CLEC5A (C-type lectin domain containing 5A)

2019-08-01 Affiliation

Identity

HGNC

CLEC5A

LOCATION

7q34

LOCUSID

23601

ALIAS

CLECSF5,MDL-1,MDL1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23601
MIM: 604987
HGNC: 2054
Ensembl: ENSG00000258227

Variants:

dbSNP: 23601
ClinVar: 23601
TCGA: ENSG00000258227
COSMIC: CLEC5A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000258227	ENST00000418498	F8WCL0
ENSG00000258227	ENST00000438351	C9JPR7
ENSG00000258227	ENST00000439991	C9JCE4
ENSG00000258227	ENST00000546910	Q9NY25
ENSG00000258227	ENST00000546910	A4D1U7
ENSG00000258227	ENST00000551012	Q14DL9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
Neutrophil degranulation	REACTOME	R-HSA-6798695

References

Pubmed ID	Year	Title	Citations
18496526	2008	CLEC5A is critical for dengue-virus-induced lethal disease.	157
23152543	2013	CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.	68
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
21094529	2011	CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.	16
21566123	2011	Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.	15
27832191	2016	Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.	12
27795434	2017	CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.	11
24465901	2014	A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients.	8
20057064	2010	Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.	6
27033255	2016	CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.	6

Citation

Dessen P

CLEC5A (C-type lectin domain containing 5A)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58034/clec5a