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CLCA4 (chloride channel accessory 4)

Identity

Alias_nameschloride channel, calcium activated, family member 4
chloride channel regulator 4
Alias_symbol (synonym)CaCC2
Other aliasCaCC
HGNC (Hugo) CLCA4
LocusID (NCBI) 22802
Atlas_Id 61850
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86547076 and ends at 86580749 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLCA4   2018
Cards
Entrez_Gene (NCBI)CLCA4  22802  chloride channel accessory 4
AliasesCaCC; CaCC2
GeneCards (Weizmann)CLCA4
Ensembl hg19 (Hinxton)ENSG00000016602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000016602 [Gene_View]  chr1:86547076-86580749 [Contig_View]  CLCA4 [Vega]
ICGC DataPortalENSG00000016602
TCGA cBioPortalCLCA4
AceView (NCBI)CLCA4
Genatlas (Paris)CLCA4
WikiGenes22802
SOURCE (Princeton)CLCA4
Genetics Home Reference (NIH)CLCA4
Genomic and cartography
GoldenPath hg38 (UCSC)CLCA4  -     chr1:86547076-86580749 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCA4  -     1p22.3   [Description]    (hg19-Feb_2009)
EnsemblCLCA4 - 1p22.3 [CytoView hg19]  CLCA4 - 1p22.3 [CytoView hg38]
Mapping of homologs : NCBICLCA4 [Mapview hg19]  CLCA4 [Mapview hg38]
OMIM616857   
Gene and transcription
Genbank (Entrez)AF127035 AK000072 AK000138 AK293766 AK307785
RefSeq transcript (Entrez)NM_012128
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLCA4
Cluster EST : UnigeneHs.567422 [ NCBI ]
CGAP (NCI)Hs.567422
Alternative Splicing GalleryENSG00000016602
Gene ExpressionCLCA4 [ NCBI-GEO ]   CLCA4 [ EBI - ARRAY_EXPRESS ]   CLCA4 [ SEEK ]   CLCA4 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22802
GTEX Portal (Tissue expression)CLCA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14CN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14CN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14CN2
Splice isoforms : SwissVarQ14CN2
PhosPhoSitePlusQ14CN2
Domaine pattern : Prosite (Expaxy)VWFA (PS50234)   
Domains : Interpro (EBI)CLCA    CLCA_chordata    VWF_A   
Domain families : Pfam (Sanger)CLCA (PF08434)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam08434    pfam00092   
Domain families : Smart (EMBL)VWA (SM00327)  
Conserved Domain (NCBI)CLCA4
DMDM Disease mutations22802
Blocks (Seattle)CLCA4
SuperfamilyQ14CN2
Human Protein AtlasENSG00000016602
Peptide AtlasQ14CN2
HPRD16719
IPIIPI01018986   IPI00298082   
Protein Interaction databases
DIP (DOE-UCLA)Q14CN2
IntAct (EBI)Q14CN2
FunCoupENSG00000016602
BioGRIDCLCA4
STRING (EMBL)CLCA4
ZODIACCLCA4
Ontologies - Pathways
QuickGOQ14CN2
Ontology : AmiGOmetalloendopeptidase activity  intracellular calcium activated chloride channel activity  chloride channel activity  plasma membrane  integral component of plasma membrane  proteolysis  transport  apical plasma membrane  ion transmembrane transport  metal ion binding  extracellular exosome  chloride transmembrane transport  
Ontology : EGO-EBImetalloendopeptidase activity  intracellular calcium activated chloride channel activity  chloride channel activity  plasma membrane  integral component of plasma membrane  proteolysis  transport  apical plasma membrane  ion transmembrane transport  metal ion binding  extracellular exosome  chloride transmembrane transport  
Pathways : KEGGOlfactory transduction    Pancreatic secretion   
NDEx NetworkCLCA4
Atlas of Cancer Signalling NetworkCLCA4
Wikipedia pathwaysCLCA4
Orthology - Evolution
OrthoDB22802
GeneTree (enSembl)ENSG00000016602
Phylogenetic Trees/Animal Genes : TreeFamCLCA4
HOVERGENQ14CN2
HOGENOMQ14CN2
Homologs : HomoloGeneCLCA4
Homology/Alignments : Family Browser (UCSC)CLCA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCA4
dbVarCLCA4
ClinVarCLCA4
1000_GenomesCLCA4 
Exome Variant ServerCLCA4
ExAC (Exome Aggregation Consortium)CLCA4 (select the gene name)
Genetic variants : HAPMAP22802
Genomic Variants (DGV)CLCA4 [DGVbeta]
DECIPHERCLCA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCA4 
Mutations
ICGC Data PortalCLCA4 
TCGA Data PortalCLCA4 
Broad Tumor PortalCLCA4
OASIS PortalCLCA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLCA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLCA4
DgiDB (Drug Gene Interaction Database)CLCA4
DoCM (Curated mutations)CLCA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLCA4 (select a term)
intoGenCLCA4
Cancer3DCLCA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616857   
Orphanet49   
MedgenCLCA4
Genetic Testing Registry CLCA4
NextProtQ14CN2 [Medical]
TSGene22802
GENETestsCLCA4
Huge Navigator CLCA4 [HugePedia]
snp3D : Map Gene to Disease22802
BioCentury BCIQCLCA4
ClinGenCLCA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22802
Chemical/Pharm GKB GenePA26545
Clinical trialCLCA4
Miscellaneous
canSAR (ICR)CLCA4 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLCA4
EVEXCLCA4
GoPubMedCLCA4
iHOPCLCA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:06:02 CEST 2017

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