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CLASP1 (cytoplasmic linker associated protein 1)

Identity

Alias (NCBI)MAST1
HGNC (Hugo) CLASP1
HGNC Alias symbKIAA0622
MAST1
HGNC Alias namemultiple asters 1
 CLIP-associating protein 1
LocusID (NCBI) 23332
Atlas_Id 55998
Location 2q14.2  [Link to chromosome band 2q14]
Location_base_pair Starts at 121337776 and ends at 121649462 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLASP1 (2q14.2) / C1orf95 (1q42.12)CLASP1 (2q14.2) / HSD17B11 (4q22.1)CLASP1 (2q14.2) / NR4A1 (12q13.13)
CLASP1 (2q14.2) / ST8SIA4 (5q21.1)CLASP1 (2q14.2) / UPF2 (10p14)CSDE1 (1p13.2) / CLASP1 (2q14.2)
MACF1 (1p34.3) / CLASP1 (2q14.2)RPS24 (10q22.3) / CLASP1 (2q14.2)TFCP2L1 (2q14.2) / CLASP1 (2q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLASP1   17088
Cards
Entrez_Gene (NCBI)CLASP1    cytoplasmic linker associated protein 1
AliasesMAST1
GeneCards (Weizmann)CLASP1
Ensembl hg19 (Hinxton)ENSG00000074054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074054 [Gene_View]  ENSG00000074054 [Sequence]  chr2:121337776-121649462 [Contig_View]  CLASP1 [Vega]
ICGC DataPortalENSG00000074054
TCGA cBioPortalCLASP1
AceView (NCBI)CLASP1
Genatlas (Paris)CLASP1
SOURCE (Princeton)CLASP1
Genetics Home Reference (NIH)CLASP1
Genomic and cartography
GoldenPath hg38 (UCSC)CLASP1  -     chr2:121337776-121649462 -  2q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLASP1  -     2q14.2   [Description]    (hg19-Feb_2009)
GoldenPathCLASP1 - 2q14.2 [CytoView hg19]  CLASP1 - 2q14.2 [CytoView hg38]
ImmunoBaseENSG00000074054
Genome Data Viewer NCBICLASP1 [Mapview hg19]  
OMIM605852   
Gene and transcription
Genbank (Entrez)AB014522 AF347693 AJ288057 AK074338 AK091140
RefSeq transcript (Entrez)NM_001142273 NM_001142274 NM_001207051 NM_001378003 NM_001378004 NM_001378005 NM_015282
Consensus coding sequences : CCDS (NCBI)CLASP1
Gene ExpressionCLASP1 [ NCBI-GEO ]   CLASP1 [ EBI - ARRAY_EXPRESS ]   CLASP1 [ SEEK ]   CLASP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLASP1 [ Firebrowse - Broad ]
GenevisibleExpression of CLASP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23332
GTEX Portal (Tissue expression)CLASP1
Human Protein AtlasENSG00000074054-CLASP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z460   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z460  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z460
PhosPhoSitePlusQ7Z460
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    CLASP_1    CLASP_N_dom    HEAT_type_2    TOG   
Domain families : Pfam (Sanger)CLASP_N (PF12348)   
Domain families : Pfam (NCBI)pfam12348   
Domain families : Smart (EMBL)TOG (SM01349)  
Conserved Domain (NCBI)CLASP1
PDB (RSDB)4K92    6MQ5    6MQ7   
PDB Europe4K92    6MQ5    6MQ7   
PDB (PDBSum)4K92    6MQ5    6MQ7   
PDB (IMB)4K92    6MQ5    6MQ7   
Structural Biology KnowledgeBase4K92    6MQ5    6MQ7   
SCOP (Structural Classification of Proteins)4K92    6MQ5    6MQ7   
CATH (Classification of proteins structures)4K92    6MQ5    6MQ7   
SuperfamilyQ7Z460
AlphaFold pdb e-kbQ7Z460   
Human Protein Atlas [tissue]ENSG00000074054-CLASP1 [tissue]
HPRD09322
Protein Interaction databases
DIP (DOE-UCLA)Q7Z460
IntAct (EBI)Q7Z460
BioGRIDCLASP1
STRING (EMBL)CLASP1
ZODIACCLASP1
Ontologies - Pathways
QuickGOQ7Z460
Ontology : AmiGOG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  microtubule cytoskeleton organization  microtubule cytoskeleton organization  kinetochore  kinetochore  microtubule bundle formation  dystroglycan binding  protein binding  Golgi apparatus  centrosome  microtubule organizing center  kinetochore microtubule  cytosol  spindle microtubule  spindle microtubule  cytoplasmic microtubule  cytoplasmic microtubule  focal adhesion  cell cortex  vesicle targeting  microtubule nucleation  negative regulation of microtubule depolymerization  negative regulation of microtubule depolymerization  Golgi organization  mitotic spindle organization  mitotic spindle organization  establishment or maintenance of cell polarity  microtubule binding  microtubule binding  microtubule binding  regulation of G2/M transition of mitotic cell cycle  exit from mitosis  regulation of gastrulation  positive regulation of epithelial cell migration  regulation of epithelial to mesenchymal transition  membrane  astral microtubule organization  cortical microtubule cytoskeleton  microtubule organizing center organization  negative regulation of microtubule polymerization or depolymerization  positive regulation of microtubule polymerization  centrosomal corona  microtubule anchoring  microtubule plus-end  establishment of mitotic spindle localization  establishment of mitotic spindle localization  kinetochore binding  kinetochore binding  basal cortex  basal cortex  positive regulation of exocytosis  microtubule plus-end binding  establishment of spindle orientation  establishment of spindle orientation  establishment of spindle orientation  cell division  negative regulation of stress fiber assembly  regulation of focal adhesion assembly  regulation of microtubule cytoskeleton organization  mitotic spindle  positive regulation of extracellular matrix disassembly  establishment of epithelial cell polarity  mitotic spindle assembly  mitotic spindle assembly  ciliary basal body-plasma membrane docking  negative regulation of wound healing, spreading of epidermal cells  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  microtubule cytoskeleton organization  microtubule cytoskeleton organization  kinetochore  kinetochore  microtubule bundle formation  dystroglycan binding  protein binding  Golgi apparatus  centrosome  microtubule organizing center  kinetochore microtubule  cytosol  spindle microtubule  spindle microtubule  cytoplasmic microtubule  cytoplasmic microtubule  focal adhesion  cell cortex  vesicle targeting  microtubule nucleation  negative regulation of microtubule depolymerization  negative regulation of microtubule depolymerization  Golgi organization  mitotic spindle organization  mitotic spindle organization  establishment or maintenance of cell polarity  microtubule binding  microtubule binding  microtubule binding  regulation of G2/M transition of mitotic cell cycle  exit from mitosis  regulation of gastrulation  positive regulation of epithelial cell migration  regulation of epithelial to mesenchymal transition  membrane  astral microtubule organization  cortical microtubule cytoskeleton  microtubule organizing center organization  negative regulation of microtubule polymerization or depolymerization  positive regulation of microtubule polymerization  centrosomal corona  microtubule anchoring  microtubule plus-end  establishment of mitotic spindle localization  establishment of mitotic spindle localization  kinetochore binding  kinetochore binding  basal cortex  basal cortex  positive regulation of exocytosis  microtubule plus-end binding  establishment of spindle orientation  establishment of spindle orientation  establishment of spindle orientation  cell division  negative regulation of stress fiber assembly  regulation of focal adhesion assembly  regulation of microtubule cytoskeleton organization  mitotic spindle  positive regulation of extracellular matrix disassembly  establishment of epithelial cell polarity  mitotic spindle assembly  mitotic spindle assembly  ciliary basal body-plasma membrane docking  negative regulation of wound healing, spreading of epidermal cells  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
NDEx NetworkCLASP1
Atlas of Cancer Signalling NetworkCLASP1
Wikipedia pathwaysCLASP1
Orthology - Evolution
OrthoDB23332
GeneTree (enSembl)ENSG00000074054
Phylogenetic Trees/Animal Genes : TreeFamCLASP1
Homologs : HomoloGeneCLASP1
Homology/Alignments : Family Browser (UCSC)CLASP1
Gene fusions - Rearrangements
Fusion : QuiverCLASP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLASP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLASP1
dbVarCLASP1
ClinVarCLASP1
MonarchCLASP1
1000_GenomesCLASP1 
Exome Variant ServerCLASP1
GNOMAD BrowserENSG00000074054
Varsome BrowserCLASP1
ACMGCLASP1 variants
VarityQ7Z460
Genomic Variants (DGV)CLASP1 [DGVbeta]
DECIPHERCLASP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLASP1 
Mutations
ICGC Data PortalCLASP1 
TCGA Data PortalCLASP1 
Broad Tumor PortalCLASP1
OASIS PortalCLASP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLASP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLASP1
Mutations and Diseases : HGMDCLASP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLASP1
DgiDB (Drug Gene Interaction Database)CLASP1
DoCM (Curated mutations)CLASP1
CIViC (Clinical Interpretations of Variants in Cancer)CLASP1
Cancer3DCLASP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605852   
Orphanet
DisGeNETCLASP1
MedgenCLASP1
Genetic Testing Registry CLASP1
NextProtQ7Z460 [Medical]
GENETestsCLASP1
Target ValidationCLASP1
Huge Navigator CLASP1 [HugePedia]
ClinGenCLASP1
Clinical trials, drugs, therapy
MyCancerGenomeCLASP1
Protein Interactions : CTDCLASP1
Pharm GKB GenePA38436
PharosQ7Z460
Clinical trialCLASP1
Miscellaneous
canSAR (ICR)CLASP1
HarmonizomeCLASP1
DataMed IndexCLASP1
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLASP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:04:10 CEST 2021

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