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CIR1 (corepressor interacting with RBPJ, 1)

Identity

Alias_symbol (synonym)CIR
Other alias
HGNC (Hugo) CIR1
LocusID (NCBI) 9541
Atlas_Id 61836
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 174348150 and ends at 174395715 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABTB2 (11p13) / CIR1 (2q31.1)CIR1 (2q31.1) / FIP1L1 (4q12)TNFSF4 (1q25.1) / CIR1 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CIR1   24217
Cards
Entrez_Gene (NCBI)CIR1  9541  corepressor interacting with RBPJ, 1
AliasesCIR
GeneCards (Weizmann)CIR1
Ensembl hg19 (Hinxton)ENSG00000138433 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138433 [Gene_View]  chr2:174348150-174395715 [Contig_View]  CIR1 [Vega]
ICGC DataPortalENSG00000138433
TCGA cBioPortalCIR1
AceView (NCBI)CIR1
Genatlas (Paris)CIR1
WikiGenes9541
SOURCE (Princeton)CIR1
Genetics Home Reference (NIH)CIR1
Genomic and cartography
GoldenPath hg38 (UCSC)CIR1  -     chr2:174348150-174395715 -  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CIR1  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblCIR1 - 2q31.1 [CytoView hg19]  CIR1 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBICIR1 [Mapview hg19]  CIR1 [Mapview hg38]
OMIM605228   
Gene and transcription
Genbank (Entrez)AF098297 AK292389 BC015040 BC021175 BC031018
RefSeq transcript (Entrez)NM_004882 NM_199075
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CIR1
Cluster EST : UnigeneHs.632531 [ NCBI ]
CGAP (NCI)Hs.632531
Alternative Splicing GalleryENSG00000138433
Gene ExpressionCIR1 [ NCBI-GEO ]   CIR1 [ EBI - ARRAY_EXPRESS ]   CIR1 [ SEEK ]   CIR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CIR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9541
GTEX Portal (Tissue expression)CIR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86X95   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86X95  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86X95
Splice isoforms : SwissVarQ86X95
PhosPhoSitePlusQ86X95
Domains : Interpro (EBI)CIR_N_dom   
Domain families : Pfam (Sanger)Cir_N (PF10197)   
Domain families : Pfam (NCBI)pfam10197   
Domain families : Smart (EMBL)Cir_N (SM01083)  
Conserved Domain (NCBI)CIR1
DMDM Disease mutations9541
Blocks (Seattle)CIR1
SuperfamilyQ86X95
Human Protein AtlasENSG00000138433
Peptide AtlasQ86X95
HPRD05568
IPIIPI00749452   IPI00743170   IPI00916776   IPI00916870   
Protein Interaction databases
DIP (DOE-UCLA)Q86X95
IntAct (EBI)Q86X95
FunCoupENSG00000138433
BioGRIDCIR1
STRING (EMBL)CIR1
ZODIACCIR1
Ontologies - Pathways
QuickGOQ86X95
Ontology : AmiGOhistone deacetylase complex  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  microtubule organizing center  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  mRNA processing  RNA splicing  nuclear speck  negative regulation of transcription, DNA-templated  
Ontology : EGO-EBIhistone deacetylase complex  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  microtubule organizing center  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  mRNA processing  RNA splicing  nuclear speck  negative regulation of transcription, DNA-templated  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkCIR1
Atlas of Cancer Signalling NetworkCIR1
Wikipedia pathwaysCIR1
Orthology - Evolution
OrthoDB9541
GeneTree (enSembl)ENSG00000138433
Phylogenetic Trees/Animal Genes : TreeFamCIR1
HOVERGENQ86X95
HOGENOMQ86X95
Homologs : HomoloGeneCIR1
Homology/Alignments : Family Browser (UCSC)CIR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCIR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CIR1
dbVarCIR1
ClinVarCIR1
1000_GenomesCIR1 
Exome Variant ServerCIR1
ExAC (Exome Aggregation Consortium)CIR1 (select the gene name)
Genetic variants : HAPMAP9541
Genomic Variants (DGV)CIR1 [DGVbeta]
DECIPHERCIR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCIR1 
Mutations
ICGC Data PortalCIR1 
TCGA Data PortalCIR1 
Broad Tumor PortalCIR1
OASIS PortalCIR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCIR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCIR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CIR1
DgiDB (Drug Gene Interaction Database)CIR1
DoCM (Curated mutations)CIR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CIR1 (select a term)
intoGenCIR1
Cancer3DCIR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605228   
Orphanet
MedgenCIR1
Genetic Testing Registry CIR1
NextProtQ86X95 [Medical]
TSGene9541
GENETestsCIR1
Target ValidationCIR1
Huge Navigator CIR1 [HugePedia]
snp3D : Map Gene to Disease9541
BioCentury BCIQCIR1
ClinGenCIR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9541
Chemical/Pharm GKB GenePA165696415
Clinical trialCIR1
Miscellaneous
canSAR (ICR)CIR1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCIR1
EVEXCIR1
GoPubMedCIR1
iHOPCIR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:04:50 CEST 2017

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