Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CILK1 (ciliogenesis associated kinase 1)

Identity

Alias (NCBI)ECO
EJM10
ICK
LCK2
MRK
hICK
HGNC (Hugo) CILK1
HGNC Alias symbMRK
LCK2
KIAA0936
MGC46090
HGNC Alias nameserine/threonine-protein kinase ICK
 MAK-related kinase
HGNC Previous nameintestinal cell (MAK-like) kinase
LocusID (NCBI) 22858
Atlas_Id 43313
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 53001306 and ends at 53061824 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRMT11 6q22.32 / ICK 6p12.2
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p12;q22) TRMT11/ICK


External links

Nomenclature
HGNC (Hugo)CILK1   21219
Cards
Entrez_Gene (NCBI)CILK1  22858  ciliogenesis associated kinase 1
AliasesECO; EJM10; ICK; LCK2; 
MRK; hICK
GeneCards (Weizmann)CILK1
Ensembl hg19 (Hinxton)ENSG00000112144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112144 [Gene_View]  ENSG00000112144 [Sequence]  chr6:53001306-53061824 [Contig_View]  CILK1 [Vega]
ICGC DataPortalENSG00000112144
TCGA cBioPortalCILK1
AceView (NCBI)CILK1
Genatlas (Paris)CILK1
WikiGenes22858
SOURCE (Princeton)CILK1
Genetics Home Reference (NIH)CILK1
Genomic and cartography
GoldenPath hg38 (UCSC)CILK1  -     chr6:53001306-53061824 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CILK1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathCILK1 - - [CytoView hg19]  CILK1 - - [CytoView hg38]
ImmunoBaseENSG00000112144
genome Data Viewer NCBICILK1 [Mapview hg19]  
OMIM612325   612651   617924   
Gene and transcription
Genbank (Entrez)AB023153 AF152469 AF225919 AI699136 AJ420557
RefSeq transcript (Entrez)NM_001375397 NM_001375398 NM_001375399 NM_001375400 NM_001375401 NM_001375402 NM_014920 NM_016513
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CILK1
Alternative Splicing GalleryENSG00000112144
Gene ExpressionCILK1 [ NCBI-GEO ]   CILK1 [ EBI - ARRAY_EXPRESS ]   CILK1 [ SEEK ]   CILK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CILK1 [ Firebrowse - Broad ]
GenevisibleExpression of CILK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22858
GTEX Portal (Tissue expression)CILK1
Human Protein AtlasENSG00000112144-CILK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPZ9
Splice isoforms : SwissVarQ9UPZ9
PhosPhoSitePlusQ9UPZ9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CILK1
DMDM Disease mutations22858
Blocks (Seattle)CILK1
SuperfamilyQ9UPZ9
Human Protein Atlas [tissue]ENSG00000112144-CILK1 [tissue]
Peptide AtlasQ9UPZ9
HPRD09996
IPIIPI00414132   IPI00217776   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPZ9
IntAct (EBI)Q9UPZ9
FunCoupENSG00000112144
BioGRIDCILK1
STRING (EMBL)CILK1
ZODIACCILK1
Ontologies - Pathways
QuickGOQ9UPZ9
Ontology : AmiGOmagnesium ion binding  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  cytosol  cilium  cilium  protein phosphorylation  signal transduction  multicellular organism development  regulation of gene expression  intracellular signal transduction  intracellular signal transduction  intraciliary anterograde transport  intraciliary retrograde transport  ciliary basal body  intraciliary transport  intraciliary transport  cilium assembly  cilium assembly  ciliary tip  ciliary base  
Ontology : EGO-EBImagnesium ion binding  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  cytosol  cilium  cilium  protein phosphorylation  signal transduction  multicellular organism development  regulation of gene expression  intracellular signal transduction  intracellular signal transduction  intraciliary anterograde transport  intraciliary retrograde transport  ciliary basal body  intraciliary transport  intraciliary transport  cilium assembly  cilium assembly  ciliary tip  ciliary base  
NDEx NetworkCILK1
Atlas of Cancer Signalling NetworkCILK1
Wikipedia pathwaysCILK1
Orthology - Evolution
OrthoDB22858
GeneTree (enSembl)ENSG00000112144
Phylogenetic Trees/Animal Genes : TreeFamCILK1
HOGENOMQ9UPZ9
Homologs : HomoloGeneCILK1
Homology/Alignments : Family Browser (UCSC)CILK1
Gene fusions - Rearrangements
Fusion : MitelmanTRMT11/ICK [6q22.32/6p12.2]  
Fusion PortalTRMT11 6q22.32 ICK 6p12.2 BRCA
Fusion : QuiverCILK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCILK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CILK1
dbVarCILK1
ClinVarCILK1
MonarchCILK1
1000_GenomesCILK1 
Exome Variant ServerCILK1
GNOMAD BrowserENSG00000112144
Varsome BrowserCILK1
Genetic variants : HAPMAP22858
Genomic Variants (DGV)CILK1 [DGVbeta]
DECIPHERCILK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCILK1 
Mutations
ICGC Data PortalCILK1 
TCGA Data PortalCILK1 
Broad Tumor PortalCILK1
OASIS PortalCILK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCILK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CILK1
DgiDB (Drug Gene Interaction Database)CILK1
DoCM (Curated mutations)CILK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CILK1 (select a term)
intoGenCILK1
Cancer3DCILK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612325    612651    617924   
Orphanet18403   
DisGeNETCILK1
MedgenCILK1
Genetic Testing Registry CILK1
NextProtQ9UPZ9 [Medical]
TSGene22858
GENETestsCILK1
Target ValidationCILK1
Huge Navigator CILK1 [HugePedia]
snp3D : Map Gene to Disease22858
BioCentury BCIQCILK1
ClinGenCILK1
Clinical trials, drugs, therapy
Protein Interactions : CTD22858
Clinical trialCILK1
Miscellaneous
canSAR (ICR)CILK1 (select the gene name)
HarmonizomeCILK1
DataMed IndexCILK1
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCILK1
EVEXCILK1
GoPubMedCILK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:06:12 CEST 2020

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