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CLCA4 (chloride channel accessory 4)

Identity

Alias (NCBI)CaCC
CaCC2
HGNC (Hugo) CLCA4
HGNC Alias symbCaCC2
HGNC Previous namechloride channel, calcium activated, family member 4
 chloride channel regulator 4
LocusID (NCBI) 22802
Atlas_Id 58262
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86547078 and ends at 86580749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLCA4   2018
Cards
Entrez_Gene (NCBI)CLCA4    chloride channel accessory 4
AliasesCaCC; CaCC2
GeneCards (Weizmann)CLCA4
Ensembl hg19 (Hinxton)ENSG00000016602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000016602 [Gene_View]  ENSG00000016602 [Sequence]  chr1:86547078-86580749 [Contig_View]  CLCA4 [Vega]
ICGC DataPortalENSG00000016602
TCGA cBioPortalCLCA4
AceView (NCBI)CLCA4
Genatlas (Paris)CLCA4
SOURCE (Princeton)CLCA4
Genetics Home Reference (NIH)CLCA4
Genomic and cartography
GoldenPath hg38 (UCSC)CLCA4  -     chr1:86547078-86580749 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCA4  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathCLCA4 - 1p22.3 [CytoView hg19]  CLCA4 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000016602
Genome Data Viewer NCBICLCA4 [Mapview hg19]  
OMIM616857   
Gene and transcription
Genbank (Entrez)AF127035 AK000072 AK000138 AK293766 AK307785
RefSeq transcript (Entrez)NM_012128
Consensus coding sequences : CCDS (NCBI)CLCA4
Gene ExpressionCLCA4 [ NCBI-GEO ]   CLCA4 [ EBI - ARRAY_EXPRESS ]   CLCA4 [ SEEK ]   CLCA4 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCA4 [ Firebrowse - Broad ]
GenevisibleExpression of CLCA4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22802
GTEX Portal (Tissue expression)CLCA4
Human Protein AtlasENSG00000016602-CLCA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14CN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14CN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14CN2
PhosPhoSitePlusQ14CN2
Domaine pattern : Prosite (Expaxy)VWFA (PS50234)   
Domains : Interpro (EBI)CLCA_chordata    CLCA_N    VWF_A    vWFA_dom_sf   
Domain families : Pfam (Sanger)CLCA (PF08434)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam08434    pfam00092   
Domain families : Smart (EMBL)VWA (SM00327)  
Conserved Domain (NCBI)CLCA4
SuperfamilyQ14CN2
AlphaFold pdb e-kbQ14CN2   
Human Protein Atlas [tissue]ENSG00000016602-CLCA4 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q14CN2
IntAct (EBI)Q14CN2
BioGRIDCLCA4
STRING (EMBL)CLCA4
ZODIACCLCA4
Ontologies - Pathways
QuickGOQ14CN2
Ontology : AmiGOintracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  plasma membrane  integral component of plasma membrane  proteolysis  chloride transport  metallopeptidase activity  apical plasma membrane  ion transmembrane transport  metal ion binding  
Ontology : EGO-EBIintracellular calcium activated chloride channel activity  chloride channel activity  extracellular region  plasma membrane  integral component of plasma membrane  proteolysis  chloride transport  metallopeptidase activity  apical plasma membrane  ion transmembrane transport  metal ion binding  
Pathways : KEGGOlfactory transduction    Pancreatic secretion   
NDEx NetworkCLCA4
Atlas of Cancer Signalling NetworkCLCA4
Wikipedia pathwaysCLCA4
Orthology - Evolution
OrthoDB22802
GeneTree (enSembl)ENSG00000016602
Phylogenetic Trees/Animal Genes : TreeFamCLCA4
Homologs : HomoloGeneCLCA4
Homology/Alignments : Family Browser (UCSC)CLCA4
Gene fusions - Rearrangements
Fusion : QuiverCLCA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCA4
dbVarCLCA4
ClinVarCLCA4
MonarchCLCA4
1000_GenomesCLCA4 
Exome Variant ServerCLCA4
GNOMAD BrowserENSG00000016602
Varsome BrowserCLCA4
ACMGCLCA4 variants
VarityQ14CN2
Genomic Variants (DGV)CLCA4 [DGVbeta]
DECIPHERCLCA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCA4 
Mutations
ICGC Data PortalCLCA4 
TCGA Data PortalCLCA4 
Broad Tumor PortalCLCA4
OASIS PortalCLCA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCA4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLCA4
Mutations and Diseases : HGMDCLCA4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLCA4
DgiDB (Drug Gene Interaction Database)CLCA4
DoCM (Curated mutations)CLCA4
CIViC (Clinical Interpretations of Variants in Cancer)CLCA4
Cancer3DCLCA4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616857   
Orphanet
DisGeNETCLCA4
MedgenCLCA4
Genetic Testing Registry CLCA4
NextProtQ14CN2 [Medical]
GENETestsCLCA4
Target ValidationCLCA4
Huge Navigator CLCA4 [HugePedia]
ClinGenCLCA4
Clinical trials, drugs, therapy
MyCancerGenomeCLCA4
Protein Interactions : CTDCLCA4
PharosQ14CN2
Clinical trialCLCA4
Miscellaneous
canSAR (ICR)CLCA4
HarmonizomeCLCA4
DataMed IndexCLCA4
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLCA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:04:11 CEST 2021

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