CLEC4A (C-type lectin domain family 4 member A)

2018-07-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CD367,CLECSF6,DCIR,DDB27,HDCGC13P,LLIR,hDCIR

Other Information

Locus ID:

NCBI: 50856
MIM: 605306
HGNC: 13257
Ensembl: ENSG00000284697

Variants:

dbSNP: 50856
ClinVar: 50856
TCGA: ENSG00000284697
COSMIC: CLEC4A

RNA/Proteins

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

References

Pubmed IDYearTitleCitations
182587992008Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.102
205302862010Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.90
185417252008The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.80
190289592009DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.56
176654552007Association of arthritis with a gene complex encoding C-type lectin-like receptors.36
215368572011DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.23
163602062006Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.18
242396072014DCIR interacts with ligands from both endogenous and pathogenic origin.17
228299302012A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort.13
145502692003The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.9

Citation

Dessen P

CLEC4A (C-type lectin domain family 4 member A)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57543/clec4a