Identity
HGNC
LOCATION
12q24.23
LOCUSID
ALIAS
CITK,CRIK,MCPH17,STK21
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11113
MIM: 605629
HGNC: 1985
Ensembl: ENSG00000122966
Variants:
dbSNP: 11113
ClinVar: 11113
TCGA: ENSG00000122966
COSMIC: CIT
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| RHO GTPase Effectors | REACTOME | R-HSA-195258 |
| RHO GTPases activate CIT | REACTOME | R-HSA-5625900 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37801613 | 2023 | Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase. | 2 |
| 37801613 | 2023 | Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase. | 2 |
| 31972359 | 2020 | Down-regulation of CIT can inhibit the growth of human bladder cancer cells. | 9 |
| 32705161 | 2020 | Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer. | 11 |
| 31972359 | 2020 | Down-regulation of CIT can inhibit the growth of human bladder cancer cells. | 9 |
| 32705161 | 2020 | Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer. | 11 |
| 30565087 | 2019 | Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism. | 9 |
| 30940634 | 2019 | Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. | 10 |
| 30565087 | 2019 | Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism. | 9 |
| 30940634 | 2019 | Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. | 10 |
| 29921697 | 2018 | Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence. | 17 |
| 29921697 | 2018 | Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence. | 17 |
| 26586574 | 2016 | Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation. | 26 |
| 27009191 | 2016 | Cross-regulation between Aurora B and Citron kinase controls midbody architecture in cytokinesis. | 26 |
| 27453578 | 2016 | Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly. | 45 |
Citation
Dessen P
CIT (citron rho-interacting serine/threonine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43214/cit
