CLEC10A (C-type lectin domain containing 10A)

2003-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
CD301,CLECSF13,CLECSF14,HML,HML2,MGL

Other Information

Locus ID:

NCBI: 10462
MIM: 605999
HGNC: 16916
Ensembl: ENSG00000132514

Variants:

dbSNP: 10462
ClinVar: 10462
TCGA: ENSG00000132514
COSMIC: CLEC10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132514ENST00000254868Q8IUN9
ENSG00000132514ENST00000416562J3KR22
ENSG00000132514ENST00000571664Q8IUN9
ENSG00000132514ENST00000576549I3NI09
ENSG00000132514ENST00000576617Q8IUN9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
225319182012Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.27
237446462013MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion.27
261723022015MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.14
297554532018CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.12
239189272013Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).9
261479702015The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.7
277068072017Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis.7
232754492013Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.6
197763802009Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.4

Citation

Dessen P

CLEC10A (C-type lectin domain containing 10A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40100/clec10a