PubMed481 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHUK
EVEXCHUK
GoPubMedCHUK
iHOPCHUK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:03:23 CEST 2019
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