Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CKAP5 (cytoskeleton associated protein 5)

Identity

Alias (NCBI)CHTOG
MSPS
TOG
TOGp
ch-TOG
HGNC (Hugo) CKAP5
HGNC Alias symbch-TOG
KIAA0097
TOG
TOGp
LocusID (NCBI) 9793
Atlas_Id 46139
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46743534 and ends at 46846308 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAZ2A (12q13.3) / CKAP5 (11p11.2)CAD (2p23.3) / CKAP5 (11p11.2)CKAP5 (11p11.2) / STATH (4q13.3)
CKAP5 (11p11.2) / TMEM135 (11q14.2)CKAP5 (11p11.2) / VMP1 (17q23.1)FRMD5 (15q15.3) / CKAP5 (11p11.2)
PTPN12 (7q11.23) / CKAP5 (11p11.2)ZNF43 (19p12) / CKAP5 (11p11.2)CKAP5 11p11.2 / TMEM135 11q14.2
CKAP5 11p11.2 / VMP1 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(p11;q14) CKAP5/TMEM135
t(11;17)(p11;q23) CKAP5/VMP1


External links

Nomenclature
HGNC (Hugo)CKAP5   28959
Cards
Entrez_Gene (NCBI)CKAP5    cytoskeleton associated protein 5
AliasesCHTOG; MSPS; TOG; TOGp; 
ch-TOG
GeneCards (Weizmann)CKAP5
Ensembl hg19 (Hinxton)ENSG00000175216 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175216 [Gene_View]  ENSG00000175216 [Sequence]  chr11:46743534-46846308 [Contig_View]  CKAP5 [Vega]
ICGC DataPortalENSG00000175216
TCGA cBioPortalCKAP5
AceView (NCBI)CKAP5
Genatlas (Paris)CKAP5
SOURCE (Princeton)CKAP5
Genetics Home Reference (NIH)CKAP5
Genomic and cartography
GoldenPath hg38 (UCSC)CKAP5  -     chr11:46743534-46846308 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CKAP5  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathCKAP5 - 11p11.2 [CytoView hg19]  CKAP5 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000175216
genome Data Viewer NCBICKAP5 [Mapview hg19]  
OMIM611142   
Gene and transcription
Genbank (Entrez)AW504660 BC017856 BC035554 BC070136 BC111043
RefSeq transcript (Entrez)NM_001008938 NM_014756
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CKAP5
Alternative Splicing GalleryENSG00000175216
Gene ExpressionCKAP5 [ NCBI-GEO ]   CKAP5 [ EBI - ARRAY_EXPRESS ]   CKAP5 [ SEEK ]   CKAP5 [ MEM ]
Gene Expression Viewer (FireBrowse)CKAP5 [ Firebrowse - Broad ]
GenevisibleExpression of CKAP5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9793
GTEX Portal (Tissue expression)CKAP5
Human Protein AtlasENSG00000175216-CKAP5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14008   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14008  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14008
Splice isoforms : SwissVarQ14008
PhosPhoSitePlusQ14008
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    CLASP_N_dom    HEAT_type_2    TOG   
Domain families : Pfam (Sanger)CLASP_N (PF12348)   
Domain families : Pfam (NCBI)pfam12348   
Domain families : Smart (EMBL)TOG (SM01349)  
Conserved Domain (NCBI)CKAP5
Blocks (Seattle)CKAP5
PDB (RSDB)4QMI    4QMJ   
PDB Europe4QMI    4QMJ   
PDB (PDBSum)4QMI    4QMJ   
PDB (IMB)4QMI    4QMJ   
Structural Biology KnowledgeBase4QMI    4QMJ   
SCOP (Structural Classification of Proteins)4QMI    4QMJ   
CATH (Classification of proteins structures)4QMI    4QMJ   
SuperfamilyQ14008
Human Protein Atlas [tissue]ENSG00000175216-CKAP5 [tissue]
Peptide AtlasQ14008
HPRD10830
IPIIPI00028275   IPI00472887   IPI00921422   IPI00749072   IPI00983532   IPI00975590   IPI00976169   
Protein Interaction databases
DIP (DOE-UCLA)Q14008
IntAct (EBI)Q14008
BioGRIDCKAP5
STRING (EMBL)CKAP5
ZODIACCKAP5
Ontologies - Pathways
QuickGOQ14008
Ontology : AmiGOG2/M transition of mitotic cell cycle  kinetochore  kinetochore  condensed chromosome kinetochore  spindle pole  spindle pole  gamma-tubulin complex  protein binding  nucleolus  cytoplasm  centrosome  centrosome  cytosol  plasma membrane  microtubule depolymerization  spindle organization  mitotic spindle organization  centrosome cycle  microtubule binding  microtubule binding  regulation of G2/M transition of mitotic cell cycle  microtubule cytoskeleton  membrane  establishment or maintenance of microtubule cytoskeleton polarity  establishment or maintenance of microtubule cytoskeleton polarity  protein-containing complex  microtubule plus-end  microtubule plus-end  ribonucleoprotein complex binding  cadherin binding  microtubule polymerization  microtubule polymerization  RNA transport  centrosome duplication  cell division  microtubule plus end polymerase  positive regulation of microtubule nucleation  ciliary basal body-plasma membrane docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  kinetochore  kinetochore  condensed chromosome kinetochore  spindle pole  spindle pole  gamma-tubulin complex  protein binding  nucleolus  cytoplasm  centrosome  centrosome  cytosol  plasma membrane  microtubule depolymerization  spindle organization  mitotic spindle organization  centrosome cycle  microtubule binding  microtubule binding  regulation of G2/M transition of mitotic cell cycle  microtubule cytoskeleton  membrane  establishment or maintenance of microtubule cytoskeleton polarity  establishment or maintenance of microtubule cytoskeleton polarity  protein-containing complex  microtubule plus-end  microtubule plus-end  ribonucleoprotein complex binding  cadherin binding  microtubule polymerization  microtubule polymerization  RNA transport  centrosome duplication  cell division  microtubule plus end polymerase  positive regulation of microtubule nucleation  ciliary basal body-plasma membrane docking  
NDEx NetworkCKAP5
Atlas of Cancer Signalling NetworkCKAP5
Wikipedia pathwaysCKAP5
Orthology - Evolution
OrthoDB9793
GeneTree (enSembl)ENSG00000175216
Phylogenetic Trees/Animal Genes : TreeFamCKAP5
HOGENOMQ14008
Homologs : HomoloGeneCKAP5
Homology/Alignments : Family Browser (UCSC)CKAP5
Gene fusions - Rearrangements
Fusion : MitelmanCKAP5/TMEM135 [11p11.2/11q14.2]  
Fusion : MitelmanCKAP5/VMP1 [11p11.2/17q23.1]  
Fusion PortalCKAP5 11p11.2 TMEM135 11q14.2 LGG
Fusion PortalCKAP5 11p11.2 VMP1 17q23.1 BRCA
Fusion : QuiverCKAP5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCKAP5 [hg38]
dbVarCKAP5
ClinVarCKAP5
MonarchCKAP5
1000_GenomesCKAP5 
Exome Variant ServerCKAP5
GNOMAD BrowserENSG00000175216
Varsome BrowserCKAP5
Genomic Variants (DGV)CKAP5 [DGVbeta]
DECIPHERCKAP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCKAP5 
Mutations
ICGC Data PortalCKAP5 
TCGA Data PortalCKAP5 
Broad Tumor PortalCKAP5
OASIS PortalCKAP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCKAP5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCKAP5
Mutations and Diseases : HGMDCKAP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CKAP5
DgiDB (Drug Gene Interaction Database)CKAP5
DoCM (Curated mutations)CKAP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CKAP5 (select a term)
intoGenCKAP5
Cancer3DCKAP5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611142   
Orphanet
DisGeNETCKAP5
MedgenCKAP5
Genetic Testing Registry CKAP5
NextProtQ14008 [Medical]
GENETestsCKAP5
Target ValidationCKAP5
Huge Navigator CKAP5 [HugePedia]
ClinGenCKAP5
Clinical trials, drugs, therapy
MyCancerGenomeCKAP5
Protein Interactions : CTD
Pharm GKB GenePA142672107
PharosQ14008
Clinical trialCKAP5
Miscellaneous
canSAR (ICR)CKAP5 (select the gene name)
HarmonizomeCKAP5
DataMed IndexCKAP5
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCKAP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:10:16 CET 2021

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