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CLDN18 (claudin 18)

Identity

Alias_namesSFTPJ
surfactant associated protein J
Other aliasSFTA5
HGNC (Hugo) CLDN18
LocusID (NCBI) 51208
Atlas_Id 49740
Location 3q22.3  [Link to chromosome band 3q22]
Location_base_pair Starts at 138010164 and ends at 138033652 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARMC8 (3q22.3) / CLDN18 (3q22.3)CLDN18 (3q22.3) / ARHGAP26 (5q31.3)CLDN18 (3q22.3) / ARHGAP6 (Xp22.2)
CLDN18 (3q22.3) / UACA (15q23)PLS1 (3q23) / CLDN18 (3q22.3)ARMC8 3q22.3 / CLDN18 3q22.3
PLS1 3q23 / CLDN18 3q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(3;3)(q22;q22) ARMC8/CLDN18
t(3;3)(q22;q23) PLS1/CLDN18
t(3;5)(q22;q31) CLDN18/ARHGAP26
t(X;3)(p22;q22) CLDN18/ARHGAP6

External links

Nomenclature
HGNC (Hugo)CLDN18   2039
Cards
Entrez_Gene (NCBI)CLDN18  51208  claudin 18
AliasesSFTA5; SFTPJ
GeneCards (Weizmann)CLDN18
Ensembl hg19 (Hinxton)ENSG00000066405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066405 [Gene_View]  chr3:138010164-138033652 [Contig_View]  CLDN18 [Vega]
ICGC DataPortalENSG00000066405
TCGA cBioPortalCLDN18
AceView (NCBI)CLDN18
Genatlas (Paris)CLDN18
WikiGenes51208
SOURCE (Princeton)CLDN18
Genetics Home Reference (NIH)CLDN18
Genomic and cartography
GoldenPath hg38 (UCSC)CLDN18  -     chr3:138010164-138033652 +  3q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLDN18  -     3q22.3   [Description]    (hg19-Feb_2009)
EnsemblCLDN18 - 3q22.3 [CytoView hg19]  CLDN18 - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBICLDN18 [Mapview hg19]  CLDN18 [Mapview hg38]
OMIM609210   
Gene and transcription
Genbank (Entrez)AF221069 AF349452 AK098474 AK298103 AY102073
RefSeq transcript (Entrez)NM_001002026 NM_016369
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLDN18
Cluster EST : UnigeneHs.655324 [ NCBI ]
CGAP (NCI)Hs.655324
Alternative Splicing GalleryENSG00000066405
Gene ExpressionCLDN18 [ NCBI-GEO ]   CLDN18 [ EBI - ARRAY_EXPRESS ]   CLDN18 [ SEEK ]   CLDN18 [ MEM ]
Gene Expression Viewer (FireBrowse)CLDN18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51208
GTEX Portal (Tissue expression)CLDN18
Human Protein AtlasENSG00000066405-CLDN18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56856   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56856  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56856
Splice isoforms : SwissVarP56856
PhosPhoSitePlusP56856
Domaine pattern : Prosite (Expaxy)CLAUDIN (PS01346)   
Domains : Interpro (EBI)Claudin    Claudin18    Claudin_CS    PMP22/EMP/MP20/Claudin   
Domain families : Pfam (Sanger)PMP22_Claudin (PF00822)   
Domain families : Pfam (NCBI)pfam00822   
Conserved Domain (NCBI)CLDN18
DMDM Disease mutations51208
Blocks (Seattle)CLDN18
SuperfamilyP56856
Human Protein Atlas [tissue]ENSG00000066405-CLDN18 [tissue]
Peptide AtlasP56856
HPRD13066
IPIIPI00011601   IPI00218314   IPI01011620   IPI00945600   
Protein Interaction databases
DIP (DOE-UCLA)P56856
IntAct (EBI)P56856
FunCoupENSG00000066405
BioGRIDCLDN18
STRING (EMBL)CLDN18
ZODIACCLDN18
Ontologies - Pathways
QuickGOP56856
Ontology : AmiGOstructural molecule activity  plasma membrane  bicellular tight junction  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  response to ethanol  negative regulation of bone resorption  digestive tract development  TNFSF11-mediated signaling pathway  negative regulation of protein localization to nucleus  negative regulation of osteoclast development  
Ontology : EGO-EBIstructural molecule activity  plasma membrane  bicellular tight junction  integral component of membrane  calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  identical protein binding  response to ethanol  negative regulation of bone resorption  digestive tract development  TNFSF11-mediated signaling pathway  negative regulation of protein localization to nucleus  negative regulation of osteoclast development  
Pathways : KEGGLeukocyte transendothelial migration    Tight junction    Cell adhesion molecules (CAMs)   
NDEx NetworkCLDN18
Atlas of Cancer Signalling NetworkCLDN18
Wikipedia pathwaysCLDN18
Orthology - Evolution
OrthoDB51208
GeneTree (enSembl)ENSG00000066405
Phylogenetic Trees/Animal Genes : TreeFamCLDN18
HOVERGENP56856
HOGENOMP56856
Homologs : HomoloGeneCLDN18
Homology/Alignments : Family Browser (UCSC)CLDN18
Gene fusions - Rearrangements
Fusion : MitelmanARMC8/CLDN18 [3q22.3/3q22.3]  [t(3;3)(q22;q22)]  
Fusion : MitelmanCLDN18/ARHGAP26 [3q22.3/5q31.3]  [t(3;5)(q22;q31)]  
Fusion : MitelmanCLDN18/ARHGAP6 [3q22.3/Xp22.2]  [t(X;3)(p22;q22)]  
Fusion : MitelmanPLS1/CLDN18 [3q23/3q22.3]  [t(3;3)(q22;q23)]  
Fusion: TCGA_MDACCARMC8 3q22.3 CLDN18 3q22.3 LGG
Fusion: TCGA_MDACCPLS1 3q23 CLDN18 3q22.3 BRCA
Fusion PortalARMC8 3q22.3 CLDN18 3q22.3 LGG
Fusion PortalPLS1 3q23 CLDN18 3q22.3 BRCA
Fusion : QuiverCLDN18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLDN18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLDN18
dbVarCLDN18
ClinVarCLDN18
1000_GenomesCLDN18 
Exome Variant ServerCLDN18
ExAC (Exome Aggregation Consortium)ENSG00000066405
GNOMAD BrowserENSG00000066405
Genetic variants : HAPMAP51208
Genomic Variants (DGV)CLDN18 [DGVbeta]
DECIPHERCLDN18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLDN18 
Mutations
ICGC Data PortalCLDN18 
TCGA Data PortalCLDN18 
Broad Tumor PortalCLDN18
OASIS PortalCLDN18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLDN18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLDN18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLDN18
DgiDB (Drug Gene Interaction Database)CLDN18
DoCM (Curated mutations)CLDN18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLDN18 (select a term)
intoGenCLDN18
Cancer3DCLDN18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609210   
Orphanet
DisGeNETCLDN18
MedgenCLDN18
Genetic Testing Registry CLDN18
NextProtP56856 [Medical]
TSGene51208
GENETestsCLDN18
Target ValidationCLDN18
Huge Navigator CLDN18 [HugePedia]
snp3D : Map Gene to Disease51208
BioCentury BCIQCLDN18
ClinGenCLDN18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51208
Chemical/Pharm GKB GenePA26565
Clinical trialCLDN18
Miscellaneous
canSAR (ICR)CLDN18 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLDN18
EVEXCLDN18
GoPubMedCLDN18
iHOPCLDN18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jun 18 19:14:53 CEST 2018
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