Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CIB1 (calcium and integrin binding 1)

Identity

Alias (NCBI)CIB
CIBP
KIP1
PRKDCIP
SIP2-28
HGNC (Hugo) CIB1
HGNC Alias symbSIP2-28
CIB
KIP
HGNC Alias namecalmyrin
LocusID (NCBI) 10519
Atlas_Id 40083
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90229975 and ends at 90233941 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CIB1 (15q26.1) / SPCS1 (3p21.1)LOC729041 () / CIB1 (15q26.1)OSBP2 (22q12.2) / CIB1 (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CIB1   16920
Cards
Entrez_Gene (NCBI)CIB1  10519  calcium and integrin binding 1
AliasesCIB; CIBP; KIP1; PRKDCIP; 
SIP2-28
GeneCards (Weizmann)CIB1
Ensembl hg19 (Hinxton)ENSG00000185043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185043 [Gene_View]  ENSG00000185043 [Sequence]  chr15:90229975-90233941 [Contig_View]  CIB1 [Vega]
ICGC DataPortalENSG00000185043
TCGA cBioPortalCIB1
AceView (NCBI)CIB1
Genatlas (Paris)CIB1
WikiGenes10519
SOURCE (Princeton)CIB1
Genetics Home Reference (NIH)CIB1
Genomic and cartography
GoldenPath hg38 (UCSC)CIB1  -     chr15:90229975-90233941 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CIB1  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathCIB1 - 15q26.1 [CytoView hg19]  CIB1 - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000185043
genome Data Viewer NCBICIB1 [Mapview hg19]  
OMIM602293   618267   
Gene and transcription
Genbank (Entrez)AA769426 AB451276 AB451406 BC000846 BG231771
RefSeq transcript (Entrez)NM_001277764 NM_006384
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CIB1
Alternative Splicing GalleryENSG00000185043
Gene ExpressionCIB1 [ NCBI-GEO ]   CIB1 [ EBI - ARRAY_EXPRESS ]   CIB1 [ SEEK ]   CIB1 [ MEM ]
Gene Expression Viewer (FireBrowse)CIB1 [ Firebrowse - Broad ]
GenevisibleExpression of CIB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10519
GTEX Portal (Tissue expression)CIB1
Human Protein AtlasENSG00000185043-CIB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99828   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99828  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99828
Splice isoforms : SwissVarQ99828
PhosPhoSitePlusQ99828
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)CIB1
DMDM Disease mutations10519
Blocks (Seattle)CIB1
PDB (RSDB)1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
PDB Europe1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
PDB (PDBSum)1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
PDB (IMB)1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
Structural Biology KnowledgeBase1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
SCOP (Structural Classification of Proteins)1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
CATH (Classification of proteins structures)1DGU    1DGV    1XO5    1Y1A    2L4H    2L4I    2LM5   
SuperfamilyQ99828
Human Protein Atlas [tissue]ENSG00000185043-CIB1 [tissue]
Peptide AtlasQ99828
HPRD03800
IPIIPI00018451   
Protein Interaction databases
DIP (DOE-UCLA)Q99828
IntAct (EBI)Q99828
FunCoupENSG00000185043
BioGRIDCIB1
STRING (EMBL)CIB1
ZODIACCIB1
Ontologies - Pathways
QuickGOQ99828
Ontology : AmiGOangiogenesis  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of cell-matrix adhesion  response to ischemia  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  endoplasmic reticulum  Golgi apparatus  centrosome  plasma membrane  double-strand break repair  apoptotic process  cellular response to DNA damage stimulus  negative regulation of microtubule depolymerization  endomitotic cell cycle  cell adhesion  spermatid development  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  calcium-dependent protein kinase inhibitor activity  negative regulation of neuron projection development  membrane  apical plasma membrane  Ras GTPase binding  protein kinase binding  lamellipodium  platelet formation  protein serine/threonine kinase inhibitor activity  positive regulation of cell growth  positive regulation of cell migration  dendrite  growth cone  cytoplasmic microtubule organization  vesicle  filopodium tip  ruffle membrane  positive regulation of cell adhesion mediated by integrin  thrombopoietin-mediated signaling pathway  regulation of cell proliferation  sarcolemma  neuron projection  neuronal cell body  negative regulation of apoptotic process  positive regulation of catalytic activity  perikaryon  protein membrane anchor  ion channel binding  negative regulation of megakaryocyte differentiation  perinuclear region of cytoplasm  positive regulation of NF-kappaB transcription factor activity  cell division  regulation of cell division  negative regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of calcineurin-NFAT signaling cascade  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  negative regulation of protein serine/threonine kinase activity  positive regulation of protein serine/threonine kinase activity  cell periphery  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of protein targeting to membrane  extrinsic apoptotic signaling pathway  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of protein localization to plasma membrane  cellular response to nerve growth factor stimulus  positive regulation of male germ cell proliferation  
Ontology : EGO-EBIangiogenesis  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of cell-matrix adhesion  response to ischemia  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  endoplasmic reticulum  Golgi apparatus  centrosome  plasma membrane  double-strand break repair  apoptotic process  cellular response to DNA damage stimulus  negative regulation of microtubule depolymerization  endomitotic cell cycle  cell adhesion  spermatid development  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  calcium-dependent protein kinase inhibitor activity  negative regulation of neuron projection development  membrane  apical plasma membrane  Ras GTPase binding  protein kinase binding  lamellipodium  platelet formation  protein serine/threonine kinase inhibitor activity  positive regulation of cell growth  positive regulation of cell migration  dendrite  growth cone  cytoplasmic microtubule organization  vesicle  filopodium tip  ruffle membrane  positive regulation of cell adhesion mediated by integrin  thrombopoietin-mediated signaling pathway  regulation of cell proliferation  sarcolemma  neuron projection  neuronal cell body  negative regulation of apoptotic process  positive regulation of catalytic activity  perikaryon  protein membrane anchor  ion channel binding  negative regulation of megakaryocyte differentiation  perinuclear region of cytoplasm  positive regulation of NF-kappaB transcription factor activity  cell division  regulation of cell division  negative regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of calcineurin-NFAT signaling cascade  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  negative regulation of protein serine/threonine kinase activity  positive regulation of protein serine/threonine kinase activity  cell periphery  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of protein targeting to membrane  extrinsic apoptotic signaling pathway  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of protein localization to plasma membrane  cellular response to nerve growth factor stimulus  positive regulation of male germ cell proliferation  
NDEx NetworkCIB1
Atlas of Cancer Signalling NetworkCIB1
Wikipedia pathwaysCIB1
Orthology - Evolution
OrthoDB10519
GeneTree (enSembl)ENSG00000185043
Phylogenetic Trees/Animal Genes : TreeFamCIB1
HOGENOMQ99828
Homologs : HomoloGeneCIB1
Homology/Alignments : Family Browser (UCSC)CIB1
Gene fusions - Rearrangements
Fusion : QuiverCIB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCIB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CIB1
dbVarCIB1
ClinVarCIB1
1000_GenomesCIB1 
Exome Variant ServerCIB1
GNOMAD BrowserENSG00000185043
Varsome BrowserCIB1
Genetic variants : HAPMAP10519
Genomic Variants (DGV)CIB1 [DGVbeta]
DECIPHERCIB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCIB1 
Mutations
ICGC Data PortalCIB1 
TCGA Data PortalCIB1 
Broad Tumor PortalCIB1
OASIS PortalCIB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCIB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCIB1
Mutations and Diseases : HGMDCIB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CIB1
DgiDB (Drug Gene Interaction Database)CIB1
DoCM (Curated mutations)CIB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CIB1 (select a term)
intoGenCIB1
Cancer3DCIB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602293    618267   
Orphanet
DisGeNETCIB1
MedgenCIB1
Genetic Testing Registry CIB1
NextProtQ99828 [Medical]
TSGene10519
GENETestsCIB1
Target ValidationCIB1
Huge Navigator CIB1 [HugePedia]
snp3D : Map Gene to Disease10519
BioCentury BCIQCIB1
ClinGenCIB1
Clinical trials, drugs, therapy
Protein Interactions : CTD10519
Pharm GKB GenePA38423
Clinical trialCIB1
Miscellaneous
canSAR (ICR)CIB1 (select the gene name)
HarmonizomeCIB1
DataMed IndexCIB1
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCIB1
EVEXCIB1
GoPubMedCIB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:07:54 CEST 2020
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