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CLCN6 (chloride voltage-gated channel 6)

Identity

Alias_nameschloride channel 6
chloride channel, voltage-sensitive 6
Alias_symbol (synonym)CLC-6
KIAA0046
ClC-6
Other alias
HGNC (Hugo) CLCN6
LocusID (NCBI) 1185
Atlas_Id 40097
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11806096 and ends at 11843144 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLCN6 (1p36.22) / BRAF (7q34)CLCN6 (1p36.22) / CLCN6 (1p36.22)CLCN6 (1p36.22) / RAF1 (3p25.2)
KIAA0100 (17q11.2) / CLCN6 (1p36.22)CLCN6 1p36.22 / BRAF 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLCN6   2024
Cards
Entrez_Gene (NCBI)CLCN6  1185  chloride voltage-gated channel 6
AliasesCLC-6
GeneCards (Weizmann)CLCN6
Ensembl hg19 (Hinxton)ENSG00000011021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011021 [Gene_View]  chr1:11806096-11843144 [Contig_View]  CLCN6 [Vega]
ICGC DataPortalENSG00000011021
TCGA cBioPortalCLCN6
AceView (NCBI)CLCN6
Genatlas (Paris)CLCN6
WikiGenes1185
SOURCE (Princeton)CLCN6
Genetics Home Reference (NIH)CLCN6
Genomic and cartography
GoldenPath hg38 (UCSC)CLCN6  -     chr1:11806096-11843144 +  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLCN6  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblCLCN6 - 1p36.22 [CytoView hg19]  CLCN6 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBICLCN6 [Mapview hg19]  CLCN6 [Mapview hg38]
OMIM602726   
Gene and transcription
Genbank (Entrez)AK289999 AK294764 AK307098 BC050457 BC117420
RefSeq transcript (Entrez)NM_001256959 NM_001286 NM_021735 NM_021736 NM_021737
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLCN6
Cluster EST : UnigeneHs.193043 [ NCBI ]
CGAP (NCI)Hs.193043
Alternative Splicing GalleryENSG00000011021
Gene ExpressionCLCN6 [ NCBI-GEO ]   CLCN6 [ EBI - ARRAY_EXPRESS ]   CLCN6 [ SEEK ]   CLCN6 [ MEM ]
Gene Expression Viewer (FireBrowse)CLCN6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1185
GTEX Portal (Tissue expression)CLCN6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51797   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51797  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51797
Splice isoforms : SwissVarP51797
PhosPhoSitePlusP51797
Domaine pattern : Prosite (Expaxy)CBS (PS51371)   
Domains : Interpro (EBI)CBS_dom    Cl-channel_core    Cl-channel_volt-gated    Cl_channel-6   
Domain families : Pfam (Sanger)CBS (PF00571)    Voltage_CLC (PF00654)   
Domain families : Pfam (NCBI)pfam00571    pfam00654   
Domain families : Smart (EMBL)CBS (SM00116)  
Conserved Domain (NCBI)CLCN6
DMDM Disease mutations1185
Blocks (Seattle)CLCN6
SuperfamilyP51797
Human Protein AtlasENSG00000011021
Peptide AtlasP51797
HPRD04102
IPIIPI00180121   IPI00305252   IPI00395741   IPI00414669   IPI00642888   IPI01012707   IPI00639914   
Protein Interaction databases
DIP (DOE-UCLA)P51797
IntAct (EBI)P51797
FunCoupENSG00000011021
BioGRIDCLCN6
STRING (EMBL)CLCN6
ZODIACCLCN6
Ontologies - Pathways
QuickGOP51797
Ontology : AmiGOvoltage-gated chloride channel activity  voltage-gated chloride channel activity  ATP binding  lysosomal membrane  chloride transport  cell volume homeostasis  signal transduction  response to mechanical stimulus  endosome membrane  antiporter activity  integral component of membrane  ion transmembrane transport  chloride transmembrane transport  regulation of anion transmembrane transport  
Ontology : EGO-EBIvoltage-gated chloride channel activity  voltage-gated chloride channel activity  ATP binding  lysosomal membrane  chloride transport  cell volume homeostasis  signal transduction  response to mechanical stimulus  endosome membrane  antiporter activity  integral component of membrane  ion transmembrane transport  chloride transmembrane transport  regulation of anion transmembrane transport  
NDEx NetworkCLCN6
Atlas of Cancer Signalling NetworkCLCN6
Wikipedia pathwaysCLCN6
Orthology - Evolution
OrthoDB1185
GeneTree (enSembl)ENSG00000011021
Phylogenetic Trees/Animal Genes : TreeFamCLCN6
HOVERGENP51797
HOGENOMP51797
Homologs : HomoloGeneCLCN6
Homology/Alignments : Family Browser (UCSC)CLCN6
Gene fusions - Rearrangements
Fusion : MitelmanCLCN6/BRAF [1p36.22/7q34]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLCN6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLCN6
dbVarCLCN6
ClinVarCLCN6
1000_GenomesCLCN6 
Exome Variant ServerCLCN6
ExAC (Exome Aggregation Consortium)CLCN6 (select the gene name)
Genetic variants : HAPMAP1185
Genomic Variants (DGV)CLCN6 [DGVbeta]
DECIPHERCLCN6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLCN6 
Mutations
ICGC Data PortalCLCN6 
TCGA Data PortalCLCN6 
Broad Tumor PortalCLCN6
OASIS PortalCLCN6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLCN6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLCN6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLCN6
DgiDB (Drug Gene Interaction Database)CLCN6
DoCM (Curated mutations)CLCN6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLCN6 (select a term)
intoGenCLCN6
Cancer3DCLCN6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602726   
Orphanet
MedgenCLCN6
Genetic Testing Registry CLCN6
NextProtP51797 [Medical]
TSGene1185
GENETestsCLCN6
Target ValidationCLCN6
Huge Navigator CLCN6 [HugePedia]
snp3D : Map Gene to Disease1185
BioCentury BCIQCLCN6
ClinGenCLCN6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1185
Chemical/Pharm GKB GenePA26551
Clinical trialCLCN6
Miscellaneous
canSAR (ICR)CLCN6 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLCN6
EVEXCLCN6
GoPubMedCLCN6
iHOPCLCN6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:02:39 CEST 2017

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