CLASP2 (cytoplasmic linker associated protein 2)

2018-07-01  

Identity

HGNC
LOCATION
3p22.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23122
MIM: 605853
HGNC: 17078
Ensembl: ENSG00000163539

Variants:

dbSNP: 23122
ClinVar: 23122
TCGA: ENSG00000163539
COSMIC: CLASP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163539ENST00000313350O75122
ENSG00000163539ENST00000333778E7ENG2
ENSG00000163539ENST00000359576O75122
ENSG00000163539ENST00000399362E7ERI8
ENSG00000163539ENST00000461133E3W994
ENSG00000163539ENST00000468888E7EW49
ENSG00000163539ENST00000475576H7C4M5
ENSG00000163539ENST00000476251H7C4X8
ENSG00000163539ENST00000480013O75122
ENSG00000163539ENST00000480385H7C4I5
ENSG00000163539ENST00000485378D6RBU8
ENSG00000163539ENST00000487200B3KR06
ENSG00000163539ENST00000487553H7C5M8
ENSG00000163539ENST00000496954C9J668
ENSG00000163539ENST00000635664A0A0U1RQI6
ENSG00000163539ENST00000650653J3KR49

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890

References

Pubmed IDYearTitleCitations
156319942005CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.179
197011962009Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.122
217824392011Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.100
159558472005Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.93
192897912009GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment.91
248590052014CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
169145142006Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.41
224678762012Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).39
230455522012Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.39

Citation

Dessen P

CLASP2 (cytoplasmic linker associated protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57586/clasp2