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CISD1 (CDGSH iron sulfur domain 1)

Identity

Alias_namesC10orf70
ZCD1
chromosome 10 open reading frame 70
zinc finger, CDGSH-type domain 1
Alias_symbol (synonym)MDS029
mitoNEET
Other alias
HGNC (Hugo) CISD1
LocusID (NCBI) 55847
Atlas_Id 53917
Location 10q21.1  [Link to chromosome band 10q21]
Location_base_pair Starts at 58269102 and ends at 58289259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BICC1 (10q21.1) / CISD1 (10q21.1)CISD1 (10q21.1) / GABRA1 (5q34)IFRD1 (7q31.1) / CISD1 (10q21.1)
CISD1 10q21.1 / GABRA1 5q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;10)(q34;q21) CISD1/GABRA1

External links

Nomenclature
HGNC (Hugo)CISD1   30880
Cards
Entrez_Gene (NCBI)CISD1  55847  CDGSH iron sulfur domain 1
AliasesC10orf70; MDS029; ZCD1; mitoNEET
GeneCards (Weizmann)CISD1
Ensembl hg19 (Hinxton)ENSG00000122873 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122873 [Gene_View]  ENSG00000122873 [Sequence]  chr10:58269102-58289259 [Contig_View]  CISD1 [Vega]
ICGC DataPortalENSG00000122873
TCGA cBioPortalCISD1
AceView (NCBI)CISD1
Genatlas (Paris)CISD1
WikiGenes55847
SOURCE (Princeton)CISD1
Genetics Home Reference (NIH)CISD1
Genomic and cartography
GoldenPath hg38 (UCSC)CISD1  -     chr10:58269102-58289259 +  10q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CISD1  -     10q21.1   [Description]    (hg19-Feb_2009)
EnsemblCISD1 - 10q21.1 [CytoView hg19]  CISD1 - 10q21.1 [CytoView hg38]
Mapping of homologs : NCBICISD1 [Mapview hg19]  CISD1 [Mapview hg38]
OMIM611932   
Gene and transcription
Genbank (Entrez)AF220049 AI025360 AK312017 AY960578 BC005962
RefSeq transcript (Entrez)NM_018464
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CISD1
Cluster EST : UnigeneHs.370102 [ NCBI ]
CGAP (NCI)Hs.370102
Alternative Splicing GalleryENSG00000122873
Gene ExpressionCISD1 [ NCBI-GEO ]   CISD1 [ EBI - ARRAY_EXPRESS ]   CISD1 [ SEEK ]   CISD1 [ MEM ]
Gene Expression Viewer (FireBrowse)CISD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55847
GTEX Portal (Tissue expression)CISD1
Human Protein AtlasENSG00000122873-CISD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZ45   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZ45  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZ45
Splice isoforms : SwissVarQ9NZ45
PhosPhoSitePlusQ9NZ45
Domains : Interpro (EBI)FeS-contain_CDGSH-typ    FeS-contain_mitoNEET_N   
Domain families : Pfam (Sanger)MitoNEET_N (PF10660)    zf-CDGSH (PF09360)   
Domain families : Pfam (NCBI)pfam10660    pfam09360   
Domain families : Smart (EMBL)ZnF_CDGSH (SM00704)  
Conserved Domain (NCBI)CISD1
DMDM Disease mutations55847
Blocks (Seattle)CISD1
PDB (SRS)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
PDB (PDBSum)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
PDB (IMB)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
PDB (RSDB)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
Structural Biology KnowledgeBase2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
SCOP (Structural Classification of Proteins)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
CATH (Classification of proteins structures)2QD0    2QH7    2R13    3EW0    3LPQ    3REE    4EZF    4F1E    4F28    4F2C   
SuperfamilyQ9NZ45
Human Protein Atlas [tissue]ENSG00000122873-CISD1 [tissue]
Peptide AtlasQ9NZ45
HPRD12587
IPIIPI00020510   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZ45
IntAct (EBI)Q9NZ45
FunCoupENSG00000122873
BioGRIDCISD1
STRING (EMBL)CISD1
ZODIACCISD1
Ontologies - Pathways
QuickGOQ9NZ45
Ontology : AmiGOmitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  integral component of membrane  identical protein binding  regulation of cellular respiration  metal ion binding  2 iron, 2 sulfur cluster binding  
Ontology : EGO-EBImitochondrion  mitochondrion  mitochondrion  mitochondrial outer membrane  integral component of membrane  identical protein binding  regulation of cellular respiration  metal ion binding  2 iron, 2 sulfur cluster binding  
NDEx NetworkCISD1
Atlas of Cancer Signalling NetworkCISD1
Wikipedia pathwaysCISD1
Orthology - Evolution
OrthoDB55847
GeneTree (enSembl)ENSG00000122873
Phylogenetic Trees/Animal Genes : TreeFamCISD1
HOVERGENQ9NZ45
HOGENOMQ9NZ45
Homologs : HomoloGeneCISD1
Homology/Alignments : Family Browser (UCSC)CISD1
Gene fusions - Rearrangements
Fusion : MitelmanCISD1/GABRA1 [10q21.1/5q34]  
Fusion PortalCISD1 10q21.1 GABRA1 5q34 LUSC
Fusion : QuiverCISD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCISD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CISD1
dbVarCISD1
ClinVarCISD1
1000_GenomesCISD1 
Exome Variant ServerCISD1
ExAC (Exome Aggregation Consortium)ENSG00000122873
GNOMAD BrowserENSG00000122873
Varsome BrowserCISD1
Genetic variants : HAPMAP55847
Genomic Variants (DGV)CISD1 [DGVbeta]
DECIPHERCISD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCISD1 
Mutations
ICGC Data PortalCISD1 
TCGA Data PortalCISD1 
Broad Tumor PortalCISD1
OASIS PortalCISD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCISD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCISD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CISD1
DgiDB (Drug Gene Interaction Database)CISD1
DoCM (Curated mutations)CISD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CISD1 (select a term)
intoGenCISD1
Cancer3DCISD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611932   
Orphanet
DisGeNETCISD1
MedgenCISD1
Genetic Testing Registry CISD1
NextProtQ9NZ45 [Medical]
TSGene55847
GENETestsCISD1
Target ValidationCISD1
Huge Navigator CISD1 [HugePedia]
snp3D : Map Gene to Disease55847
BioCentury BCIQCISD1
ClinGenCISD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55847
Chemical/Pharm GKB GenePA162382289
Clinical trialCISD1
Miscellaneous
canSAR (ICR)CISD1 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCISD1
EVEXCISD1
GoPubMedCISD1
iHOPCISD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:58:29 CET 2018
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