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CLASP1 (cytoplasmic linker associated protein 1)

Identity

Alias_symbol (synonym)KIAA0622
MAST1
Other alias
HGNC (Hugo) CLASP1
LocusID (NCBI) 23332
Atlas_Id 55998
Location 2q14.2  [Link to chromosome band 2q14]
Location_base_pair Starts at 121337776 and ends at 121649476 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLASP1 (2q14.2) / C1orf95 (1q42.12)CLASP1 (2q14.2) / HSD17B11 (4q22.1)CLASP1 (2q14.2) / NR4A1 (12q13.13)
CLASP1 (2q14.2) / ST8SIA4 (5q21.1)CLASP1 (2q14.2) / UPF2 (10p14)CSDE1 (1p13.2) / CLASP1 (2q14.2)
MACF1 (1p34.3) / CLASP1 (2q14.2)RPS24 (10q22.3) / CLASP1 (2q14.2)TFCP2L1 (2q14.2) / CLASP1 (2q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLASP1   17088
Cards
Entrez_Gene (NCBI)CLASP1  23332  cytoplasmic linker associated protein 1
AliasesMAST1
GeneCards (Weizmann)CLASP1
Ensembl hg19 (Hinxton)ENSG00000074054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074054 [Gene_View]  chr2:121337776-121649476 [Contig_View]  CLASP1 [Vega]
ICGC DataPortalENSG00000074054
TCGA cBioPortalCLASP1
AceView (NCBI)CLASP1
Genatlas (Paris)CLASP1
WikiGenes23332
SOURCE (Princeton)CLASP1
Genetics Home Reference (NIH)CLASP1
Genomic and cartography
GoldenPath hg38 (UCSC)CLASP1  -     chr2:121337776-121649476 -  2q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLASP1  -     2q14.2   [Description]    (hg19-Feb_2009)
EnsemblCLASP1 - 2q14.2 [CytoView hg19]  CLASP1 - 2q14.2 [CytoView hg38]
Mapping of homologs : NCBICLASP1 [Mapview hg19]  CLASP1 [Mapview hg38]
OMIM605852   
Gene and transcription
Genbank (Entrez)AB014522 AF347693 AJ288057 AK074338 AK091140
RefSeq transcript (Entrez)NM_001142273 NM_001142274 NM_001207051 NM_015282
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLASP1
Cluster EST : UnigeneHs.708183 [ NCBI ]
CGAP (NCI)Hs.708183
Alternative Splicing GalleryENSG00000074054
Gene ExpressionCLASP1 [ NCBI-GEO ]   CLASP1 [ EBI - ARRAY_EXPRESS ]   CLASP1 [ SEEK ]   CLASP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLASP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23332
GTEX Portal (Tissue expression)CLASP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z460   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z460  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z460
Splice isoforms : SwissVarQ7Z460
PhosPhoSitePlusQ7Z460
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    CLASP_1    CLASP_N_dom    HEAT_type_2    TOG   
Domain families : Pfam (Sanger)CLASP_N (PF12348)   
Domain families : Pfam (NCBI)pfam12348   
Domain families : Smart (EMBL)TOG (SM01349)  
Conserved Domain (NCBI)CLASP1
DMDM Disease mutations23332
Blocks (Seattle)CLASP1
PDB (SRS)4K92   
PDB (PDBSum)4K92   
PDB (IMB)4K92   
PDB (RSDB)4K92   
Structural Biology KnowledgeBase4K92   
SCOP (Structural Classification of Proteins)4K92   
CATH (Classification of proteins structures)4K92   
SuperfamilyQ7Z460
Human Protein AtlasENSG00000074054
Peptide AtlasQ7Z460
HPRD09322
IPIIPI00396279   IPI00744551   IPI00828013   IPI01015555   IPI01009400   IPI01024943   IPI00930129   IPI00915353   IPI01018173   IPI00927083   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z460
IntAct (EBI)Q7Z460
FunCoupENSG00000074054
BioGRIDCLASP1
STRING (EMBL)CLASP1
ZODIACCLASP1
Ontologies - Pathways
QuickGOQ7Z460
Ontology : AmiGOG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  microtubule cytoskeleton organization  kinetochore  condensed chromosome kinetochore  microtubule bundle formation  dystroglycan binding  protein binding  Golgi apparatus  centrosome  kinetochore microtubule  cytosol  spindle microtubule  cytoplasmic microtubule  focal adhesion  cell cortex  vesicle targeting  microtubule nucleation  negative regulation of microtubule depolymerization  negative regulation of microtubule depolymerization  Golgi organization  mitotic spindle organization  sister chromatid cohesion  establishment or maintenance of cell polarity  microtubule binding  microtubule binding  exit from mitosis  regulation of gastrulation  positive regulation of epithelial cell migration  regulation of epithelial to mesenchymal transition  membrane  astral microtubule organization  cortical microtubule cytoskeleton  microtubule organizing center organization  negative regulation of microtubule polymerization or depolymerization  positive regulation of microtubule polymerization  centrosomal corona  microtubule anchoring  microtubule plus-end  establishment of mitotic spindle localization  kinetochore binding  basal cortex  positive regulation of exocytosis  microtubule plus-end binding  establishment of spindle orientation  establishment of spindle orientation  establishment of spindle orientation  cell division  negative regulation of stress fiber assembly  regulation of focal adhesion assembly  extracellular exosome  regulation of microtubule cytoskeleton organization  positive regulation of extracellular matrix disassembly  establishment of epithelial cell polarity  mitotic spindle assembly  ciliary basal body docking  negative regulation of wound healing, spreading of epidermal cells  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  microtubule cytoskeleton organization  kinetochore  condensed chromosome kinetochore  microtubule bundle formation  dystroglycan binding  protein binding  Golgi apparatus  centrosome  kinetochore microtubule  cytosol  spindle microtubule  cytoplasmic microtubule  focal adhesion  cell cortex  vesicle targeting  microtubule nucleation  negative regulation of microtubule depolymerization  negative regulation of microtubule depolymerization  Golgi organization  mitotic spindle organization  sister chromatid cohesion  establishment or maintenance of cell polarity  microtubule binding  microtubule binding  exit from mitosis  regulation of gastrulation  positive regulation of epithelial cell migration  regulation of epithelial to mesenchymal transition  membrane  astral microtubule organization  cortical microtubule cytoskeleton  microtubule organizing center organization  negative regulation of microtubule polymerization or depolymerization  positive regulation of microtubule polymerization  centrosomal corona  microtubule anchoring  microtubule plus-end  establishment of mitotic spindle localization  kinetochore binding  basal cortex  positive regulation of exocytosis  microtubule plus-end binding  establishment of spindle orientation  establishment of spindle orientation  establishment of spindle orientation  cell division  negative regulation of stress fiber assembly  regulation of focal adhesion assembly  extracellular exosome  regulation of microtubule cytoskeleton organization  positive regulation of extracellular matrix disassembly  establishment of epithelial cell polarity  mitotic spindle assembly  ciliary basal body docking  negative regulation of wound healing, spreading of epidermal cells  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
NDEx NetworkCLASP1
Atlas of Cancer Signalling NetworkCLASP1
Wikipedia pathwaysCLASP1
Orthology - Evolution
OrthoDB23332
GeneTree (enSembl)ENSG00000074054
Phylogenetic Trees/Animal Genes : TreeFamCLASP1
HOVERGENQ7Z460
HOGENOMQ7Z460
Homologs : HomoloGeneCLASP1
Homology/Alignments : Family Browser (UCSC)CLASP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLASP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLASP1
dbVarCLASP1
ClinVarCLASP1
1000_GenomesCLASP1 
Exome Variant ServerCLASP1
ExAC (Exome Aggregation Consortium)CLASP1 (select the gene name)
Genetic variants : HAPMAP23332
Genomic Variants (DGV)CLASP1 [DGVbeta]
DECIPHERCLASP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLASP1 
Mutations
ICGC Data PortalCLASP1 
TCGA Data PortalCLASP1 
Broad Tumor PortalCLASP1
OASIS PortalCLASP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLASP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLASP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLASP1
DgiDB (Drug Gene Interaction Database)CLASP1
DoCM (Curated mutations)CLASP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLASP1 (select a term)
intoGenCLASP1
Cancer3DCLASP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605852   
Orphanet
MedgenCLASP1
Genetic Testing Registry CLASP1
NextProtQ7Z460 [Medical]
TSGene23332
GENETestsCLASP1
Target ValidationCLASP1
Huge Navigator CLASP1 [HugePedia]
snp3D : Map Gene to Disease23332
BioCentury BCIQCLASP1
ClinGenCLASP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23332
Chemical/Pharm GKB GenePA38436
Clinical trialCLASP1
Miscellaneous
canSAR (ICR)CLASP1 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLASP1
EVEXCLASP1
GoPubMedCLASP1
iHOPCLASP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:28:34 CEST 2017

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