CLCN3 (chloride voltage-gated channel 3)

2011-04-01  

Identity

HGNC
CLCN3
LOCATION
4q33
LOCUSID
1182
ALIAS
CLC3,ClC-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1182
MIM: 600580
HGNC: 2021
Ensembl: ENSG00000109572

Variants:

dbSNP: 1182
ClinVar: 1182
TCGA: ENSG00000109572
COSMIC: CLCN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109572ENST00000347613P51790
ENSG00000109572ENST00000360642P51790
ENSG00000109572ENST00000504131A0A0A0MTB7
ENSG00000109572ENST00000507875E9PE15
ENSG00000109572ENST00000511092D6RDZ6
ENSG00000109572ENST00000512813D6RIX3
ENSG00000109572ENST00000513761P51790
ENSG00000109572ENST00000515420H0Y8Z8
ENSG00000109572ENST00000613795A0A087WU31

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362610972022ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy.1
362610972022ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy.1
333835612021Swelling-activated ClC-3 activity regulates prostaglandin E(2) release in human OUMS-27 chondrocytes.4
341860282021Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.13
333835612021Swelling-activated ClC-3 activity regulates prostaglandin E(2) release in human OUMS-27 chondrocytes.4
341860282021Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders.13
327722292020ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy.4
330693592020Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/β-catenin signaling pathway.11
330934582020ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma.9
327722292020ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy.4
330693592020Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/β-catenin signaling pathway.11
330934582020ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma.9
302305442019Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression.15
306788062019Chloride channel 3 (CIC-3) predicts the tumor size in hepatocarcinoma.2
309054322019Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma.6

Citation

Dessen P

CLCN3 (chloride voltage-gated channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52160/clcn3