CISH (cytokine inducible SH2 containing protein)

2007-02-01  

Identity

HGNC
CISH
LOCATION
3p21.2
LOCUSID
1154
ALIAS
BACTS2,CIS,CIS-1,G18,SOCS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1154
MIM: 602441
HGNC: 1984
Ensembl: ENSG00000114737

Variants:

dbSNP: 1154
ClinVar: 1154
TCGA: ENSG00000114737
COSMIC: CISH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114737ENST00000348721Q9NSE2
ENSG00000114737ENST00000443053Q9NSE2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Growth hormone receptor signalingREACTOMER-HSA-982772

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
195926572009MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge.60
204843912010CISH and susceptibility to infectious diseases.47
204843912010CISH and susceptibility to infectious diseases.47
213833822011Programmed death 1 and cytokine inducible SH2-containing protein dependent expansion of regulatory T cells upon stimulation With Mycobacterium tuberculosis.30
184205852008RACK1 and CIS mediate the degradation of BimEL in cancer cells.26
281886732017Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy.20
195954072009RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules.18
166848152006A complex interaction pattern of CIS and SOCS2 with the leptin receptor.16
251044392014Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.15

Citation

Dessen P

CISH (cytokine inducible SH2 containing protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45611/cish