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CISH (cytokine inducible SH2 containing protein)

Identity

Alias_namescytokine inducible SH2-containing protein
Alias_symbol (synonym)CIS
G18
CIS-1
SOCS
Other aliasBACTS2
HGNC (Hugo) CISH
LocusID (NCBI) 1154
Atlas_Id 45611
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 50606454 and ends at 50611831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AMMECR1 (Xq23) / CISH (3p21.2)CISH (3p21.2) / CISH (3p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CISH   1984
Cards
Entrez_Gene (NCBI)CISH  1154  cytokine inducible SH2 containing protein
AliasesBACTS2; CIS; CIS-1; G18; 
SOCS
GeneCards (Weizmann)CISH
Ensembl hg19 (Hinxton)ENSG00000114737 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114737 [Gene_View]  chr3:50606454-50611831 [Contig_View]  CISH [Vega]
ICGC DataPortalENSG00000114737
TCGA cBioPortalCISH
AceView (NCBI)CISH
Genatlas (Paris)CISH
WikiGenes1154
SOURCE (Princeton)CISH
Genetics Home Reference (NIH)CISH
Genomic and cartography
GoldenPath hg38 (UCSC)CISH  -     chr3:50606454-50611831 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CISH  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblCISH - 3p21.2 [CytoView hg19]  CISH - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBICISH [Mapview hg19]  CISH [Mapview hg38]
OMIM602441   607948   611162   614383   
Gene and transcription
Genbank (Entrez)AF035947 AF132297 AK313850 BC031590 BC064354
RefSeq transcript (Entrez)NM_013324 NM_145071
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CISH
Cluster EST : UnigeneHs.655334 [ NCBI ]
CGAP (NCI)Hs.655334
Alternative Splicing GalleryENSG00000114737
Gene ExpressionCISH [ NCBI-GEO ]   CISH [ EBI - ARRAY_EXPRESS ]   CISH [ SEEK ]   CISH [ MEM ]
Gene Expression Viewer (FireBrowse)CISH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1154
GTEX Portal (Tissue expression)CISH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSE2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSE2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSE2
Splice isoforms : SwissVarQ9NSE2
PhosPhoSitePlusQ9NSE2
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SOCS (PS50225)   
Domains : Interpro (EBI)CIS    SH2    SOCS_box   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)CISH
DMDM Disease mutations1154
Blocks (Seattle)CISH
SuperfamilyQ9NSE2
Human Protein AtlasENSG00000114737
Peptide AtlasQ9NSE2
HPRD03897
IPIIPI00017281   IPI00221337   IPI00412214   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSE2
IntAct (EBI)Q9NSE2
FunCoupENSG00000114737
BioGRIDCISH
STRING (EMBL)CISH
ZODIACCISH
Ontologies - Pathways
QuickGOQ9NSE2
Ontology : AmiGOregulation of cell growth  molecular_function  protein kinase inhibitor activity  protein binding  cellular_component  cytoplasm  cytosol  plasma membrane  negative regulation of protein kinase activity  protein kinase C-activating G-protein coupled receptor signaling pathway  protein ubiquitination  cytokine-mediated signaling pathway  intracellular signal transduction  negative regulation of JAK-STAT cascade  negative regulation of insulin receptor signaling pathway  
Ontology : EGO-EBIregulation of cell growth  molecular_function  protein kinase inhibitor activity  protein binding  cellular_component  cytoplasm  cytosol  plasma membrane  negative regulation of protein kinase activity  protein kinase C-activating G-protein coupled receptor signaling pathway  protein ubiquitination  cytokine-mediated signaling pathway  intracellular signal transduction  negative regulation of JAK-STAT cascade  negative regulation of insulin receptor signaling pathway  
Pathways : KEGGJak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkCISH
Atlas of Cancer Signalling NetworkCISH
Wikipedia pathwaysCISH
Orthology - Evolution
OrthoDB1154
GeneTree (enSembl)ENSG00000114737
Phylogenetic Trees/Animal Genes : TreeFamCISH
HOVERGENQ9NSE2
HOGENOMQ9NSE2
Homologs : HomoloGeneCISH
Homology/Alignments : Family Browser (UCSC)CISH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCISH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CISH
dbVarCISH
ClinVarCISH
1000_GenomesCISH 
Exome Variant ServerCISH
ExAC (Exome Aggregation Consortium)CISH (select the gene name)
Genetic variants : HAPMAP1154
Genomic Variants (DGV)CISH [DGVbeta]
DECIPHERCISH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCISH 
Mutations
ICGC Data PortalCISH 
TCGA Data PortalCISH 
Broad Tumor PortalCISH
OASIS PortalCISH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCISH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCISH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch CISH
DgiDB (Drug Gene Interaction Database)CISH
DoCM (Curated mutations)CISH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CISH (select a term)
intoGenCISH
Cancer3DCISH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602441    607948    611162    614383   
Orphanet
MedgenCISH
Genetic Testing Registry CISH
NextProtQ9NSE2 [Medical]
TSGene1154
GENETestsCISH
Target ValidationCISH
Huge Navigator CISH [HugePedia]
snp3D : Map Gene to Disease1154
BioCentury BCIQCISH
ClinGenCISH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1154
Chemical/Pharm GKB GenePA26521
Clinical trialCISH
Miscellaneous
canSAR (ICR)CISH (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCISH
EVEXCISH
GoPubMedCISH
iHOPCISH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:31 CEST 2017

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