CLEC4E (C-type lectin domain family 4 member E)

2014-11-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CLECSF9,MINCLE

Other Information

Locus ID:

NCBI: 26253
MIM: 609962
HGNC: 14555
Ensembl: ENSG00000166523

Variants:

dbSNP: 26253
ClinVar: 26253
TCGA: ENSG00000166523
COSMIC: CLEC4E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166523ENST00000299663Q9ULY5
ENSG00000166523ENST00000446457F8WFA1
ENSG00000166523ENST00000450725F8WFA1
ENSG00000166523ENST00000537698H0YGH9
ENSG00000166523ENST00000545274F5H5X7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
247215772014Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity.49
185091092008Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans.36
241014912013Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.36
262029822015Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.31
262968942015Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
277939972016Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.24
226410252012Mincle polarizes human monocyte and neutrophil responses to Candida albicans.23
191204812009Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies.22
212823712011Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans.22

Citation

Dessen P

CLEC4E (C-type lectin domain family 4 member E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61876/clec4e