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CLDN12 (claudin 12)

Identity

Alias (NCBI)-
HGNC (Hugo) CLDN12
LocusID (NCBI) 9069
Atlas_Id 49800
Location 7q21.13  [Link to chromosome band 7q21]
Location_base_pair Starts at 90403461 and ends at 90415954 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLDN12 (7q21.13) / SPCS3 (4q34.2)CLDN12 7q21.13 / SPCS3 4q34.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLDN12   2034
Cards
Entrez_Gene (NCBI)CLDN12    claudin 12
Aliases
GeneCards (Weizmann)CLDN12
Ensembl hg19 (Hinxton)ENSG00000157224 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157224 [Gene_View]  ENSG00000157224 [Sequence]  chr7:90403461-90415954 [Contig_View]  CLDN12 [Vega]
ICGC DataPortalENSG00000157224
TCGA cBioPortalCLDN12
AceView (NCBI)CLDN12
Genatlas (Paris)CLDN12
SOURCE (Princeton)CLDN12
Genetics Home Reference (NIH)CLDN12
Genomic and cartography
GoldenPath hg38 (UCSC)CLDN12  -     chr7:90403461-90415954 +  7q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLDN12  -     7q21.13   [Description]    (hg19-Feb_2009)
GoldenPathCLDN12 - 7q21.13 [CytoView hg19]  CLDN12 - 7q21.13 [CytoView hg38]
ImmunoBaseENSG00000157224
Genome Data Viewer NCBICLDN12 [Mapview hg19]  
OMIM611232   
Gene and transcription
Genbank (Entrez)AK312480 AL136770 BC036754 BC068532 CR533470
RefSeq transcript (Entrez)NM_001185072 NM_001185073 NM_012129
Consensus coding sequences : CCDS (NCBI)CLDN12
Gene ExpressionCLDN12 [ NCBI-GEO ]   CLDN12 [ EBI - ARRAY_EXPRESS ]   CLDN12 [ SEEK ]   CLDN12 [ MEM ]
Gene Expression Viewer (FireBrowse)CLDN12 [ Firebrowse - Broad ]
GenevisibleExpression of CLDN12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9069
GTEX Portal (Tissue expression)CLDN12
Human Protein AtlasENSG00000157224-CLDN12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56749
PhosPhoSitePlusP56749
Domaine pattern : Prosite (Expaxy)CLAUDIN (PS01346)   
Domains : Interpro (EBI)Claudin12    Claudin_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CLDN12
SuperfamilyP56749
AlphaFold pdb e-kbP56749   
Human Protein Atlas [tissue]ENSG00000157224-CLDN12 [tissue]
HPRD13064
Protein Interaction databases
DIP (DOE-UCLA)P56749
IntAct (EBI)P56749
BioGRIDCLDN12
STRING (EMBL)CLDN12
ZODIACCLDN12
Ontologies - Pathways
QuickGOP56749
Ontology : AmiGOprotein binding  plasma membrane  plasma membrane  bicellular tight junction  integral component of membrane  lateral plasma membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  maintenance of blood-brain barrier  identical protein binding  tight junction assembly  
Ontology : EGO-EBIprotein binding  plasma membrane  plasma membrane  bicellular tight junction  integral component of membrane  lateral plasma membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  maintenance of blood-brain barrier  identical protein binding  tight junction assembly  
NDEx NetworkCLDN12
Atlas of Cancer Signalling NetworkCLDN12
Wikipedia pathwaysCLDN12
Orthology - Evolution
OrthoDB9069
GeneTree (enSembl)ENSG00000157224
Phylogenetic Trees/Animal Genes : TreeFamCLDN12
Homologs : HomoloGeneCLDN12
Homology/Alignments : Family Browser (UCSC)CLDN12
Gene fusions - Rearrangements
Fusion : MitelmanCLDN12/SPCS3 [7q21.13/4q34.2]  
Fusion : QuiverCLDN12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLDN12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLDN12
dbVarCLDN12
ClinVarCLDN12
MonarchCLDN12
1000_GenomesCLDN12 
Exome Variant ServerCLDN12
GNOMAD BrowserENSG00000157224
Varsome BrowserCLDN12
ACMGCLDN12 variants
VarityP56749
Genomic Variants (DGV)CLDN12 [DGVbeta]
DECIPHERCLDN12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLDN12 
Mutations
ICGC Data PortalCLDN12 
TCGA Data PortalCLDN12 
Broad Tumor PortalCLDN12
OASIS PortalCLDN12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLDN12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLDN12
Mutations and Diseases : HGMDCLDN12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLDN12
DgiDB (Drug Gene Interaction Database)CLDN12
DoCM (Curated mutations)CLDN12
CIViC (Clinical Interpretations of Variants in Cancer)CLDN12
Cancer3DCLDN12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611232   
Orphanet
DisGeNETCLDN12
MedgenCLDN12
Genetic Testing Registry CLDN12
NextProtP56749 [Medical]
GENETestsCLDN12
Target ValidationCLDN12
Huge Navigator CLDN12 [HugePedia]
ClinGenCLDN12
Clinical trials, drugs, therapy
MyCancerGenomeCLDN12
Protein Interactions : CTDCLDN12
Pharm GKB GenePA26560
PharosP56749
Clinical trialCLDN12
Miscellaneous
canSAR (ICR)CLDN12
HarmonizomeCLDN12
DataMed IndexCLDN12
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLDN12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:04:13 CEST 2021

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