Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CLC (Charcot-Leyden crystal galectin)

Identity

Alias_namesCharcot-Leyden crystal protein
Alias_symbol (synonym)LGALS10
MGC149659
Gal-10
Other aliasGAL10
LGALS10A
LPPL_HUMAN
HGNC (Hugo) CLC
LocusID (NCBI) 1178
Atlas_Id 42926
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39731253 and ends at 39738029 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLC   2014
Cards
Entrez_Gene (NCBI)CLC  1178  Charcot-Leyden crystal galectin
AliasesGAL10; Gal-10; LGALS10; LGALS10A; 
LPPL_HUMAN
GeneCards (Weizmann)CLC
Ensembl hg19 (Hinxton)ENSG00000105205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105205 [Gene_View]  chr19:39731253-39738029 [Contig_View]  CLC [Vega]
ICGC DataPortalENSG00000105205
TCGA cBioPortalCLC
AceView (NCBI)CLC
Genatlas (Paris)CLC
WikiGenes1178
SOURCE (Princeton)CLC
Genetics Home Reference (NIH)CLC
Genomic and cartography
GoldenPath hg38 (UCSC)CLC  -     chr19:39731253-39738029 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLC  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblCLC - 19q13.2 [CytoView hg19]  CLC - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBICLC [Mapview hg19]  CLC [Mapview hg38]
OMIM153310   
Gene and transcription
Genbank (Entrez)AV715261 AV762486 AW292557 BC119711 BC119712
RefSeq transcript (Entrez)NM_001828
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLC
Cluster EST : UnigeneHs.889 [ NCBI ]
CGAP (NCI)Hs.889
Alternative Splicing GalleryENSG00000105205
Gene ExpressionCLC [ NCBI-GEO ]   CLC [ EBI - ARRAY_EXPRESS ]   CLC [ SEEK ]   CLC [ MEM ]
Gene Expression Viewer (FireBrowse)CLC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1178
GTEX Portal (Tissue expression)CLC
Human Protein AtlasENSG00000105205-CLC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05315   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05315  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05315
Splice isoforms : SwissVarQ05315
PhosPhoSitePlusQ05315
Domaine pattern : Prosite (Expaxy)GALECTIN (PS51304)   
Domains : Interpro (EBI)ConA-like_dom    Galectin_10    Galectin_CRD   
Domain families : Pfam (Sanger)Gal-bind_lectin (PF00337)   
Domain families : Pfam (NCBI)pfam00337   
Domain families : Smart (EMBL)Gal-bind_lectin (SM00908)  GLECT (SM00276)  
Conserved Domain (NCBI)CLC
DMDM Disease mutations1178
Blocks (Seattle)CLC
PDB (SRS)1G86    1HDK    1LCL    1QKQ   
PDB (PDBSum)1G86    1HDK    1LCL    1QKQ   
PDB (IMB)1G86    1HDK    1LCL    1QKQ   
PDB (RSDB)1G86    1HDK    1LCL    1QKQ   
Structural Biology KnowledgeBase1G86    1HDK    1LCL    1QKQ   
SCOP (Structural Classification of Proteins)1G86    1HDK    1LCL    1QKQ   
CATH (Classification of proteins structures)1G86    1HDK    1LCL    1QKQ   
SuperfamilyQ05315
Human Protein Atlas [tissue]ENSG00000105205-CLC [tissue]
Peptide AtlasQ05315
HPRD08351
IPIIPI00216071   
Protein Interaction databases
DIP (DOE-UCLA)Q05315
IntAct (EBI)Q05315
FunCoupENSG00000105205
BioGRIDCLC
STRING (EMBL)CLC
ZODIACCLC
Ontologies - Pathways
QuickGOQ05315
Ontology : AmiGOregulation of T cell anergy  regulation of T cell cytokine production  lysophospholipase activity  protein binding  cytosol  multicellular organism development  carbohydrate binding  identical protein binding  regulation of activated T cell proliferation  T cell apoptotic process  cysteine-type endopeptidase activity involved in apoptotic process  
Ontology : EGO-EBIregulation of T cell anergy  regulation of T cell cytokine production  lysophospholipase activity  protein binding  cytosol  multicellular organism development  carbohydrate binding  identical protein binding  regulation of activated T cell proliferation  T cell apoptotic process  cysteine-type endopeptidase activity involved in apoptotic process  
NDEx NetworkCLC
Atlas of Cancer Signalling NetworkCLC
Wikipedia pathwaysCLC
Orthology - Evolution
OrthoDB1178
GeneTree (enSembl)ENSG00000105205
Phylogenetic Trees/Animal Genes : TreeFamCLC
HOVERGENQ05315
HOGENOMQ05315
Homologs : HomoloGeneCLC
Homology/Alignments : Family Browser (UCSC)CLC
Gene fusions - Rearrangements
Tumor Fusion PortalCLC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLC
dbVarCLC
ClinVarCLC
1000_GenomesCLC 
Exome Variant ServerCLC
ExAC (Exome Aggregation Consortium)ENSG00000105205
GNOMAD BrowserENSG00000105205
Genetic variants : HAPMAP1178
Genomic Variants (DGV)CLC [DGVbeta]
DECIPHERCLC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLC 
Mutations
ICGC Data PortalCLC 
TCGA Data PortalCLC 
Broad Tumor PortalCLC
OASIS PortalCLC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLC
DgiDB (Drug Gene Interaction Database)CLC
DoCM (Curated mutations)CLC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLC (select a term)
intoGenCLC
Cancer3DCLC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153310   
Orphanet
DisGeNETCLC
MedgenCLC
Genetic Testing Registry CLC
NextProtQ05315 [Medical]
TSGene1178
GENETestsCLC
Target ValidationCLC
Huge Navigator CLC [HugePedia]
snp3D : Map Gene to Disease1178
BioCentury BCIQCLC
ClinGenCLC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1178
Chemical/Pharm GKB GenePA26541
Clinical trialCLC
Miscellaneous
canSAR (ICR)CLC (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLC
EVEXCLC
GoPubMedCLC
iHOPCLC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:07:57 CET 2017

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