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CLCA2 (chloride channel accessory 2)

Identity

Alias_nameschloride channel, calcium activated, family member 2
chloride channel regulator 2
Alias_symbol (synonym)CLCRG2
Other aliasCACC
CACC3
CaCC-3
HGNC (Hugo) CLCA2
LocusID (NCBI) 9635
Atlas_Id 40096
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86423883 and ends at 86456557 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RUNX1 (21q22.12) / CLCA2 (1p22.3)SVBP (1p34.2) / CLCA2 (1p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;21)(p22;q22) RUNX1/CLCA2


External links

Nomenclature
HGNC (Hugo)CLCA2   2016
Cards
Entrez_Gene (NCBI)CLCA2  9635  chloride channel accessory 2
AliasesCACC; CACC3; CLCRG2; CaCC-3
GeneCards (Weizmann)CLCA2
Ensembl hg19 (Hinxton)ENSG00000137975 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137975 [Gene_View]  chr1:86423883-86456557 [Contig_View]  CLCA2 [Vega]
ICGC DataPortalENSG00000137975
TCGA cBioPortalCLCA2
AceView (NCBI)CLCA2
Genatlas (Paris)CLCA2
WikiGenes9635
SOURCE (Princeton)CLCA2
Genetics Home Reference (NIH)CLCA2
Genomic and cartography
GoldenPath hg38 (UCSC)CLCA2  -     chr1:86423883-86456557 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCA2  -     1p22.3   [Description]    (hg19-Feb_2009)
EnsemblCLCA2 - 1p22.3 [CytoView hg19]  CLCA2 - 1p22.3 [CytoView hg38]
Mapping of homologs : NCBICLCA2 [Mapview hg19]  CLCA2 [Mapview hg38]
OMIM604003   
Gene and transcription
Genbank (Entrez)AB026833 AF043977 AF127980 AK290348 AK296719
RefSeq transcript (Entrez)NM_006536
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLCA2
Cluster EST : UnigeneHs.241551 [ NCBI ]
CGAP (NCI)Hs.241551
Alternative Splicing GalleryENSG00000137975
Gene ExpressionCLCA2 [ NCBI-GEO ]   CLCA2 [ EBI - ARRAY_EXPRESS ]   CLCA2 [ SEEK ]   CLCA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9635
GTEX Portal (Tissue expression)CLCA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQC9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQC9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQC9
Splice isoforms : SwissVarQ9UQC9
PhosPhoSitePlusQ9UQC9
Domaine pattern : Prosite (Expaxy)VWFA (PS50234)   
Domains : Interpro (EBI)CLCA    CLCA_chordata    VWF_A   
Domain families : Pfam (Sanger)CLCA (PF08434)   
Domain families : Pfam (NCBI)pfam08434   
Domain families : Smart (EMBL)VWA (SM00327)  
Conserved Domain (NCBI)CLCA2
DMDM Disease mutations9635
Blocks (Seattle)CLCA2
SuperfamilyQ9UQC9
Human Protein AtlasENSG00000137975
Peptide AtlasQ9UQC9
HPRD04923
IPIIPI00299094   IPI00909254   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQC9
IntAct (EBI)Q9UQC9
FunCoupENSG00000137975
BioGRIDCLCA2
STRING (EMBL)CLCA2
ZODIACCLCA2
Ontologies - Pathways
QuickGOQ9UQC9
Ontology : AmiGOmetalloendopeptidase activity  intracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  nucleus  plasma membrane  integral component of plasma membrane  proteolysis  transport  cell adhesion  basal plasma membrane  ligand-gated ion channel activity  cell junction  ion transmembrane transport  metal ion binding  chloride transmembrane transport  
Ontology : EGO-EBImetalloendopeptidase activity  intracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  nucleus  plasma membrane  integral component of plasma membrane  proteolysis  transport  cell adhesion  basal plasma membrane  ligand-gated ion channel activity  cell junction  ion transmembrane transport  metal ion binding  chloride transmembrane transport  
Pathways : KEGGOlfactory transduction    Pancreatic secretion   
NDEx NetworkCLCA2
Atlas of Cancer Signalling NetworkCLCA2
Wikipedia pathwaysCLCA2
Orthology - Evolution
OrthoDB9635
GeneTree (enSembl)ENSG00000137975
Phylogenetic Trees/Animal Genes : TreeFamCLCA2
HOVERGENQ9UQC9
HOGENOMQ9UQC9
Homologs : HomoloGeneCLCA2
Homology/Alignments : Family Browser (UCSC)CLCA2
Gene fusions - Rearrangements
Fusion : MitelmanRUNX1/CLCA2 [21q22.12/1p22.3]  [t(1;21)(p22;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCA2
dbVarCLCA2
ClinVarCLCA2
1000_GenomesCLCA2 
Exome Variant ServerCLCA2
ExAC (Exome Aggregation Consortium)CLCA2 (select the gene name)
Genetic variants : HAPMAP9635
Genomic Variants (DGV)CLCA2 [DGVbeta]
DECIPHERCLCA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCA2 
Mutations
ICGC Data PortalCLCA2 
TCGA Data PortalCLCA2 
Broad Tumor PortalCLCA2
OASIS PortalCLCA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLCA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLCA2
DgiDB (Drug Gene Interaction Database)CLCA2
DoCM (Curated mutations)CLCA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLCA2 (select a term)
intoGenCLCA2
Cancer3DCLCA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604003   
Orphanet
MedgenCLCA2
Genetic Testing Registry CLCA2
NextProtQ9UQC9 [Medical]
TSGene9635
GENETestsCLCA2
Target ValidationCLCA2
Huge Navigator CLCA2 [HugePedia]
snp3D : Map Gene to Disease9635
BioCentury BCIQCLCA2
ClinGenCLCA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9635
Chemical/Pharm GKB GenePA26543
Clinical trialCLCA2
Miscellaneous
canSAR (ICR)CLCA2 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLCA2
EVEXCLCA2
GoPubMedCLCA2
iHOPCLCA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:49:59 CEST 2017

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