| Note | Claudin 10 plays a major role as a component of tight junctions. CLDN10 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. They are also critical in maintaining cell polarity and mediating signals. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcripts encoding different isoforms of CLDN10 have been reported, but not all of them have been recorded. |
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| | The four transmembrane, two extracellular, 3 helical and two cytoplasmic domains of claudin protein. |
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| Description | 228 amino acids. Modified amino acid residue at position 94 is a phosphoserine. Human and mouse isoforms of CLDN10 have been cloned. Claudin-10 shares between 20 and 45% sequence similarity between other claudin family members at the amino acid level, displaying highest sequence similarity to claudin-15.
CLAUDIN10 is a 4-element fingerprint that provides a signature for claudin-10 proteins. The fingerprint was derived from an initial alignment of 2 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length, focusing on those sections thatcharacterize claudin-10 and distinguish it from other family members - motif 1 lies in the first TM domain; motif 2 resides within in the second TM domain; motifs 3 spans part of the fourth TM domain and part of the C-terminal region; and motif 4 resides within the cytoplasmic C-terminus. |
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| | Sequence similarity between the various claudins showing that claudin 10 has the highest sequence similarity to claudin 15. |
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| Expression | At the cell membrane in 85 organs and 13 developmental stages (Bgee)[P78369]. |
| Localisation | Cell membrane. |
| Function | From the KEGG pathway.
Claudin 10 as an integral part of tight junction composition plays an important role in Leukocyte migration. They are also important components of cell adhesion molecules and serve as a receptor for the HCV virus via their extracellular loop.
hsa04514: Cell adhesion molecules (CAMs)
hsa04530: Tight junction
hsa04670: Leukocyte transendothelial migration
hsa05160: Hepatitis C |
| Homology | The CLDN10 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish. |
| Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. |
| Cheung ST, Leung KL, Ip YC, Chen X, Fong DY, Ng IO, Fan ST, So S. |
| Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):551-6. |
| PMID 15701840 |
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| Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. |
| Gunzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Muller D. |
| J Cell Sci. 2009 May 15;122(Pt 10):1507-17. Epub 2009 Apr 21. |
| PMID 19383724 |
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| Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival. |
| Huang GW, Ding X, Chen SL, Zeng L. |
| J Cancer Res Clin Oncol. 2011 Aug;137(8):1213-8. Epub 2011 Jun 7. |
| PMID 21647678 |
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| The claudins. |
| Lal-Nag M, Morin PJ. |
| Genome Biol. 2009;10(8):235. Epub 2009 Aug 26. (REVIEW) |
| PMID 19706201 |
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| Claudin 10 is a glandular epithelial marker in the chicken model as human epithelial ovarian cancer. |
| Seo HW, Rengaraj D, Choi JW, Ahn SE, Song YS, Song G, Han JY. |
| Int J Gynecol Cancer. 2010 Dec;20(9):1465-73. |
| PMID 21370593 |
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