CLCF1 (cardiotrophin like cytokine factor 1)

2003-12-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
BSF-3,BSF3,CISS2,CLC,NNT-1,NNT1,NR6

Other Information

Locus ID:

NCBI: 23529
MIM: 607672
HGNC: 17412
Ensembl: ENSG00000175505

Variants:

dbSNP: 23529
ClinVar: 23529
TCGA: ENSG00000175505
COSMIC: CLCF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175505ENST00000312438Q9UBD9
ENSG00000175505ENST00000533438Q9UBD9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258436712015Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.19
167828202006Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.17
268583032016Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover.11
187280122008Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.9
126399012003Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3.8
261987692015Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.5
295073442018Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity.3
317001752019Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.1

Citation

Dessen P

CLCF1 (cardiotrophin like cytokine factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40095/clcf1