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CLCA2 (chloride channel accessory 2)

Identity

Alias (NCBI)CACC
CACC3
CLCRG2
CaCC-3
HGNC (Hugo) CLCA2
HGNC Alias symbCLCRG2
HGNC Previous namechloride channel, calcium activated, family member 2
 chloride channel regulator 2
LocusID (NCBI) 9635
Atlas_Id 40096
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86424171 and ends at 86456553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RUNX1 (21q22.12) / CLCA2 (1p22.3)SVBP (1p34.2) / CLCA2 (1p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;21)(p22;q22) RUNX1/CLCA2


External links

 

Nomenclature
HGNC (Hugo)CLCA2   2016
Cards
Entrez_Gene (NCBI)CLCA2    chloride channel accessory 2
AliasesCACC; CACC3; CLCRG2; CaCC-3
GeneCards (Weizmann)CLCA2
Ensembl hg19 (Hinxton)ENSG00000137975 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137975 [Gene_View]  ENSG00000137975 [Sequence]  chr1:86424171-86456553 [Contig_View]  CLCA2 [Vega]
ICGC DataPortalENSG00000137975
TCGA cBioPortalCLCA2
AceView (NCBI)CLCA2
Genatlas (Paris)CLCA2
SOURCE (Princeton)CLCA2
Genetics Home Reference (NIH)CLCA2
Genomic and cartography
GoldenPath hg38 (UCSC)CLCA2  -     chr1:86424171-86456553 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCA2  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathCLCA2 - 1p22.3 [CytoView hg19]  CLCA2 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000137975
Genome Data Viewer NCBICLCA2 [Mapview hg19]  
OMIM604003   
Gene and transcription
Genbank (Entrez)AB026833 AF043977 AF127980 AK290348 AK296719
RefSeq transcript (Entrez)NM_006536
Consensus coding sequences : CCDS (NCBI)CLCA2
Gene ExpressionCLCA2 [ NCBI-GEO ]   CLCA2 [ EBI - ARRAY_EXPRESS ]   CLCA2 [ SEEK ]   CLCA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCA2 [ Firebrowse - Broad ]
GenevisibleExpression of CLCA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9635
GTEX Portal (Tissue expression)CLCA2
Human Protein AtlasENSG00000137975-CLCA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQC9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQC9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQC9
PhosPhoSitePlusQ9UQC9
Domaine pattern : Prosite (Expaxy)VWFA (PS50234)   
Domains : Interpro (EBI)CLCA_chordata    CLCA_N    VWF_A    vWFA_dom_sf   
Domain families : Pfam (Sanger)CLCA (PF08434)   
Domain families : Pfam (NCBI)pfam08434   
Domain families : Smart (EMBL)VWA (SM00327)  
Conserved Domain (NCBI)CLCA2
SuperfamilyQ9UQC9
AlphaFold pdb e-kbQ9UQC9   
Human Protein Atlas [tissue]ENSG00000137975-CLCA2 [tissue]
HPRD04923
Protein Interaction databases
DIP (DOE-UCLA)Q9UQC9
IntAct (EBI)Q9UQC9
BioGRIDCLCA2
STRING (EMBL)CLCA2
ZODIACCLCA2
Ontologies - Pathways
QuickGOQ9UQC9
Ontology : AmiGOintracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  nucleoplasm  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  chloride transport  cell adhesion  metallopeptidase activity  basal plasma membrane  ligand-gated ion channel activity  cell junction  nuclear membrane  ion transmembrane transport  metal ion binding  
Ontology : EGO-EBIintracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  nucleoplasm  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  chloride transport  cell adhesion  metallopeptidase activity  basal plasma membrane  ligand-gated ion channel activity  cell junction  nuclear membrane  ion transmembrane transport  metal ion binding  
Pathways : KEGGOlfactory transduction    Pancreatic secretion   
NDEx NetworkCLCA2
Atlas of Cancer Signalling NetworkCLCA2
Wikipedia pathwaysCLCA2
Orthology - Evolution
OrthoDB9635
GeneTree (enSembl)ENSG00000137975
Phylogenetic Trees/Animal Genes : TreeFamCLCA2
Homologs : HomoloGeneCLCA2
Homology/Alignments : Family Browser (UCSC)CLCA2
Gene fusions - Rearrangements
Fusion : MitelmanRUNX1/CLCA2 [21q22.12/1p22.3]  
Fusion : QuiverCLCA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCA2
dbVarCLCA2
ClinVarCLCA2
MonarchCLCA2
1000_GenomesCLCA2 
Exome Variant ServerCLCA2
GNOMAD BrowserENSG00000137975
Varsome BrowserCLCA2
ACMGCLCA2 variants
VarityQ9UQC9
Genomic Variants (DGV)CLCA2 [DGVbeta]
DECIPHERCLCA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCA2 
Mutations
ICGC Data PortalCLCA2 
TCGA Data PortalCLCA2 
Broad Tumor PortalCLCA2
OASIS PortalCLCA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLCA2
Mutations and Diseases : HGMDCLCA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLCA2
DgiDB (Drug Gene Interaction Database)CLCA2
DoCM (Curated mutations)CLCA2
CIViC (Clinical Interpretations of Variants in Cancer)CLCA2
Cancer3DCLCA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604003   
Orphanet
DisGeNETCLCA2
MedgenCLCA2
Genetic Testing Registry CLCA2
NextProtQ9UQC9 [Medical]
GENETestsCLCA2
Target ValidationCLCA2
Huge Navigator CLCA2 [HugePedia]
ClinGenCLCA2
Clinical trials, drugs, therapy
MyCancerGenomeCLCA2
Protein Interactions : CTDCLCA2
Pharm GKB GenePA26543
PharosQ9UQC9
Clinical trialCLCA2
Miscellaneous
canSAR (ICR)CLCA2
HarmonizomeCLCA2
DataMed IndexCLCA2
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLCA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:04:11 CEST 2021

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