CKAP4 (cytoskeleton associated protein 4)

2003-02-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
CLIMP-63,CLIMP63,ERGIC-63,p63
FUSION GENES

Other Information

Locus ID:

NCBI: 10970
MIM: 618595
HGNC: 16991
Ensembl: ENSG00000136026

Variants:

dbSNP: 10970
ClinVar: 10970
TCGA: ENSG00000136026
COSMIC: CKAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136026ENST00000378026Q07065
ENSG00000136026ENST00000378026A0A024RBH2
ENSG00000136026ENST00000553039F8VVU0

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Surfactant metabolismREACTOMER-HSA-5683826
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211112372010Mechanisms determining the morphology of the peripheral ER.167
208088872010Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.92
220569552012p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.80
170305142006CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients.42
157032172005Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules.41
182966952008Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method.40
231081562013p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.32
273220592016CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.30
191448242009Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.26
129130032003Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4).21

Citation

Dessen P

CKAP4 (cytoskeleton associated protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40088/ckap4